STRINGSTRING
KLHL3 KLHL3 ATP12A ATP12A CLN3 CLN3 A0A4W2BQI8 A0A4W2BQI8 RAB7A RAB7A SLC4A7 SLC4A7 BCL2 BCL2 UMOD UMOD RHAG RHAG TFAP2B TFAP2B A0A4W2BYF2 A0A4W2BYF2 UPK3A UPK3A ATP6V1E1 ATP6V1E1 SCNN1A SCNN1A WNK1 WNK1 RHCG RHCG ATP6V0D1 ATP6V0D1 SLC12A4 SLC12A4 SLC26A6 SLC26A6 SLC4A1 SLC4A1 TCIRG1 TCIRG1 ATP6V0A2 ATP6V0A2 A0A4W2CG29 A0A4W2CG29 IL1A IL1A ATP6V0A1 ATP6V0A1 SLC9A3 SLC9A3 CFTR CFTR SLC11A1 SLC11A1 SLC8A1 SLC8A1 SLC4A5 SLC4A5 SLC4A3 SLC4A3 MAPK1 MAPK1 EXT1 EXT1 ATP4B ATP4B RAB20 RAB20 ATP1B1 ATP1B1 SLC9A1 SLC9A1 LRRK2 LRRK2 SLC4A8 SLC4A8 EXT2 EXT2 SLC9A8 SLC9A8 KCNH2 KCNH2 LOC113878888 LOC113878888 SLC4A2 SLC4A2 GPR89A GPR89A SLC4A10 SLC4A10 PPT1 PPT1 TM9SF4 TM9SF4 SLC9A9 SLC9A9 SLC26A3 SLC26A3 ATP6V0C ATP6V0C KCNJ10 KCNJ10 AQP11 AQP11 ATP6V0E2 ATP6V0E2 ATP6AP1L ATP6AP1L TMEM199 TMEM199 KCNMA1 KCNMA1 SCNN1B SCNN1B TMEM9 TMEM9 SLC4A9 SLC4A9 PDK2 PDK2 SLC12A9 SLC12A9 A0A4W2E9C1 A0A4W2E9C1 SLC12A1 SLC12A1 ATP4A ATP4A GRN GRN SLC9A4 SLC9A4 SLC12A3 SLC12A3 UBE3A UBE3A EDNRB EDNRB ATP6V0D2 ATP6V0D2 CHP1 CHP1 ATP5F1B ATP5F1B DMXL2 DMXL2 SLC9A2 SLC9A2 ATP6V0A4 ATP6V0A4 SLC9C1 SLC9C1 SLC12A6 SLC12A6 SLC12A8 SLC12A8 TMEM175 TMEM175 CLN6 CLN6 SLC12A2 SLC12A2 DMXL1 DMXL1 TMEM165 TMEM165 SLC4A4 SLC4A4 ATP6V0B ATP6V0B RHBG RHBG TMPRSS3 TMPRSS3 SLC26A4 SLC26A4 ATP1B3 ATP1B3 SLC9A7 SLC9A7 EDNRA EDNRA ATP6V1B1 ATP6V1B1 SNAPIN SNAPIN SLC12A5 SLC12A5 ATP1A4 ATP1A4 ATP1A3 ATP1A3 ATP1A2 ATP1A2 SCNN1G SCNN1G ATP1A1 ATP1A1 CA7 CA7 KCNQ1 KCNQ1 SLC12A7 SLC12A7 CLIC4 CLIC4 CA2 CA2 CLN5 CLN5 SLC1A3 SLC1A3 MLLT6 MLLT6 ATP6V1C1 ATP6V1C1 RAB38 RAB38 PDK4 PDK4 ATP6V1A ATP6V1A ATP6AP2 ATP6AP2 OTC OTC SLC9A5 SLC9A5 RAB39A RAB39A ATP1B2 ATP1B2 MAPK3 MAPK3 EDN1 EDN1 ATP6V1B2 ATP6V1B2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLHL3Kelch like family member 3. (587 aa)
ATP12ASodium/potassium-transporting ATPase subunit alpha. (1017 aa)
CLN3Battenin. (460 aa)
A0A4W2BQI8Uncharacterized protein. (426 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
SLC4A7Anion exchange protein. (1241 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
UMODUromodulin. (643 aa)
RHAGRh associated glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (426 aa)
TFAP2BTranscription factor AP-2 beta. (488 aa)
A0A4W2BYF2Uncharacterized protein. (968 aa)
UPK3AReverse transcriptase domain-containing protein. (467 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (324 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (682 aa)
WNK1WNK lysine deficient protein kinase 1. (2386 aa)
RHCGRh family C glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (598 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
SLC12A4Solute carrier family 12 member 4. (1086 aa)
SLC26A6Solute carrier family 26 member 6. (763 aa)
SLC4A1Anion exchange protein. (1059 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (853 aa)
A0A4W2CG29Uncharacterized protein. (123 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (835 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
SLC11A1Solute carrier family 11 member 1. (601 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SLC4A5Anion exchange protein. (1142 aa)
SLC4A3Anion exchange protein. (1226 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
RAB20RAB20, member RAS oncogene family. (231 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (818 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SLC4A8Anion exchange protein. (1092 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
SLC9A8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (597 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1161 aa)
LOC113878888Ammonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (417 aa)
SLC4A2Anion exchange protein. (1276 aa)
GPR89AUncharacterized protein. (544 aa)
SLC4A10Anion exchange protein. (1147 aa)
PPT1Uncharacterized protein. (336 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (640 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (256 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6AP1LUncharacterized protein. (381 aa)
TMEM199Transmembrane protein 199. (268 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1276 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (736 aa)
TMEM9Transmembrane protein 9. (181 aa)
SLC4A9Anion exchange protein. (957 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SLC12A9Solute carrier family 12 member 9. (914 aa)
A0A4W2E9C1Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
SLC12A1Solute carrier family 12 member 1. (1099 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1034 aa)
GRNGranulin precursor. (663 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (797 aa)
SLC12A3Solute carrier family 12 member 3. (1030 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (441 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
DMXL2Dmx like 2. (3036 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
SLC9C1Solute carrier family 9 member C1. (1145 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
SLC12A8Solute carrier family 12 member 8. (686 aa)
TMEM175Transmembrane protein 175. (585 aa)
CLN6CLN6 transmembrane ER protein. (380 aa)
SLC12A2Solute carrier family 12 member 2. (1204 aa)
DMXL1Dmx like 1. (3083 aa)
TMEM165GDT1 family protein. (324 aa)
SLC4A4Anion exchange protein. (1190 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
RHBGRh family B glycoprotein (gene/pseudogene); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (455 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (454 aa)
SLC26A4Solute carrier family 26 member 4. (1025 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (731 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SLC12A5Solute carrier family 12 member 5. (1144 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (670 aa)
SLC12A7Solute carrier family 12 member 7. (1091 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
CLN5Uncharacterized protein. (358 aa)
SLC1A3Amino acid transporter. (542 aa)
MLLT6MLLT6, PHD finger containing. (1095 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
ATP6AP2Uncharacterized protein. (377 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (900 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
EDN1Endothelin 1. (202 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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