STRINGSTRING
PCM1 PCM1 APBB3 APBB3 C1QTNF12 C1QTNF12 PIK3R2 PIK3R2 XPO4 XPO4 PDX1 PDX1 A0A4W2BLR6 A0A4W2BLR6 YWHAE YWHAE A0A4W2BND6 A0A4W2BND6 CAMK1 CAMK1 GPR27 GPR27 CLN3 CLN3 TSG101 TSG101 CHP2 CHP2 MYOM1 MYOM1 TRH TRH PPP3CB PPP3CB MCU MCU HYAL2 HYAL2 EXPH5 EXPH5 PLA2G6 PLA2G6 MIEF2 MIEF2 BAG3 BAG3 MYO1C MYO1C TLR2 TLR2 MYH10 MYH10 A0A4W2C5I5 A0A4W2C5I5 TUNAR TUNAR CEMIP CEMIP PIK3R1 PIK3R1 BAD BAD GHRL GHRL PARD6A PARD6A ZFAND1 ZFAND1 RIPOR1 RIPOR1 IL1A IL1A FFAR1 FFAR1 PRKCE PRKCE AKT2 AKT2 TGFB1 TGFB1 ANXA13 ANXA13 CFTR CFTR MIEF1 MIEF1 FGG FGG ACSL3 ACSL3 SRI SRI MFF MFF MAVS MAVS GAS6 GAS6 GLI3 GLI3 SFN SFN IRS2 IRS2 CDH1 CDH1 CNST CNST PPID PPID OAZ2 OAZ2 LEP LEP GSK3B GSK3B HCLS1 HCLS1 CTDSPL2 CTDSPL2 TOMM7 TOMM7 RAPGEF3 RAPGEF3 PFKM PFKM EZR EZR FRMD4A FRMD4A OAZ1 OAZ1 TLR4 TLR4 TMEM30B TMEM30B PDZK1 PDZK1 PDCD10 PDCD10 KCNB1 KCNB1 CDK5 CDK5 ZC3H12A ZC3H12A ECT2 ECT2 SLC35D3 SLC35D3 CAPN10 CAPN10 TM9SF4 TM9SF4 DMAP1 DMAP1 ATP13A2 ATP13A2 MPC2 MPC2 ANG ANG DNM1L DNM1L SOX4 SOX4 SIRT6 SIRT6 WLS WLS TCAF1 TCAF1 A0A4W2DP37 A0A4W2DP37 SLC51B SLC51B PRKCD PRKCD ANO1 ANO1 RPH3AL RPH3AL EXOC1 EXOC1 SORL1 SORL1 GPER1 GPER1 GPLD1 GPLD1 ADAM9 ADAM9 ERBB2 ERBB2 CD2AP CD2AP TPR TPR GPR68 GPR68 RBM22 RBM22 ATP2C1 ATP2C1 P2RX7 P2RX7 A0A4W2E2B7 A0A4W2E2B7 VPS28 VPS28 ADCY8 ADCY8 RBP4 RBP4 GSK3A GSK3A NLGN2 NLGN2 A0A4W2E5C7 A0A4W2E5C7 BAIAP3 BAIAP3 NR1H2 NR1H2 A0A4W2E766 A0A4W2E766 CEP131 CEP131 AACS AACS SEC16B SEC16B RFX6 RFX6 ANP32B ANP32B C2CD2L C2CD2L C1QTNF3 C1QTNF3 ITGB1BP1 ITGB1BP1 ICE1 ICE1 TNF TNF TARDBP TARDBP IFNG IFNG IPO5 IPO5 UBR5 UBR5 VSNL1 VSNL1 ERGIC3 ERGIC3 ARF6 ARF6 FYN FYN CHP1 CHP1 OR51E2 OR51E2 PRR5L PRR5L EDEM2 EDEM2 BLK BLK GLUD1 GLUD1 TMED10 TMED10 TGFB3 TGFB3 PSEN1 PSEN1 ARHGEF5 ARHGEF5 PPM1A PPM1A AKAP5 AKAP5 SHH SHH C2CD5 C2CD5 HDAC3 HDAC3 TM7SF3 TM7SF3 ABCG1 ABCG1 EFCAB7 EFCAB7 NNAT NNAT FBXW9 FBXW9 HMMR HMMR A0A4W2F3Y4 A0A4W2F3Y4 TREM2 TREM2 PLK3 PLK3 SAR1B SAR1B B3GAT3 B3GAT3 GHRH GHRH JUP JUP EDEM1 EDEM1 FGB FGB ZPR1 ZPR1 CD81 CD81 IGF1 IGF1 HSPA1L HSPA1L CIB1 CIB1 PTPN22 PTPN22 LRRC8A LRRC8A TMEM30A TMEM30A DOC2B DOC2B PRKAA1 PRKAA1 SERP1 SERP1 HIF1A HIF1A TGFB2 TGFB2 A0A4W2HBP3 A0A4W2HBP3 HRAS HRAS OAZ3 OAZ3 FBXW7 FBXW7 PRKD1 PRKD1 GOLPH3L GOLPH3L TRIM28 TRIM28 BBC3 BBC3 SMO SMO ANKRD1 ANKRD1 GCG GCG TOMM7-2 TOMM7-2 PRKACA PRKACA NR1H4 NR1H4 GCK GCK SAR1A SAR1A TCF7L2 TCF7L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCM1Pericentriolar material 1. (2220 aa)
APBB3Amyloid beta precursor protein binding family B member 3. (493 aa)
C1QTNF12C1q and TNF related 12. (299 aa)
PIK3R2Uncharacterized protein. (724 aa)
XPO4Exportin 4. (1152 aa)
PDX1Pancreatic and duodenal homeobox 1. (285 aa)
A0A4W2BLR6C2 domain-containing protein. (389 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (268 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (369 aa)
GPR27G protein-coupled receptor 27. (379 aa)
CLN3Battenin. (460 aa)
TSG101UEV domain-containing protein. (394 aa)
CHP2Calcineurin like EF-hand protein 2. (258 aa)
MYOM1Myomesin 1. (1657 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (241 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
MCUMitochondrial calcium uniporter. (355 aa)
HYAL2Hyaluronidase. (473 aa)
EXPH5Exophilin 5. (1812 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
MIEF2Mitochondrial elongation factor 2. (454 aa)
BAG3BCL2 associated athanogene 3. (585 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (861 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
CEMIPCell migration inducing hyaluronidase 1. (1416 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
GHRLGhrelin and obestatin prepropeptide. (133 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1330 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
ANXA13Annexin. (365 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
FGGFibrinogen gamma chain. (443 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
SRISorcin. (198 aa)
MFFMitochondrial fission factor. (409 aa)
MAVSMitochondrial antiviral signaling protein. (615 aa)
GAS6Growth arrest specific 6. (671 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
IRS2Insulin receptor substrate 2. (1325 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
CNSTConsortin, connexin sorting protein. (720 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
OAZ2Ornithine decarboxylase antizyme 2. (177 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (485 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
TOMM7Uncharacterized protein. (59 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
EZREzrin. (638 aa)
FRMD4AFERM domain containing 4A. (1068 aa)
OAZ1Ornithine decarboxylase antizyme 1. (225 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (353 aa)
PDZK1PDZ domain containing 1. (732 aa)
