STRINGSTRING
ACACB ACACB TK1 TK1 TRPA1 TRPA1 RIPOR2 RIPOR2 SLC1A2 SLC1A2 KCNS1 KCNS1 NLRC4 NLRC4 GNMT GNMT KCNA1 KCNA1 KCNA5 KCNA5 PRMT8 PRMT8 KCNA6 KCNA6 ACACA ACACA KCNG4 KCNG4 KCTD11 KCTD11 SUB1 SUB1 BEND3 BEND3 KCNA4 KCNA4 KCTD19 KCTD19 SHKBP1 SHKBP1 KCNG3 KCNG3 ALS2 ALS2 KCTD2 KCTD2 A0A4W2F2E6 A0A4W2F2E6 A0A4W2F0Q7 A0A4W2F0Q7 A0A4W2EY41 A0A4W2EY41 KCNC4 KCNC4 AQP2 AQP2 SCARA5 SCARA5 POLQ POLQ BCL10 BCL10 TGM2 TGM2 KCNA7 KCNA7 A0A4W2EFI8 A0A4W2EFI8 CBY1 CBY1 SLC1A5 SLC1A5 CALHM1 CALHM1 PNPT1 PNPT1 TDO2 TDO2 SHMT2 SHMT2 CARD9 CARD9 ME1 ME1 KCNV1 KCNV1 NLRP1 NLRP1 KCNRG KCNRG KCTD3 KCTD3 ALDH9A1 ALDH9A1 A0A4W2DZW8 A0A4W2DZW8 TP53BP1 TP53BP1 BLM BLM PRF1 PRF1 KCNMA1 KCNMA1 KCNC1 KCNC1 NLRP6 NLRP6 MSR1 MSR1 G3BP2 G3BP2 VSTM5 VSTM5 MLKL MLKL A0A4W2DPN4 A0A4W2DPN4 MAT1A MAT1A KCND3 KCND3 KCNA2 KCNA2 AQP11 AQP11 TRIM72 TRIM72 APPL2 APPL2 KCTD16 KCTD16 KCTD6 KCTD6 MCOLN1 MCOLN1 CRTC2 CRTC2 TRPM2 TRPM2 THG1L THG1L KCTD8 KCTD8 A0A4W2DFD9 A0A4W2DFD9 FUS FUS ROM1 ROM1 AQP4 AQP4 ATL3 ATL3 KCTD21 KCTD21 RNF135 RNF135 KCTD13 KCTD13 KCTD4 KCTD4 KCTD1 KCTD1 EHD1 EHD1 MICU1 MICU1 PKD2L1 PKD2L1 GSDMD GSDMD PRPH2 PRPH2 PKD2 PKD2 CBR4 CBR4 KCNC2 KCNC2 CRTC1 CRTC1 COMP COMP ECT2 ECT2 SYCP1 SYCP1 ZNF746 ZNF746 KCNB1 KCNB1 KCTD9 KCTD9 APIP APIP GLRA3 GLRA3 PXDN PXDN SIGMAR1 SIGMAR1 SSBP1 SSBP1 PRMT1 PRMT1 KCNA10 KCNA10 ELAVL1 ELAVL1 KCNJ2 KCNJ2 LETM1 LETM1 KCNS3 KCNS3 EHD4 EHD4 TRMT61B TRMT61B KCTD15 KCTD15 SAMHD1 SAMHD1 ATL1 ATL1 MIP MIP CLYBL CLYBL KCND2 KCND2 UPB1 UPB1 SPAST SPAST EVL EVL A0A4W2CNX0 A0A4W2CNX0 TMEM120A TMEM120A PRND PRND PRNP PRNP PYCARD PYCARD CHMP2A CHMP2A USO1 USO1 KCTD17 KCTD17 OSBPL2 OSBPL2 A0A4W2I3U5 A0A4W2I3U5 KCTD14 KCTD14 A0A4W2I2L4 A0A4W2I2L4 TNFAIP1 TNFAIP1 CEP57 CEP57 STEAP4 STEAP4 RNF112 RNF112 KCNA3 KCNA3 HSD17B10 HSD17B10 KCNC3 KCNC3 NACC2 NACC2 EHD3 EHD3 ZBTB1 ZBTB1 KCTD10 KCTD10 TRPM4 TRPM4 USP16 USP16 ATL2 ATL2 CRYZ CRYZ ALDH1A3 ALDH1A3 P2RX3 P2RX3 KCNF1 KCNF1 VASP VASP KCNG1 KCNG1 ALDH1A2 ALDH1A2 CRTC3 CRTC3 KCNB2 KCNB2 KCNV2 KCNV2 CARD11 CARD11 IKZF4 IKZF4 SHMT1 SHMT1 ACOT13 ACOT13 ALOX5AP ALOX5AP HCN1 HCN1 ALAD ALAD C9 C9 KCTD18 KCTD18 JMJD6 JMJD6 KCTD12 KCTD12
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACACBAcetyl-CoA carboxylase beta. (2455 aa)
TK1Thymidine kinase. (238 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
RIPOR2PL48 domain-containing protein. (1065 aa)
SLC1A2Amino acid transporter. (595 aa)
KCNS1Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (529 aa)
NLRC4NLR family CARD domain containing 4. (1017 aa)
GNMTGlycine N-methyltransferase. (312 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (598 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (445 aa)
KCNA6Potassium voltage-gated channel subfamily A member 6; Belongs to the potassium channel family. (528 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
KCNG4Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family. (511 aa)
KCTD11Potassium channel tetramerization domain containing 11. (271 aa)
SUB1SUB1 regulator of transcription. (178 aa)
BEND3BEN domain containing 3. (1005 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (661 aa)
KCTD19Potassium channel tetramerization domain containing 19. (927 aa)
SHKBP1SH3KBP1 binding protein 1. (796 aa)
KCNG3Potassium voltage-gated channel modifier subfamily G member 3; Belongs to the potassium channel family. (425 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa)
KCTD2Potassium channel tetramerization domain containing 2. (264 aa)
