STRINGSTRING
AGR2 AGR2 AHI1 AHI1 EPHB3 EPHB3 FGF10 FGF10 HIF1A HIF1A TP63 TP63 SIX2 SIX2 SHOX2 SHOX2 PDGFRA PDGFRA STRA6 STRA6 WNT5A WNT5A EPB41L5 EPB41L5 SHH SHH SMAD3 SMAD3 BMP4 BMP4 SOX17 SOX17 NKX2-3 NKX2-3 NOTCH1 NOTCH1 SFRP1 SFRP1 SFRP2 SFRP2 HLX HLX TCF21 TCF21 ID2 ID2 GLI3 GLI3 A0A4W2CTH5 A0A4W2CTH5 IHH IHH WNT11 WNT11 NIPBL NIPBL FOXF1 FOXF1 SOX10 SOX10 BCL2 BCL2 NODAL NODAL SMAD2 SMAD2 HNF1B HNF1B CTNNB1 CTNNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
AHI1Abelson helper integration site 1. (1163 aa)
EPHB3EPH receptor B3. (997 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SIX2SIX homeobox 2. (296 aa)
SHOX2Short stature homeobox 2. (331 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
STRA6Stimulated by retinoic acid 6. (668 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (726 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SOX17SRY-box transcription factor 17. (410 aa)
NKX2-3NK2 homeobox 3. (367 aa)
NOTCH1Notch receptor 1. (2533 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
HLXH2.0 like homeobox. (486 aa)
TCF21Transcription factor 21. (179 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
GLI3GLI family zinc finger 3. (1587 aa)
A0A4W2CTH5RRM domain-containing protein. (189 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NIPBLNipped-B protein. (2698 aa)
FOXF1Forkhead box F1. (481 aa)
SOX10SRY-box transcription factor 10. (469 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
NODALNodal growth differentiation factor. (346 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
HNF1BHNF1 homeobox B. (558 aa)
CTNNB1Catenin beta 1. (774 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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