STRINGSTRING
DBX1 DBX1 OLIG1 OLIG1 SOX9 SOX9 MNX1 MNX1 GSX1 GSX1 FEZF2 FEZF2 CTNNB1 CTNNB1 ZNF521 ZNF521 SUFU SUFU NKX6-2 NKX6-2 ISL2 ISL2 EHMT2 EHMT2 JAG2 JAG2 POU3F2 POU3F2 TGFBR1 TGFBR1 IHH IHH GLI3 GLI3 DLL4 DLL4 ID2 ID2 DLL1 DLL1 POU4F1 POU4F1 PTF1A PTF1A MYT1L MYT1L DLX1 DLX1 GBX1 GBX1 SIX1 SIX1 DLX2 DLX2 GSX2 GSX2 CDC42 CDC42 ASCL1 ASCL1 HOXC10 HOXC10 SMAD4 SMAD4 NOTCH1 NOTCH1 PROX1 PROX1 FOXN4 FOXN4 EPOP EPOP PAX6 PAX6 BCL11B BCL11B EYA1 EYA1 NKX2-1 NKX2-1 PRRX1 PRRX1 FEV FEV BMP4 BMP4 FOXA1 FOXA1 FOXG1 FOXG1 SHH SHH HOXD10 HOXD10 OLIG2 OLIG2 LHX3 LHX3 ISL1 ISL1 DMRT3 DMRT3 TBR1 TBR1 OLIG3 OLIG3 LBX1 LBX1 DMRTA2 DMRTA2 ATOH1 ATOH1 WNT1 WNT1 TLX3 TLX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBX1Developing brain homeobox 1. (345 aa)
OLIG1Oligodendrocyte transcription factor 1. (266 aa)
SOX9SRY-box transcription factor 9. (524 aa)
MNX1Motor neuron and pancreas homeobox 1. (403 aa)
GSX1GS homeobox 1. (335 aa)
FEZF2FEZ family zinc finger 2. (459 aa)
CTNNB1Catenin beta 1. (774 aa)
ZNF521Zinc finger protein 521. (1311 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
NKX6-2NK6 homeobox 2. (278 aa)
ISL2ISL LIM homeobox 2. (359 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
POU3F2POU class 3 homeobox 2. (414 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
GLI3GLI family zinc finger 3. (1587 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
POU4F1POU domain protein. (421 aa)
PTF1APancreas associated transcription factor 1a. (326 aa)
MYT1LMyelin transcription factor 1 like. (1205 aa)
DLX1Distal-less homeobox 1. (255 aa)
GBX1Gastrulation brain homeobox 1. (365 aa)
SIX1SIX homeobox 1. (284 aa)
DLX2Distal-less homeobox 2. (331 aa)
GSX2GS homeobox 2. (305 aa)
CDC42Cell division cycle 42. (191 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
HOXC10Homeobox C10. (373 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
NOTCH1Notch receptor 1. (2533 aa)
PROX1Prospero homeobox 1. (738 aa)
FOXN4Forkhead box N4. (546 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
PAX6Paired box 6. (455 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (903 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (700 aa)
NKX2-1NK2 homeobox 1. (408 aa)
PRRX1Paired related homeobox 1. (245 aa)
FEVFEV transcription factor, ETS family member. (239 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FOXA1Forkhead box A1. (468 aa)
FOXG1Forkhead box G1. (491 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
HOXD10Homeobox D10. (410 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
LHX3LIM homeobox 3. (403 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (568 aa)
TBR1T-box brain transcription factor 1. (682 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
LBX1Ladybird homeobox 1. (282 aa)
DMRTA2DMRT like family A2. (535 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TLX3T cell leukemia homeobox 3. (338 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.