node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAXX | PARK7 | A0A4W2C1I9 | A0A4W2EL41 | Death domain associated protein. | Parkinsonism associated deglycase. | 0.918 |
DDX5 | EP300 | A0A4W2E058 | A0A4W2C026 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | E1A binding protein p300. | 0.677 |
DDX5 | PRMT2 | A0A4W2E058 | A0A4W2E256 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. | 0.419 |
DDX5 | PRPF6 | A0A4W2E058 | A0A4W2EIE2 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | Pre-mRNA processing factor 6. | 0.938 |
EP300 | DDX5 | A0A4W2C026 | A0A4W2E058 | E1A binding protein p300. | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.677 |
EP300 | KDM1A | A0A4W2C026 | A0A4W2DUL7 | E1A binding protein p300. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.648 |
EP300 | NSD1 | A0A4W2C026 | A0A4W2ETM8 | E1A binding protein p300. | Nuclear receptor binding SET domain protein 1. | 0.472 |
EP300 | SMARCA4 | A0A4W2C026 | A0A4W2H3C7 | E1A binding protein p300. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. | 0.549 |
EP300 | SNW1 | A0A4W2C026 | A0A4W2EQP0 | E1A binding protein p300. | SNW domain containing 1. | 0.661 |
KDM1A | EP300 | A0A4W2DUL7 | A0A4W2C026 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | E1A binding protein p300. | 0.648 |
KDM1A | KDM3A | A0A4W2DUL7 | A0A4W2CCP6 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Lysine demethylase 3A. | 0.520 |
KDM1A | PKN1 | A0A4W2DUL7 | A0A4W2F166 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Protein kinase N1. | 0.595 |
KDM3A | KDM1A | A0A4W2CCP6 | A0A4W2DUL7 | Lysine demethylase 3A. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.520 |
KDM3A | SMARCA4 | A0A4W2CCP6 | A0A4W2H3C7 | Lysine demethylase 3A. | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. | 0.851 |
NSD1 | EP300 | A0A4W2ETM8 | A0A4W2C026 | Nuclear receptor binding SET domain protein 1. | E1A binding protein p300. | 0.472 |
PARK7 | DAXX | A0A4W2EL41 | A0A4W2C1I9 | Parkinsonism associated deglycase. | Death domain associated protein. | 0.918 |
PKN1 | KDM1A | A0A4W2F166 | A0A4W2DUL7 | Protein kinase N1. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.595 |
PRMT2 | DDX5 | A0A4W2E256 | A0A4W2E058 | Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.419 |
PRPF6 | DDX5 | A0A4W2EIE2 | A0A4W2E058 | Pre-mRNA processing factor 6. | DEAD-box helicase 5; Belongs to the DEAD box helicase family. | 0.938 |
PRPF6 | SNW1 | A0A4W2EIE2 | A0A4W2EQP0 | Pre-mRNA processing factor 6. | SNW domain containing 1. | 0.432 |