STRINGSTRING
HRAS HRAS OAZ3 OAZ3 FBXW7 FBXW7 PRKD1 PRKD1 TRIM28 TRIM28 BBC3 BBC3 SMO SMO TOMM7-2 TOMM7-2 CTDSPL2 CTDSPL2 HCLS1 HCLS1 A0A4W2HBP3 A0A4W2HBP3 TMEM30A TMEM30A PRKAA1 PRKAA1 MIEF2 MIEF2 MFF MFF PRKACA PRKACA SAR1A SAR1A TCF7L2 TCF7L2 PIK3R2 PIK3R2 PCM1 PCM1 B3GAT3 B3GAT3 GSK3B GSK3B LEP LEP KCNB1 KCNB1 PDCD10 PDCD10 SFN SFN GLI3 GLI3 GAS6 GAS6 MAVS MAVS OAZ2 OAZ2 CDH1 CDH1 SAR1B SAR1B PLK3 PLK3 A0A4W2F3Y4 A0A4W2F3Y4 FBXW9 FBXW9 EFCAB7 EFCAB7 HDAC3 HDAC3 C2CD5 C2CD5 SHH SHH AKAP5 AKAP5 PPM1A PPM1A PSEN1 PSEN1 EDEM2 EDEM2 PRR5L PRR5L CHP1 CHP1 FYN FYN JUP JUP EDEM1 EDEM1 SLC35D3 SLC35D3 XPO4 XPO4 YWHAE YWHAE ERGIC3 ERGIC3 UBR5 UBR5 IPO5 IPO5 IFNG IFNG TARDBP TARDBP ICE1 ICE1 ITGB1BP1 ITGB1BP1 ANP32B ANP32B SEC16B SEC16B CEP131 CEP131 GSK3A GSK3A A0A4W2E2B7 A0A4W2E2B7 RBM22 RBM22 TPR TPR TGFB1 TGFB1 AKT2 AKT2 RIPOR1 RIPOR1 ZFAND1 ZFAND1 PIK3R1 PIK3R1 BAG3 BAG3 CEMIP CEMIP MYO1C MYO1C SIRT6 SIRT6 DMAP1 DMAP1 TM9SF4 TM9SF4 ERBB2 ERBB2 SORL1 SORL1 MIEF1 MIEF1 PRKCD PRKCD SLC51B SLC51B A0A4W2DP37 A0A4W2DP37 TCAF1 TCAF1 ECT2 ECT2 ZC3H12A ZC3H12A CDK5 CDK5 ZPR1 ZPR1 PDZK1 PDZK1 TMEM30B TMEM30B CD81 CD81 CAMK1 CAMK1 CHP2 CHP2 HYAL2 HYAL2 HSPA1L HSPA1L CIB1 CIB1 PTPN22 PTPN22 OAZ1 OAZ1 RAPGEF3 RAPGEF3 TOMM7 TOMM7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HRASHRas proto-oncogene, GTPase. (189 aa)
OAZ3Ornithine decarboxylase antizyme 3. (240 aa)
FBXW7F-box and WD repeat domain containing 7. (706 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
TRIM28Tripartite motif containing 28. (838 aa)
BBC3Uncharacterized protein. (193 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
TOMM7-2Uncharacterized protein. (55 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (485 aa)
A0A4W2HBP3CARD_2 domain-containing protein. (65 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (400 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MIEF2Mitochondrial elongation factor 2. (454 aa)
MFFMitochondrial fission factor. (409 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
PIK3R2Uncharacterized protein. (724 aa)
PCM1Pericentriolar material 1. (2220 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
PDCD10Programmed cell death 10. (212 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
GLI3GLI family zinc finger 3. (1587 aa)
GAS6Growth arrest specific 6. (671 aa)
MAVSMitochondrial antiviral signaling protein. (615 aa)
OAZ2Ornithine decarboxylase antizyme 2. (177 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
A0A4W2F3Y4Uncharacterized protein. (92 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
C2CD5C2 calcium dependent domain containing 5. (1137 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
AKAP5A-kinase anchoring protein 5. (428 aa)
PPM1APPM-type phosphatase domain-containing protein. (454 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
PRR5LProline rich 5 like. (644 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
FYNTyrosine-protein kinase. (537 aa)
JUPJunction plakoglobin. (745 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (658 aa)
SLC35D3Solute carrier family 35 member D3. (423 aa)
XPO4Exportin 4. (1152 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (268 aa)
ERGIC3ERGIC and golgi 3. (394 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2798 aa)
IPO5Importin 5. (1097 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TARDBPTAR DNA binding protein. (414 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2172 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (269 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1054 aa)
CEP131Centrosomal protein 131. (1154 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
A0A4W2E2B7Uncharacterized protein. (192 aa)
RBM22RNA binding motif protein 22. (420 aa)
TPRTranslocated promoter region, nuclear basket protein. (2444 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1330 aa)
ZFAND1Zinc finger AN1-type containing 1. (268 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BAG3BCL2 associated athanogene 3. (585 aa)
CEMIPCell migration inducing hyaluronidase 1. (1416 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
SIRT6Sirtuin 6. (391 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (513 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
SORL1Sortilin related receptor 1. (2211 aa)
MIEF1Mitochondrial elongation factor 1. (463 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SLC51BSolute carrier family 51 beta subunit. (130 aa)
A0A4W2DP37Uncharacterized protein. (114 aa)
TCAF1TRPM8 channel associated factor 1. (921 aa)
ECT2Epithelial cell transforming 2. (944 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (583 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ZPR1ZPR1 zinc finger. (459 aa)
PDZK1PDZ domain containing 1. (732 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (353 aa)
CD81Tetraspanin. (236 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (369 aa)
CHP2Calcineurin like EF-hand protein 2. (258 aa)
HYAL2Hyaluronidase. (473 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
CIB1Calcium and integrin binding 1. (191 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (808 aa)
OAZ1Ornithine decarboxylase antizyme 1. (225 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
TOMM7Uncharacterized protein. (59 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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