STRINGSTRING
INPP5K INPP5K PAK2 PAK2 GSN GSN ARHGEF18 ARHGEF18 CAPZB CAPZB SPTB SPTB SPTBN2 SPTBN2 CCDC84 CCDC84 VILL VILL CORO1A CORO1A MID1IP1 MID1IP1 CCNF CCNF A0A4W2BNB0 A0A4W2BNB0 A0A4W2BMR3 A0A4W2BMR3 NUBP1 NUBP1 DMTN DMTN SPEF1 SPEF1 NAV3 NAV3 PLEKHH1 PLEKHH1 CDK5RAP2 CDK5RAP2 BBS4 BBS4 WDR63 WDR63 PHLDB2 PHLDB2 TWF1 TWF1 FAM49B FAM49B PRKN PRKN MAPRE1 MAPRE1 TTBK2 TTBK2 KANK1 KANK1 TMEM67 TMEM67 CGNL1 CGNL1 CORO2A CORO2A PFN4 PFN4 TMOD4 TMOD4 VIL1 VIL1 PLEKHH2 PLEKHH2 MYADM MYADM CIB1 CIB1 ADD3 ADD3 CAPZA1 CAPZA1 TWF2 TWF2 ADD1 ADD1 PFN2 PFN2 TMOD1 TMOD1 SSH1 SSH1 CORO2B CORO2B CAPZA3 CAPZA3 STMN1 STMN1 CAV3 CAV3 LMOD2 LMOD2 LOC113879884 LOC113879884 RDX RDX MAP6D1 MAP6D1 SNCA SNCA LMOD1 LMOD1 F11R F11R STMN2 STMN2 HDGFL3 HDGFL3 SLIT2 SLIT2 TMOD2 TMOD2 ATXN7L2 ATXN7L2 GMFB GMFB WASF2 WASF2 KAT2B KAT2B TMEFF2 TMEFF2 DYRK1A DYRK1A TACSTD2 TACSTD2 EPS8 EPS8 SCIN SCIN APC2 APC2 A0A4W2EUZ6 A0A4W2EUZ6 TUBB4A TUBB4A KANK3 KANK3 CAMSAP3 CAMSAP3 LIMA1 LIMA1 MDM1 MDM1 ARAP1 ARAP1 TBCD TBCD FLII FLII MET MET CAPZA2 CAPZA2 A0A4W2EBL9 A0A4W2EBL9 AVIL AVIL TMOD3 TMOD3 SSH3 SSH3 GMFG GMFG CLIP3 CLIP3 ADD2 ADD2 FKBP4 FKBP4 RHPN2 RHPN2 KAT2A KAT2A CAMSAP2 CAMSAP2 CDH5 CDH5 SPTA1 SPTA1 TM6SF1 TM6SF1 ARHGEF2 ARHGEF2 ARHGAP28 ARHGAP28 FHOD3 FHOD3 CKAP2 CKAP2 CORO1B CORO1B SMAD4 SMAD4 ATXN7 ATXN7 PIK3CA PIK3CA A0A4W2DQB1 A0A4W2DQB1 PRKCD PRKCD ATXN7L1 ATXN7L1 TRIM37 TRIM37 WAS WAS KANK4 KANK4 TAOK1 TAOK1 LMOD3 LMOD3 RBM14 RBM14 DLC1 DLC1 DEF6 DEF6 PICK1 PICK1 RHPN1 RHPN1 LOC113884473 LOC113884473 SSH2 SSH2 ARPIN ARPIN GAS2L2 GAS2L2 PIK3R1 PIK3R1 KATNB1 KATNB1 APC APC TMSB4X TMSB4X A0A4W2CAT2 A0A4W2CAT2 CTNNA2 CTNNA2 MKKS MKKS TMSB10 TMSB10 CAMSAP1 CAMSAP1 BMERB1 BMERB1 HIP1R HIP1R CAPG CAPG SPTBN4 SPTBN4 SPTBN1 SPTBN1 EML2 EML2 ARFGEF1 ARFGEF1 SVIL SVIL SWAP70 SWAP70 SHANK1 SHANK1 MYOC MYOC A0A4W2CQU2 A0A4W2CQU2 LOC113879851 LOC113879851 SPTAN1 SPTAN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
GSNGelsolin. (846 aa)
ARHGEF18Uncharacterized protein. (1345 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (306 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2331 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2531 aa)
CCDC84Coiled-coil domain containing 84. (384 aa)
VILLVillin like. (856 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
MID1IP1MID1 interacting protein 1. (182 aa)
CCNFCyclin F; Belongs to the cyclin family. (479 aa)
A0A4W2BNB0Uncharacterized protein. (146 aa)
A0A4W2BMR3Rho-GAP domain-containing protein. (263 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (385 aa)
DMTNDematin actin binding protein. (467 aa)
SPEF1Sperm flagellar 1. (236 aa)
NAV3Neuron navigator 3. (2385 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1359 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1820 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
WDR63WD repeat domain 63. (892 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1343 aa)
TWF1Twinfilin actin binding protein 1. (368 aa)
FAM49BFamily with sequence similarity 49 member B. (465 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (295 aa)
TTBK2Tau tubulin kinase 2. (1243 aa)
KANK1KN motif and ankyrin repeat domains 1. (1384 aa)
TMEM67Transmembrane protein 67. (996 aa)
CGNL1Cingulin like 1. (1293 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (581 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
TMOD4Tropomodulin 4. (379 aa)
VIL1Villin 1. (827 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1491 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ADD3Adducin 3. (706 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
ADD1Adducin 1. (769 aa)
PFN2Profilin; Belongs to the profilin family. (142 aa)
TMOD1Tropomodulin 1. (359 aa)
SSH1Slingshot protein phosphatase 1. (988 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (503 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
STMN1Uncharacterized protein. (295 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LMOD2Leiomodin 2. (585 aa)
LOC113879884Uncharacterized protein. (317 aa)
RDXRadixin. (624 aa)
MAP6D1MAP6 domain containing 1. (192 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
