STRINGSTRING
NELFB NELFB SOX8 SOX8 HESX1 HESX1 CTNNB1 CTNNB1 HNF1B HNF1B GATA6 GATA6 MSI2 MSI2 CDH2 CDH2 SEMA3B SEMA3B BCL2 BCL2 RUNX2 RUNX2 RET RET SOX10 SOX10 KLHL12 KLHL12 HOXB4 HOXB4 KBTBD8 KBTBD8 MYOCD MYOCD LIF LIF PSMD11 PSMD11 RADIL RADIL TBX3 TBX3 WNT7A WNT7A NANOG NANOG GSC GSC WNT3 WNT3 ZFP36 ZFP36 UFL1 UFL1 EFNB1 EFNB1 A0A4W2CIL9 A0A4W2CIL9 SRF SRF XRCC5 XRCC5 SHC4 SHC4 MAPK1 MAPK1 EXT1 EXT1 SEMA4F SEMA4F CITED2 CITED2 HTR2B HTR2B SOX18 SOX18 LMBR1L LMBR1L PHACTR4 PHACTR4 SLC9A1 SLC9A1 OSR1 OSR1 EZH2 EZH2 HOXA7 HOXA7 HOXD4 HOXD4 SIX1 SIX1 LRP6 LRP6 REST REST KIT KIT CDC42 CDC42 TCOF1 TCOF1 SEMA4C SEMA4C TWIST1 TWIST1 TBXT TBXT TAL1 TAL1 SEMA6B SEMA6B HES1 HES1 ALX1 ALX1 SETD2 SETD2 SMAD4 SMAD4 A0A4W2DQU8 A0A4W2DQU8 SEMA6C SEMA6C BBS12 BBS12 FOXO4 FOXO4 MED1 MED1 TBX2 TBX2 SFRP2 SFRP2 ACVR1 ACVR1 SFRP1 SFRP1 SEMA3F SEMA3F NOTCH1 NOTCH1 GPM6A GPM6A SEMA3D SEMA3D SH2B3 SH2B3 EPOP EPOP SEMA3G SEMA3G NRP1 NRP1 EPCAM EPCAM CORO1C CORO1C FN1 FN1 RDH10 RDH10 ELL3 ELL3 SEMA6D SEMA6D SOX17 SOX17 FGF2 FGF2 ZNF281 ZNF281 PTPRC PTPRC HMGA2 HMGA2 EDNRB EDNRB FOXA1 FOXA1 SEMA5A SEMA5A MLLT3 MLLT3 FAM172A FAM172A MTF2 MTF2 PHF19 PHF19 SHH SHH SEMA6A SEMA6A GBX2 GBX2 METTL5 METTL5 SEMA4A SEMA4A ANXA6 ANXA6 SEMA3E SEMA3E SEMA3A SEMA3A EDNRA EDNRA GDNF GDNF KITLG KITLG CDX2 CDX2 ISL1 ISL1 JAG1 JAG1 PUM1 PUM1 FZD1 FZD1 NOLC1 NOLC1 CDK6 CDK6 NRTN NRTN MSX1 MSX1 SEMA4D SEMA4D SP7 SP7 GREM1 GREM1 DNMT3L DNMT3L SEMA4B SEMA4B ESR1 ESR1 SETD6 SETD6 ALDH1A2 ALDH1A2 ITGB1 ITGB1 ERCC2 ERCC2 WNT10A WNT10A SEMA3C SEMA3C SMO SMO TP63 TP63 BATF BATF SNAI2 SNAI2 ERBB4 ERBB4 PHF5A PHF5A TGFB2 TGFB2 HIF1A HIF1A FRZB FRZB SEMA7A SEMA7A PHOX2B PHOX2B SEMA5B SEMA5B SEMA4G SEMA4G DMRTA2 DMRTA2 PEF1 PEF1 TP53 TP53 MAPK3 MAPK3 CYP26C1 CYP26C1 NOG NOG EDN1 EDN1 HAND2 HAND2 MEF2C MEF2C JARID2 JARID2 SOX21 SOX21 BMPR1A BMPR1A SOX9 SOX9 NRP2 NRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NELFBNegative elongation factor complex member B. (629 aa)
SOX8SRY-box transcription factor 8. (534 aa)
HESX1HESX homeobox 1. (215 aa)
CTNNB1Catenin beta 1. (774 aa)
HNF1BHNF1 homeobox B. (558 aa)
GATA6GATA binding protein 6. (662 aa)
MSI2Musashi RNA binding protein 2. (404 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (1318 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (753 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
RUNX2RUNX family transcription factor 2. (527 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
SOX10SRY-box transcription factor 10. (469 aa)
KLHL12Kelch like family member 12. (568 aa)
HOXB4Homeobox B4. (251 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
MYOCDMyocardin. (981 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (437 aa)
RADILRap associating with DIL domain. (1485 aa)
TBX3T-box transcription factor 3. (748 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
NANOGHomeobox domain-containing protein. (285 aa)
GSCGoosecoid homeobox. (266 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
UFL1UFM1 specific ligase 1. (792 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (377 aa)
A0A4W2CIL9Uncharacterized protein. (423 aa)
SRFSerum response factor. (509 aa)
XRCC5X-ray repair cross complementing 5. (813 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
HTR2B5-hydroxytryptamine receptor 2B. (538 aa)
SOX18SRY-box transcription factor 18. (389 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (779 aa)
HOXA7Homeobox A7. (238 aa)
HOXD4Homeobox D4. (257 aa)
SIX1SIX homeobox 1. (284 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1644 aa)
