STRINGSTRING
MSX1 MSX1 SOX9 SOX9 MEF2C MEF2C A0A4W2I4T2 A0A4W2I4T2 IGF1 IGF1 WNT1 WNT1 TP53 TP53 MEF2D MEF2D NOTUM NOTUM GJA1 GJA1 SBDS SBDS RARB RARB PEX7 PEX7 PTPN11 PTPN11 PITX2 PITX2 SMPD3 SMPD3 FGF4 FGF4 ATG9A ATG9A VPS33B VPS33B SH3PXD2B SH3PXD2B SNX10 SNX10 NPPC NPPC MMP13 MMP13 CCDC154 CCDC154 TFAP2A TFAP2A BMP6 BMP6 LTBP3 LTBP3 LTF LTF TNFSF11 TNFSF11 EBP EBP GLG1 GLG1 COL13A1 COL13A1 RARA RARA RUNX2 RUNX2 MAPK11 MAPK11 EP300 EP300 HOXB4 HOXB4 PHOSPHO1 PHOSPHO1 SCX SCX CHAD CHAD FLI1 FLI1 VKORC1 VKORC1 PAPSS2 PAPSS2 GP9 GP9 SPNS2 SPNS2 CTC1 CTC1 MMP16 MMP16 SLC38A10 SLC38A10 CSGALNACT1 CSGALNACT1 ACTN3 ACTN3 ADAMTS12 ADAMTS12 FAT4 FAT4 MEGF8 MEGF8 SLC10A7 SLC10A7 AXIN2 AXIN2 SRF SRF SCUBE2 SCUBE2 PIP4K2A PIP4K2A A0A4W2CLZ8 A0A4W2CLZ8 HOXA11 HOXA11 NPR2 NPR2 TRPV4 TRPV4 PTPN6 PTPN6 EXT1 EXT1 MYOC MYOC IHH IHH SULF2 SULF2 LRRK1 LRRK1 SDC3 SDC3 FGF18 FGF18 CITED2 CITED2 DHRS3 DHRS3 GLI3 GLI3 BNC2 BNC2 PPIB PPIB GNAS GNAS LEP LEP SERPINH1 SERPINH1 CER1 CER1 ZNF385A ZNF385A NSD2 NSD2 MMP14 MMP14 TMEM38B TMEM38B DCHS1 DCHS1 A0A4W2D3H6 A0A4W2D3H6 TTC9 TTC9 RARG RARG OGN OGN TRIM45 TRIM45 PAX1 PAX1 EXT2 EXT2 ATF2 ATF2 THPO THPO EPYC EPYC SP5 SP5 EVC EVC INSIG1 INSIG1 COMP COMP ECM1 ECM1 ASXL1 ASXL1 KIT KIT ZMPSTE24 ZMPSTE24 ALPL ALPL LEPR LEPR TIFAB TIFAB INSIG2 INSIG2 TWIST1 TWIST1 TBXT TBXT TAL1 TAL1 THBS3 THBS3 BMPR1B BMPR1B FOXP1 FOXP1 DDR2 DDR2 OSTN OSTN IFITM5 IFITM5 LRP5 LRP5 RAB23 RAB23 MED1 MED1 SMAD1 SMAD1 PLXNB1 PLXNB1 TMEM107 TMEM107 ZFPM1 ZFPM1 GPR68 GPR68 SH2B3 SH2B3 MEIS1 MEIS1 CCN4 CCN4 TMEM119 TMEM119 MAP2K6 MAP2K6 SULF1 SULF1 TRIP11 TRIP11 TGFBR2 TGFBR2 INPPL1 INPPL1 PDGFC PDGFC RANBP3L RANBP3L MATN1 MATN1 IMPAD1 IMPAD1 ABI1 ABI1 FREM1 FREM1 PTPRC PTPRC TULP3 TULP3 CYP26B1 CYP26B1 BMP4 BMP4 PAPPA2 PAPPA2 COL2A1 COL2A1 TGM2 TGM2 P3H1 P3H1 DLX5 DLX5 NEUROG1 NEUROG1 ITGB6 ITGB6 BGLAP BGLAP CDX1 CDX1 CBS CBS ANXA6 ANXA6 A0A4W2F2V6 A0A4W2F2V6 LRRC17 LRRC17 BBX BBX COL3A1 COL3A1 SFRP4 SFRP4 COL1A1 COL1A1 WASF2 WASF2 OSR2 OSR2 RHOA RHOA SMAD5 SMAD5 SHOX2 SHOX2 SRC SRC PAFAH1B1 PAFAH1B1 FGF8 FGF8 IFT80 IFT80 NAB2 NAB2 MIGA2 MIGA2 BMP2 BMP2 SEMA4D SEMA4D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSX1Msh homeobox 1. (366 aa)
SOX9SRY-box transcription factor 9. (524 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
A0A4W2I4T2Uncharacterized protein. (74 aa)
IGF1Insulin like growth factor 1. (188 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
MEF2DMyocyte enhancer factor 2D. (514 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (499 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
RARBRetinoic acid receptor beta. (456 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
PITX2Homeobox protein. (325 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ATG9AUncharacterized protein. (1498 aa)
VPS33BUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
SH3PXD2BSH3 and PX domains 2B. (956 aa)
SNX10Sorting nexin 10. (200 aa)
NPPCNatriuretic peptide C. (193 aa)
MMP13Matrix metallopeptidase 13. (471 aa)
CCDC154Coiled-coil domain containing 154. (526 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
BMP6Bone morphogenetic protein 6. (525 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1341 aa)
LTFLactotransferrin; Belongs to the transferrin family. (726 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
EBPEXPERA domain-containing protein. (230 aa)
GLG1Golgi glycoprotein 1. (1206 aa)
COL13A1Collagen type XIII alpha 1 chain. (751 aa)
RARARetinoic acid receptor alpha. (477 aa)
RUNX2RUNX family transcription factor 2. (527 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
EP300E1A binding protein p300. (2411 aa)
HOXB4Homeobox B4. (251 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (334 aa)
SCXScleraxis bHLH transcription factor. (202 aa)
CHADChondroadherin. (361 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (464 aa)
VKORC1VKc domain-containing protein. (92 aa)
PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2. (620 aa)
GP9Glycoprotein IX platelet. (175 aa)
SPNS2Sphingolipid transporter 2. (549 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
SLC38A10Solute carrier family 38 member 10. (1089 aa)
CSGALNACT1Hexosyltransferase. (526 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (901 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1607 aa)
FAT4FAT atypical cadherin 4. (4982 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (359 aa)
AXIN2Axin 2. (836 aa)
