STRINGSTRING
RTN4 RTN4 TSC2 TSC2 A0A4W2BND6 A0A4W2BND6 TNFSF11 TNFSF11 DAG1 DAG1 HYAL2 HYAL2 PHLPP1 PHLPP1 STOX1 STOX1 GFRAL GFRAL SESN3 SESN3 PKHD1 PKHD1 MST1R MST1R DRD2 DRD2 PHB PHB CSF3 CSF3 ADAM8 ADAM8 RET RET PLEKHA1 PLEKHA1 PHLDA3 PHLDA3 SLC9A3R1 SLC9A3R1 A0A4W2C5I5 A0A4W2C5I5 TPBG TPBG EGFR EGFR FGFR1 FGFR1 RICTOR RICTOR NOP53 NOP53 TGFB1 TGFB1 A0A4W2CIL9 A0A4W2CIL9 ANGPT1 ANGPT1 TGFBR1 TGFBR1 STK3 STK3 XDH XDH DDIT3 DDIT3 MYOC MYOC FERMT2 FERMT2 PIK3CD PIK3CD MTOR MTOR GAS6 GAS6 CPNE1 CPNE1 CASS4 CASS4 GATA3 GATA3 LEP LEP TEK TEK FAM110A FAM110A HCLS1 HCLS1 AXL AXL FAM110D FAM110D F3 F3 DLG1 DLG1 CAVIN3 CAVIN3 OSBPL8 OSBPL8 FAM110C FAM110C THPO THPO A0A4W2D8G7 A0A4W2D8G7 RAPGEF1 RAPGEF1 HAX1 HAX1 INPP5K INPP5K PIK3CG PIK3CG PIK3CA PIK3CA GPX1 GPX1 A0A4W2DRC1 A0A4W2DRC1 NOX4 NOX4 A0A4W2DS38 A0A4W2DS38 SIRT1 SIRT1 MFHAS1 MFHAS1 GCNT2 GCNT2 LRP2 LRP2 OSM OSM IL18 IL18 PIK3CB PIK3CB GPER1 GPER1 PPARA PPARA SH2B3 SH2B3 SFRP5 SFRP5 C1QTNF1 C1QTNF1 MC1R MC1R CD28 CD28 DLG2 DLG2 CHI3L1 CHI3L1 ARRB2 ARRB2 PTPRJ PTPRJ RAMP3 RAMP3 F10 F10 ENG ENG FGF2 FGF2 ITGB1BP1 ITGB1BP1 MET MET TNF TNF THBS1 THBS1 MEIS3 MEIS3 MTDH MTDH F7 F7 NTS NTS HPSE HPSE OTUD3 OTUD3 MUL1 MUL1 GDF15 GDF15 EPHA2 EPHA2 C1QTNF6 C1QTNF6 BANK1 BANK1 IL26 IL26 BAG4 BAG4 MSTN MSTN FLCN FLCN SRC SRC LEMD2 LEMD2 C1QTNF12 C1QTNF12 RNF41 RNF41 TCF7L2 TCF7L2 NTRK2 NTRK2 ITGB1 ITGB1 NTRK3 NTRK3 CCL19 CCL19 KIF24-2 KIF24-2 PTEN PTEN FAM110B FAM110B MAZ MAZ CAV3 CAV3 RRAS RRAS RCN3 RCN3 PPP2CA PPP2CA MYDGF MYDGF NTRK1 NTRK1 HBEGF HBEGF CCL21 CCL21 CIB1 CIB1 CX3CR1 CX3CR1 IGF1R IGF1R INSR INSR STK11 STK11 SPRY2 SPRY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RTN4Reticulon. (1200 aa)
TSC2TSC complex subunit 2. (1887 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
DAG1Dystroglycan 1. (1096 aa)
HYAL2Hyaluronidase. (473 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1503 aa)
STOX1Storkhead box 1. (984 aa)
GFRALGDNF family receptor alpha like. (379 aa)
SESN3Sestrin 3. (492 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4060 aa)
MST1RMacrophage stimulating 1 receptor. (1401 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PHBProhibitin. (285 aa)
CSF3Colony stimulating factor 3. (215 aa)
ADAM8ADAM metallopeptidase domain 8. (772 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
PHLDA3Pleckstrin homology like domain family A member 3. (123 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (368 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
TPBGTrophoblast glycoprotein. (420 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
FGFR1Fibroblast growth factor receptor. (856 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1789 aa)
NOP53NOP53 ribosome biogenesis factor. (534 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
A0A4W2CIL9Uncharacterized protein. (423 aa)
ANGPT1Angiopoietin 1. (498 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
STK3Serine/threonine kinase 3. (491 aa)
XDHXanthine dehydrogenase. (1332 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
MYOCMyocilin. (490 aa)
FERMT2Fermitin family member 2. (706 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GAS6Growth arrest specific 6. (671 aa)
CPNE1Copine 1. (542 aa)