LMOD1Leiomodin 1. (578 aa)
F11RF11 receptor. (298 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
HDGFL3HDGF like 3. (203 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
TMOD2Tropomodulin 2. (351 aa)
ATXN7L2Ataxin 7 like 2. (784 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
WASF2WASP family member 2. (493 aa)
KAT2BLysine acetyltransferase 2B. (990 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (429 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
TACSTD2Tumor associated calcium signal transducer 2. (319 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (836 aa)
SCINScinderin. (832 aa)
APC2APC regulator of WNT signaling pathway 2. (2264 aa)
A0A4W2EUZ6RING-type domain-containing protein. (58 aa)
TUBB4ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
KANK3KN motif and ankyrin repeat domains 3. (876 aa)
CAMSAP3CKK domain-containing protein. (171 aa)
LIMA1LIM domain and actin binding 1. (761 aa)
MDM1Mdm1 nuclear protein. (724 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1740 aa)
TBCDTubulin folding cofactor D. (1226 aa)
FLIIFLII actin remodeling protein. (1268 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
A0A4W2EBL9Uncharacterized protein. (1267 aa)
AVILAdvillin. (816 aa)
TMOD3Tropomodulin 3. (352 aa)
SSH3Slingshot protein phosphatase 3. (649 aa)
GMFGGlia maturation factor gamma. (182 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
ADD2Adducin 2. (724 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
RHPN2Rhophilin Rho GTPase binding protein 2. (686 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
CAMSAP2Calmodulin regulated spectrin associated protein family member 2. (1506 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2419 aa)
TM6SF1Transmembrane 6 superfamily member 1. (370 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1223 aa)
ARHGAP28Rho GTPase activating protein 28. (755 aa)
FHOD3Formin homology 2 domain containing 3. (1612 aa)
CKAP2Cytoskeleton associated protein 2. (674 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (488 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ATXN7SCA7 domain-containing protein. (886 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
A0A4W2DQB1Coronin; Belongs to the WD repeat coronin family. (262 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ATXN7L1Ataxin 7 like 1. (993 aa)
TRIM37Tripartite motif containing 37. (961 aa)
WASWASP actin nucleation promoting factor. (559 aa)
KANK4KN motif and ankyrin repeat domains 4. (1014 aa)
TAOK1TAO kinase 1. (1001 aa)
LMOD3Leiomodin 3. (567 aa)
RBM14RNA binding motif protein 14. (669 aa)
DLC1DLC1 Rho GTPase activating protein. (1169 aa)
DEF6DEF6 guanine nucleotide exchange factor. (701 aa)
PICK1Protein interacting with PRKCA 1. (464 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (729 aa)
LOC113884473CH_2 domain-containing protein. (271 aa)
SSH2Slingshot protein phosphatase 2. (1429 aa)
ARPINUncharacterized protein. (226 aa)
GAS2L2Growth arrest specific 2 like 2. (875 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (689 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
A0A4W2CAT2MARVEL domain-containing protein. (335 aa)
CTNNA2Catenin alpha 2. (953 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
CAMSAP1Calmodulin regulated spectrin associated protein 1. (1562 aa)
BMERB1BMERB domain containing 1. (232 aa)
HIP1RHuntingtin interacting protein 1 related. (1066 aa)
CAPGCapping actin protein, gelsolin like. (412 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2615 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2350 aa)
EML2HELP domain-containing protein. (370 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
SVILSupervillin. (2301 aa)
SWAP70Switching B cell complex subunit SWAP70. (585 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2179 aa)
MYOCMyocilin. (490 aa)
A0A4W2CQU2Uncharacterized protein. (315 aa)
LOC113879851Uncharacterized protein. (303 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2498 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (20%) [HD]