A0A4W2F2E6SAM domain-containing protein. (663 aa)
A0A4W2F0Q7Fibrinogen C-terminal domain-containing protein. (323 aa)
A0A4W2EY41Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (418 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (659 aa)
AQP2Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (506 aa)
POLQDNA polymerase theta. (2585 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
TGM2Transglutaminase 2. (687 aa)
KCNA7Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family. (456 aa)
A0A4W2EFI8RRM domain-containing protein. (396 aa)
CBY1Chibby family member 1, beta catenin antagonist. (182 aa)
SLC1A5Amino acid transporter. (539 aa)
CALHM1Calcium homeostasis modulator 1. (344 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (418 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
CARD9Caspase recruitment domain family member 9. (538 aa)
ME1Malic enzyme. (641 aa)
KCNV1Potassium voltage-gated channel modifier subfamily V member 1; Belongs to the potassium channel family. (502 aa)
NLRP1NLR family pyrin domain containing 1. (1410 aa)
KCNRGPotassium channel regulator. (267 aa)
KCTD3Potassium channel tetramerization domain containing 3. (816 aa)
ALDH9A1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (591 aa)
A0A4W2DZW8Fibrinogen C-terminal domain-containing protein. (312 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
BLMBLM RecQ like helicase. (1430 aa)
PRF1Perforin 1. (559 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1276 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
NLRP6NLR family pyrin domain containing 6. (877 aa)
MSR1Macrophage scavenger receptor 1. (454 aa)
G3BP2G3BP stress granule assembly factor 2. (482 aa)
VSTM5V-set and transmembrane domain containing 5. (200 aa)
MLKLMixed lineage kinase domain like pseudokinase. (495 aa)
A0A4W2DPN4TORC_N domain-containing protein. (169 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (493 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
TRIM72Tripartite motif containing 72. (482 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (659 aa)
KCTD16Potassium channel tetramerization domain containing 16. (428 aa)
KCTD6Potassium channel tetramerization domain containing 6. (237 aa)
MCOLN1Mucolipin 1. (653 aa)
CRTC2Uncharacterized protein. (693 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
THG1LtRNA-histidine guanylyltransferase 1 like. (368 aa)
KCTD8Potassium channel tetramerization domain containing 8. (470 aa)
A0A4W2DFD9Uncharacterized protein. (305 aa)
FUSFUS RNA binding protein. (512 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (329 aa)
ATL3Atlastin GTPase 3. (541 aa)
KCTD21Potassium channel tetramerization domain containing 21. (330 aa)
RNF135Ring finger protein 135. (445 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
KCTD4Potassium channel tetramerization domain containing 4. (258 aa)
KCTD1BTB domain-containing protein. (861 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (548 aa)
MICU1Mitochondrial calcium uptake 1. (484 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (773 aa)
GSDMDGasdermin D. (543 aa)
PRPH2Peripherin 2. (346 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (1071 aa)
CBR4Carbonyl reductase 4. (237 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (629 aa)
CRTC1CREB regulated transcription coactivator 1. (653 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ECT2Epithelial cell transforming 2. (944 aa)
SYCP1Synaptonemal complex protein 1. (980 aa)