CASS4Cas scaffold protein family member 4. (811 aa)
GATA3GATA binding protein 3. (467 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
FAM110AFamily with sequence similarity 110 member A. (295 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (485 aa)
AXLAXL receptor tyrosine kinase. (878 aa)
FAM110DFamily with sequence similarity 110 member D. (304 aa)
F3Coagulation factor III, tissue factor. (370 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
CAVIN3Caveolae associated protein 3. (260 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (910 aa)
FAM110CFamily with sequence similarity 110 member C. (308 aa)
THPOThrombopoietin. (353 aa)
A0A4W2D8G7Uncharacterized protein. (65 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
HAX1HCLS1 associated protein X-1. (287 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (204 aa)
A0A4W2DRC1Uncharacterized protein. (166 aa)
NOX4NADPH oxidase 4. (578 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
SIRT1Sirtuin 1. (734 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
LRP2LDL receptor related protein 2. (4647 aa)
OSMOncostatin M. (235 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
SH2B3SH2B adaptor protein 3. (587 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
C1QTNF1C1q and TNF related 1. (279 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (317 aa)
CD28CD28 molecule. (265 aa)
DLG2Discs large MAGUK scaffold protein 2. (1009 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (473 aa)
ARRB2Arrestin beta 2. (409 aa)
PTPRJPeptidylprolyl isomerase. (1344 aa)
RAMP3Receptor activity modifying protein 3. (150 aa)
F10Coagulation factor X. (608 aa)
ENGEndoglin. (649 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
THBS1Thrombospondin 1. (1170 aa)
MEIS3Meis homeobox 3. (436 aa)
MTDHMetadherin. (613 aa)
F7Coagulation factor VII. (447 aa)
NTSNeurotensin. (170 aa)
HPSEHeparanase. (661 aa)
OTUD3OTU deubiquitinase 3. (397 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (350 aa)
GDF15Growth differentiation factor 15. (308 aa)
EPHA2EPH receptor A2. (1007 aa)
C1QTNF6C1q and TNF related 6. (269 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (781 aa)
IL26Interleukin 26. (171 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
MSTNMyostatin. (375 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
SRCTyrosine-protein kinase. (559 aa)
LEMD2LEM domain containing 2. (495 aa)
C1QTNF12C1q and TNF related 12. (299 aa)
RNF41Ring finger protein 41. (317 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
CCL19C-C motif chemokine. (115 aa)
KIF24-2Myogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (799 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FAM110BFamily with sequence similarity 110 member B. (569 aa)
MAZMYC associated zinc finger protein. (495 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RRASRAS related. (218 aa)
RCN3Reticulocalbin 3. (328 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MYDGFMyeloid derived growth factor. (174 aa)
NTRK1Tyrosine-protein kinase receptor. (821 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
CIB1Calcium and integrin binding 1. (191 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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