STRINGSTRING
CAV1 CAV1 CDC73 CDC73 LZTS2 LZTS2 SFRP1 SFRP1 INCA1 INCA1 NF1 NF1 DAB2IP DAB2IP PEX2 PEX2 IFI30 IFI30 MORC3 MORC3 DACH1 DACH1 MSTN MSTN C1QL4 C1QL4 NUPR1 NUPR1 TP53INP1 TP53INP1 MED31 MED31 TP53 TP53 B4GALT7 B4GALT7 MED25 MED25 TRIM32 TRIM32 KMT2A KMT2A PARP10 PARP10 FBXO4 FBXO4 PAWR PAWR A0A4W2CHZ4 A0A4W2CHZ4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
CDC73Cell division cycle 73. (531 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (233 aa)
NF1Neurofibromin 1. (3024 aa)
DAB2IPDAB2 interacting protein. (1267 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
IFI30IFI30 lysosomal thiol reductase. (244 aa)
MORC3MORC family CW-type zinc finger 3. (940 aa)
DACH1Dachshund family transcription factor 1. (755 aa)
MSTNMyostatin. (375 aa)
C1QL4Complement C1q like 4. (238 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
B4GALT7Beta-1,4-galactosyltransferase 7. (379 aa)
MED25Mediator complex subunit 25. (842 aa)
TRIM32Tripartite motif containing 32. (653 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3710 aa)
PARP10Poly [ADP-ribose] polymerase. (957 aa)
FBXO4F-box protein 4. (387 aa)
PAWRPro-apoptotic WT1 regulator. (344 aa)
A0A4W2CHZ4Ig-like domain-containing protein. (299 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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