ZNF746Zinc finger protein 746. (679 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
KCTD9Potassium channel tetramerization domain containing 9. (389 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (257 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
PXDNPeroxidasin. (1479 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (267 aa)
SSBP1Single stranded DNA binding protein 1. (159 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (347 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (686 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
TRMT61BtRNA methyltransferase 61B. (500 aa)
KCTD15Potassium channel tetramerization domain containing 15. (283 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa)
ATL1Atlastin GTPase 1. (601 aa)
MIPMajor intrinsic protein of lens fiber; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
CLYBLCitrate lyase beta like. (341 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
UPB1Beta-ureidopropionase 1. (385 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (613 aa)
EVLEnah/Vasp-like. (455 aa)
A0A4W2CNX0Uncharacterized protein. (494 aa)
TMEM120ATransmembrane protein 120A. (408 aa)
PRNDDoppel protein. (178 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] (264 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
USO1USO1 vesicle transport factor. (965 aa)
KCTD17Potassium channel tetramerization domain containing 17. (307 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (482 aa)
A0A4W2I3U5Uncharacterized protein. (296 aa)
KCTD14Potassium channel tetramerization domain containing 14. (243 aa)
A0A4W2I2L4Fibrinogen C-terminal domain-containing protein. (301 aa)
TNFAIP1TNF alpha induced protein 1. (316 aa)
CEP57Centrosomal protein 57. (499 aa)
STEAP4STEAP4 metalloreductase. (470 aa)
RNF112Ring finger protein 112. (795 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (576 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (734 aa)
NACC2NACC family member 2. (585 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (528 aa)
ZBTB1Zinc finger and BTB domain containing 1. (713 aa)
KCTD10Potassium channel tetramerization domain containing 10. (315 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1207 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (827 aa)
ATL2Atlastin GTPase 2. (625 aa)
CRYZCrystallin zeta. (330 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
KCNF1Potassium voltage-gated channel modifier subfamily F member 1; Belongs to the potassium channel family. (495 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (383 aa)
KCNG1Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family. (514 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (911 aa)
KCNV2Potassium voltage-gated channel modifier subfamily V member 2; Belongs to the potassium channel family. (566 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
IKZF4IKAROS family zinc finger 4. (585 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (497 aa)
ACOT13Acyl-CoA thioesterase 13. (155 aa)
ALOX5APArachidonate 5-lipoxygenase activating protein. (162 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (877 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)
C9Complement C9. (548 aa)
KCTD18Potassium channel tetramerization domain containing 18. (422 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
KCTD12Potassium channel tetramerization domain containing 12. (326 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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