RESTRE1 silencing transcription factor. (1004 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
CDC42Cell division cycle 42. (191 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1458 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1119 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
TBXTT-box transcription factor T. (435 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (1019 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ALX1ALX homeobox 1. (326 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
A0A4W2DQU8Uncharacterized protein. (300 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (956 aa)
BBS12Bardet-Biedl syndrome 12. (710 aa)
FOXO4Forkhead box O4. (511 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
TBX2T-box transcription factor 2. (714 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (793 aa)
NOTCH1Notch receptor 1. (2533 aa)
GPM6AGlycoprotein M6A. (317 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (776 aa)
SH2B3SH2B adaptor protein 3. (587 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (493 aa)
FN1Fibronectin 1. (2601 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
SOX17SRY-box transcription factor 17. (410 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ZNF281Zinc finger protein 281. (893 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
HMGA2Uncharacterized protein. (109 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
FOXA1Forkhead box A1. (468 aa)
SEMA5ASemaphorin 5A. (1084 aa)
MLLT3MLLT3 super elongation complex subunit. (567 aa)
FAM172AFamily with sequence similarity 172 member A. (465 aa)
MTF2Metal response element binding transcription factor 2. (593 aa)
PHF19PHD finger protein 19. (580 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
GBX2Gastrulation brain homeobox 2. (349 aa)
METTL5Methyltransferase like 5. (209 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (851 aa)
ANXA6Annexin. (751 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (763 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (249 aa)
CDX2Caudal type homeobox 2. (306 aa)
ISL1ISL LIM homeobox 1. (349 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PUM1Pumilio RNA binding family member 1. (1189 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (762 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NRTNNeurturin. (197 aa)
MSX1Msh homeobox 1. (366 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
SP7Sp7 transcription factor. (431 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
DNMT3LPHD-type domain-containing protein. (386 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (859 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (450 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PHF5APHD finger protein 5A. (110 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
FRZBFrizzled related protein. (325 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
SEMA5BSemaphorin 5B. (1113 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
DMRTA2DMRT like family A2. (535 aa)
PEF1Penta-EF-hand domain containing 1. (287 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EDN1Endothelin 1. (202 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1252 aa)
SOX21SRY-box transcription factor 21. (277 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SOX9SRY-box transcription factor 9. (524 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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