(42 nodes) Negative regulation of protein secretion network (Bos indicus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
	RAB11FIP1	Uncharacterized protein. (712 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (133 aa)
	KCNJ11	Potassium voltage-gated channel subfamily J member 11. (388 aa)
	NDUFAF2	NADH:ubiquinone oxidoreductase complex assembly factor 2. (222 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	ADTRP	Androgen dependent TFPI regulating protein. (230 aa)
	FOXO1	Forkhead box O1. (604 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (741 aa)
	FAM3D	Family with sequence similarity 3 member D. (223 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	RHBDF1	Rhomboid 5 homolog 1. (865 aa)
	INHBB	Inhibin subunit beta B. (398 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	ADRA2A	Adrenoceptor alpha 2A. (468 aa)
	SFRP1	Secreted frizzled related protein 1. (307 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (363 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (466 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	RHBDF2	Rhomboid 5 homolog 2. (830 aa)
	A0A4W2E766	Uncharacterized protein. (73 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1146 aa)
	CHGA	Chromogranin A. (488 aa)
	VSNL1	Visinin like 1. (293 aa)
	STXBP5L	Syntaxin binding protein 5 like. (1233 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (887 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
	PFKL	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	KLF7	Kruppel like factor 7. (302 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (479 aa)
	REST	RE1 silencing transcription factor. (1004 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	KCNB1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
	MIDN	Midnolin. (496 aa)
	FRMD4A	FERM domain containing 4A. (1068 aa)
	APOE	Apolipoprotein E. (349 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	A0A4W2E766	A0A4W2BND6	A0A4W2E766	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.819
A0A4W2BND6	APOE	A0A4W2BND6	A0A4W2D0I1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Apolipoprotein E.	0.521
A0A4W2BND6	CHGA	A0A4W2BND6	A0A4W2EHQ2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Chromogranin A.	0.420
A0A4W2BND6	FOXO1	A0A4W2BND6	A0A4W2BQW9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box O1.	0.541
A0A4W2BND6	GHRL	A0A4W2BND6	A0A4W2CA24	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ghrelin and obestatin prepropeptide.	0.830
A0A4W2BND6	HMGCR	A0A4W2BND6	A0A4W2EU89	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.420
A0A4W2BND6	SREBF1	A0A4W2BND6	A0A4W2EFD2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Sterol regulatory element binding transcription factor 1.	0.422
A0A4W2C5I5	A0A4W2E766	A0A4W2C5I5	A0A4W2E766	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.819
A0A4W2C5I5	APOE	A0A4W2C5I5	A0A4W2D0I1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Apolipoprotein E.	0.521
A0A4W2C5I5	CHGA	A0A4W2C5I5	A0A4W2EHQ2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Chromogranin A.	0.420
A0A4W2C5I5	FOXO1	A0A4W2C5I5	A0A4W2BQW9	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box O1.	0.541
A0A4W2C5I5	GHRL	A0A4W2C5I5	A0A4W2CA24	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ghrelin and obestatin prepropeptide.	0.830
A0A4W2C5I5	HMGCR	A0A4W2C5I5	A0A4W2EU89	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.420
A0A4W2C5I5	SREBF1	A0A4W2C5I5	A0A4W2EFD2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Sterol regulatory element binding transcription factor 1.	0.422
A0A4W2E766	A0A4W2BND6	A0A4W2E766	A0A4W2BND6	Uncharacterized protein.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.819
A0A4W2E766	A0A4W2C5I5	A0A4W2E766	A0A4W2C5I5	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.819
A0A4W2E766	CHGA	A0A4W2E766	A0A4W2EHQ2	Uncharacterized protein.	Chromogranin A.	0.582
A0A4W2E766	DRD2	A0A4W2E766	A0A4W2BYK1	Uncharacterized protein.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.883
A0A4W2E766	DRD3	A0A4W2E766	A0A4W2DGD2	Uncharacterized protein.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.512
A0A4W2E766	DRD4	A0A4W2E766	A0A4W2DTC1	Uncharacterized protein.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.456

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