STRINGSTRING
A0A4W2CRB3 A0A4W2CRB3 EPHA7 EPHA7 CORO1A CORO1A A0A4W2BUF7 A0A4W2BUF7 BCL2 BCL2 TFAP2B TFAP2B A0A4W2BZH9 A0A4W2BZH9 CASP7 CASP7 CASP3 CASP3 FAS FAS FADD FADD AKT2 AKT2 PIGT PIGT RAPSN RAPSN DRAXIN DRAXIN AXL AXL TYRO3 TYRO3 POU4F1 POU4F1 CASP9 CASP9 SNCB SNCB ATF2 ATF2 DLX1 DLX1 CDK5 CDK5 BOK BOK NEFL NEFL NCSTN NCSTN ADARB1 ADARB1 SPG11 SPG11 NES NES NFATC4 NFATC4 AARS AARS GPX1 GPX1 ATM ATM THRB THRB ROCK1 ROCK1 GBA GBA KRAS KRAS APP APP TNFRSF21 TNFRSF21 ATN1 ATN1 NF1 NF1 NLRP1 NLRP1 TMTC4 TMTC4 SYNGAP1 SYNGAP1 DNAJC5B DNAJC5B CIT CIT GRIK2 GRIK2 OXR1 OXR1 FAIM2 FAIM2 HIPK2 HIPK2 PSEN1 PSEN1 PPARGC1A PPARGC1A APAF1 APAF1 ERBB3 ERBB3 FAM162A FAM162A BARHL1 BARHL1 RHOA RHOA FGF8 FGF8 LOC113891742 LOC113891742 STXBP1 STXBP1 POU4F3 POU4F3 SNCA SNCA NAE1 NAE1 GAPDH GAPDH ADNP ADNP CLN8 CLN8 TP63 TP63 HRAS HRAS HIF1A HIF1A NTRK1 NTRK1 DIABLO DIABLO RB1 RB1 NR4A2 NR4A2 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A4W2CRB3BRCT domain-containing protein. (169 aa)
EPHA7EPH receptor A7. (998 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
TFAP2BTranscription factor AP-2 beta. (488 aa)
A0A4W2BZH9Uncharacterized protein. (727 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (320 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
FASFas cell surface death receptor. (323 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (209 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis class T. (578 aa)
RAPSNReceptor associated protein of the synapse. (427 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa)
AXLAXL receptor tyrosine kinase. (878 aa)
TYRO3TYRO3 protein tyrosine kinase. (889 aa)
POU4F1POU domain protein. (421 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (218 aa)
ATF2Activating transcription factor 2. (447 aa)
DLX1Distal-less homeobox 1. (255 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (555 aa)
NCSTNNicastrin. (773 aa)
ADARB1Adenosine deaminase RNA specific B1. (740 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2428 aa)
NESNestin; Belongs to the intermediate filament family. (1798 aa)
NFATC4Nuclear factor of activated T cells 4. (979 aa)
AARSAlanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1001 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
THRBThyroid hormone receptor beta. (476 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
GBAGlucosylceramidase. (536 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
APPAmyloid beta precursor protein. (770 aa)
TNFRSF21TNF receptor superfamily member 21. (652 aa)
ATN1Atrophin 1. (1226 aa)
NF1Neurofibromin 1. (3024 aa)
NLRP1NLR family pyrin domain containing 1. (1410 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (828 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1300 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2068 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
OXR1Oxidation resistance 1. (925 aa)
FAIM2Fas apoptotic inhibitory molecule 2. (449 aa)
HIPK2Homeodomain interacting protein kinase 2. (1205 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
FAM162AFamily with sequence similarity 162 member A. (156 aa)
BARHL1BarH like homeobox 1. (327 aa)
RHOARas homolog family member A. (193 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
LOC113891742Uncharacterized protein; Belongs to the BI1 family. (301 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
POU4F3POU domain protein. (338 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (541 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ADNPActivity dependent neuroprotector homeobox. (1102 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (339 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
DIABLOUncharacterized protein. (238 aa)
RB1RB transcriptional corepressor 1. (928 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (609 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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