PDCD10Programmed cell death 10. (212 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (583 aa)
ECT2Epithelial cell transforming 2. (944 aa)
SLC35D3Solute carrier family 35 member D3. (423 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (645 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (513 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1171 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
ANGRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (165 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
SOX4SRY-box transcription factor 4. (501 aa)
SIRT6Sirtuin 6. (391 aa)
WLSWnt ligand secretion mediator. (564 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
A0A4W2DP37Uncharacterized protein. (114 aa)
SLC51BSolute carrier family 51 beta subunit. (130 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ANO1Anoctamin. (1057 aa)
RPH3ALRabphilin 3A like (without C2 domains). (374 aa)
EXOC1Exocyst complex component 1. (928 aa)
SORL1Sortilin related receptor 1. (2211 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (843 aa)
ADAM9ADAM metallopeptidase domain 9. (934 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
CD2APCD2 associated protein. (766 aa)
TPRTranslocated promoter region, nuclear basket protein. (2444 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (383 aa)
RBM22RNA binding motif protein 22. (420 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (974 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
A0A4W2E2B7Uncharacterized protein. (192 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
RBP4Retinol binding protein 4; Belongs to the calycin superfamily. Lipocalin family. (314 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
NLGN2Neuroligin 2. (835 aa)
A0A4W2E5C7UEV domain-containing protein. (389 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (455 aa)
A0A4W2E766Uncharacterized protein. (73 aa)
CEP131Centrosomal protein 131. (1154 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1054 aa)
RFX6Regulatory factor X6. (927 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (269 aa)
C2CD2LC2CD2 like. (707 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2172 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
TARDBPTAR DNA binding protein. (414 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IPO5Importin 5. (1097 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
VSNL1Visinin like 1. (293 aa)
ERGIC3ERGIC and golgi 3. (394 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
FYNTyrosine-protein kinase. (537 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
OR51E2Olfactory receptor. (320 aa)
PRR5LProline rich 5 like. (644 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
BLKTyrosine-protein kinase. (524 aa)
GLUD1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa)
TMED10Transmembrane p24 trafficking protein 10. (219 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1655 aa)
PPM1APPM-type phosphatase domain-containing protein. (454 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
C2CD5C2 calcium dependent domain containing 5. (1137 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ABCG1ATP binding cassette subfamily G member 1. (679 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
NNATUncharacterized protein. (125 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
HMMRHyaluronan mediated motility receptor. (854 aa)
A0A4W2F3Y4Uncharacterized protein. (92 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
GHRHGrowth hormone releasing hormone. (106 aa)
JUPJunction plakoglobin. (745 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (658 aa)
FGBFibrinogen beta chain. (490 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CD81Tetraspanin. (236 aa)
IGF1Insulin like growth factor 1. (188 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
CIB1Calcium and integrin binding 1. (191 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (808 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (400 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (197 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
A0A4W2HBP3CARD_2 domain-containing protein. (65 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
OAZ3Ornithine decarboxylase antizyme 3. (240 aa)
FBXW7F-box and WD repeat domain containing 7. (706 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
TRIM28Tripartite motif containing 28. (838 aa)
BBC3Uncharacterized protein. (193 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
GCGGlucagon. (180 aa)
TOMM7-2Uncharacterized protein. (55 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
GCKPhosphotransferase. (466 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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