SRFSerum response factor. (509 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1027 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (405 aa)
A0A4W2CLZ8Fork-head domain-containing protein. (225 aa)
HOXA11Homeobox A11. (316 aa)
NPR2Guanylate cyclase. (1041 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (803 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
MYOCMyocilin. (490 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
SULF2Sulfatase 2. (865 aa)
LRRK1Leucine rich repeat kinase 1. (2107 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (603 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
GLI3GLI family zinc finger 3. (1587 aa)
BNC2Basonuclin 2. (1107 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GNASGNAS complex locus. (1004 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (418 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
ZNF385AZinc finger protein 385A. (393 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
DCHS1Dachsous cadherin-related 1. (3525 aa)
A0A4W2D3H6Fork-head domain-containing protein. (457 aa)
TTC9Tetratricopeptide repeat domain 9. (230 aa)
RARGRetinoic acid receptor gamma. (519 aa)
OGNOsteoglycin. (308 aa)
TRIM45Tripartite motif containing 45. (625 aa)
PAX1Paired box 1. (593 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
ATF2Activating transcription factor 2. (447 aa)
THPOThrombopoietin. (353 aa)
EPYCEpiphycan. (321 aa)
SP5Sp5 transcription factor. (397 aa)
EVCEvC ciliary complex subunit 1. (1032 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (299 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ECM1Extracellular matrix protein 1. (574 aa)
ASXL1ASXL transcriptional regulator 1. (1535 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ALPLAlkaline phosphatase. (524 aa)
LEPRLeptin receptor. (1165 aa)
TIFABTIFA inhibitor. (222 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (266 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
TBXTT-box transcription factor T. (435 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
THBS3Thrombospondin 3. (998 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
FOXP1Fork-head domain-containing protein. (691 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (869 aa)
OSTNOsteocrin. (132 aa)
IFITM5Interferon induced transmembrane protein 5. (134 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1629 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PLXNB1Plexin B1. (2155 aa)
TMEM107Transmembrane protein 107. (140 aa)
ZFPM1Zinc finger protein, FOG family member 1. (984 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (383 aa)
SH2B3SH2B adaptor protein 3. (587 aa)
MEIS1Meis homeobox 1. (492 aa)
CCN4Cellular communication network factor 4. (368 aa)
TMEM119Transmembrane protein 119. (287 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
SULF1Sulfatase 1. (1109 aa)
TRIP11Thyroid hormone receptor interactor 11. (1976 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
RANBP3LRAN binding protein 3 like. (466 aa)
MATN1Matrilin 1. (456 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
ABI1Abl interactor 1. (508 aa)
FREM1FRAS1 related extracellular matrix 1. (2180 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1243 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (482 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PAPPA2Pappalysin 2. (1791 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
TGM2Transglutaminase 2. (687 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
DLX5Distal-less homeobox 5. (289 aa)
NEUROG1Neurogenin 1. (247 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
CDX1Caudal type homeobox 1. (265 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
ANXA6Annexin. (751 aa)
A0A4W2F2V6Uncharacterized protein. (122 aa)
LRRC17Arm_2 domain-containing protein. (572 aa)
BBXBBX high mobility group box domain containing. (942 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
COL1A1Collagen type I alpha 1 chain. (1584 aa)
WASF2WASP family member 2. (493 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
RHOARas homolog family member A. (193 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SHOX2Short stature homeobox 2. (331 aa)
SRCTyrosine-protein kinase. (559 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
IFT80Intraflagellar transport 80. (781 aa)
NAB2NGFI-A binding protein 2. (525 aa)
MIGA2Mitoguardin 2. (593 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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