(20 nodes) Response to growth hormone network (Bos indicus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Others

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protein homology

Your Input:
	JAK2	Tyrosine-protein kinase. (1132 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	SOCS2	Suppressor of cytokine signaling 2. (202 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	TYK2	Tyrosine-protein kinase. (1187 aa)
	LOC113894643	Uncharacterized protein. (222 aa)
	GHR	Growth hormone receptor. (657 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (271 aa)
	A0A4W2EWY4	Uncharacterized protein. (214 aa)
	JAK3	Tyrosine-protein kinase. (1181 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	JAK1	Tyrosine-protein kinase. (1110 aa)
	TRIM16	Uncharacterized protein. (562 aa)
	IGF1	Insulin like growth factor 1. (188 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	A0A4W2C9G4	Uncharacterized protein. (232 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	A0A4W2C9G4	A0A4W2BND6	A0A4W2C9G4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.420
A0A4W2BND6	AKT1	A0A4W2BND6	A0A4W2FNQ0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.554
A0A4W2BND6	GHR	A0A4W2BND6	A0A4W2E824	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth hormone receptor.	0.463
A0A4W2BND6	IGF1	A0A4W2BND6	A0A4W2I474	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.913
A0A4W2BND6	IGFBP5	A0A4W2BND6	A0A4W2EEX9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor binding protein 5.	0.422
A0A4W2BND6	JAK2	A0A4W2BND6	A0A4W2I4Q1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase.	0.464
A0A4W2BND6	STAT3	A0A4W2BND6	A0A4W2E9W2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.496
A0A4W2C5I5	A0A4W2C9G4	A0A4W2C5I5	A0A4W2C9G4	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.420
A0A4W2C5I5	AKT1	A0A4W2C5I5	A0A4W2FNQ0	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.554
A0A4W2C5I5	GHR	A0A4W2C5I5	A0A4W2E824	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth hormone receptor.	0.463
A0A4W2C5I5	IGF1	A0A4W2C5I5	A0A4W2I474	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.951
A0A4W2C5I5	IGFBP5	A0A4W2C5I5	A0A4W2EEX9	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor binding protein 5.	0.422
A0A4W2C5I5	JAK2	A0A4W2C5I5	A0A4W2I4Q1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase.	0.551
A0A4W2C5I5	STAT3	A0A4W2C5I5	A0A4W2E9W2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Signal transducer and activator of transcription.	0.496
A0A4W2C9G4	A0A4W2BND6	A0A4W2C9G4	A0A4W2BND6	Uncharacterized protein.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A4W2C9G4	A0A4W2C5I5	A0A4W2C9G4	A0A4W2C5I5	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A4W2C9G4	A0A4W2EWY4	A0A4W2C9G4	A0A4W2EWY4	Uncharacterized protein.	Uncharacterized protein.	0.569
A0A4W2C9G4	GHR	A0A4W2C9G4	A0A4W2E824	Uncharacterized protein.	Growth hormone receptor.	0.987
A0A4W2C9G4	IGF1	A0A4W2C9G4	A0A4W2I474	Uncharacterized protein.	Insulin like growth factor 1.	0.597
A0A4W2C9G4	JAK1	A0A4W2C9G4	A0A4W2GNE8	Uncharacterized protein.	Tyrosine-protein kinase.	0.815

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