STRINGSTRING
DKKL1 DKKL1 A0A4W2C9G4 A0A4W2C9G4 A0A4W2C692 A0A4W2C692 SEC14L4 SEC14L4 BMP5 BMP5 NR1D1 NR1D1 BMP6 BMP6 A0A4W2BS45 A0A4W2BS45 SEC14L5 SEC14L5 LHCGR LHCGR LPCAT3 LPCAT3 LEP LEP A0A4W2CXU6 A0A4W2CXU6 APOE APOE CGA CGA DHH DHH GFI1 GFI1 FGFR4 FGFR4 INSIG1 INSIG1 REST REST FGF1 FGF1 INSIG2 INSIG2 EGR1 EGR1 CLCN2 CLCN2 SCAP SCAP PDE8B PDE8B STAR STAR SIRT1 SIRT1 PROX1 PROX1 MALRD1 MALRD1 SEC14L2 SEC14L2 DKK3 DKK3 SNAI1 SNAI1 APOB APOB TNF TNF SREBF1 SREBF1 A0A4W2EG68 A0A4W2EG68 SEC14L3 SEC14L3 IFNG IFNG H6PD H6PD A0A4W2EQN1 A0A4W2EQN1 DDX20 DDX20 A0A4W2EWY4 A0A4W2EWY4 NR3C1 NR3C1 A0A4W2F271 A0A4W2F271 CYP27C1 CYP27C1 CYP27B1 CYP27B1 BMP2 BMP2 ATP1A1 ATP1A1 SNAI2 SNAI2 ARMC5 ARMC5 ABCG4 ABCG4 A0A4W2CDY2 A0A4W2CDY2 STARD4 STARD4 IGFBP7 IGFBP7 SF1 SF1 ASAH1 ASAH1 CYP7A1 CYP7A1 NFKB1 NFKB1 FGF19 FGF19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DKKL1Dickkopf like acrosomal protein 1. (277 aa)
A0A4W2C9G4Uncharacterized protein. (232 aa)
A0A4W2C692Uncharacterized protein. (396 aa)
SEC14L4SEC14 like lipid binding 4. (406 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
BMP6Bone morphogenetic protein 6. (525 aa)
A0A4W2BS45Uncharacterized protein. (111 aa)
SEC14L5SEC14 like lipid binding 5. (722 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (485 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
A0A4W2CXU6Cys_knot domain-containing protein. (106 aa)
APOEApolipoprotein E. (349 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (150 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (401 aa)
GFI1Growth factor independent 1 transcriptional repressor. (436 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (299 aa)
RESTRE1 silencing transcription factor. (1004 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (266 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
CLCN2Chloride channel protein. (911 aa)
SCAPSREBF chaperone. (1279 aa)
PDE8BPhosphodiesterase. (885 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (350 aa)
SIRT1Sirtuin 1. (734 aa)
PROX1Prospero homeobox 1. (738 aa)
MALRD1MAM and LDL receptor class A domain containing 1. (2180 aa)
SEC14L2Uncharacterized protein. (403 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (458 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
APOBApolipoprotein B. (4567 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1146 aa)
A0A4W2EG68Uncharacterized protein. (347 aa)
SEC14L3SEC14 like lipid binding 3. (400 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (804 aa)
A0A4W2EQN1Phorbol-ester/DAG-type domain-containing protein. (322 aa)
DDX20DEAD-box helicase 20. (875 aa)
A0A4W2EWY4Uncharacterized protein. (214 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (782 aa)
A0A4W2F271START domain-containing protein. (319 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ARMC5Armadillo repeat containing 5. (940 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
A0A4W2CDY2Cys_knot domain-containing protein. (129 aa)
STARD4StAR related lipid transfer domain containing 4. (260 aa)
IGFBP7Insulin like growth factor binding protein 7. (282 aa)
SF1Splicing factor 1. (639 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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