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| | PARP3 | Poly [ADP-ribose] polymerase. (515 aa) |
| | A0A4W2BP37 | Uncharacterized protein. (74 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (932 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1506 aa) |
| | PAXX | PAXX non-homologous end joining factor. (224 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (780 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (790 aa) |
| | PHF1 | PHD finger protein 1. (603 aa) |
| | TRAIP | TRAF interacting protein. (472 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1167 aa) |
| | ARPC1A | WD_REPEATS_REGION domain-containing protein. (430 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1375 aa) |
| | ARPC4 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (627 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (540 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa) |
| | WDR70 | WD repeat domain 70. (652 aa) |
| | UFL1 | UFM1 specific ligase 1. (792 aa) |
| | CNTD1 | Cyclin N-terminal domain containing 1. (328 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (813 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa) |
| | A0A4W2CSP1 | Uncharacterized protein. (319 aa) |
| | RPA2 | RPA_C domain-containing protein. (270 aa) |
| | SMC5 | SMC_N domain-containing protein. (1197 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (608 aa) |
| | A0A4W2CWS1 | RPA_C domain-containing protein. (253 aa) |
| | A0A4W2CX26 | Uncharacterized protein. (284 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (577 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | SHLD2 | Shieldin complex subunit 2. (962 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1544 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1175 aa) |
| | A0A4W2D2X3 | Zinc-hook domain-containing protein. (1440 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | CBX5 | Chromobox 5. (191 aa) |
| | ATF2 | Activating transcription factor 2. (447 aa) |
| | NKX3-1 | NK3 homeobox 1. (239 aa) |
| | A0A4W2DA03 | Uncharacterized protein; Belongs to the actin family. (416 aa) |
| | POLK | DNA polymerase kappa. (911 aa) |
| | SMARCAD1 | Uncharacterized protein. (1029 aa) |
| | ACTR3 | Uncharacterized protein; Belongs to the actin family. (418 aa) |
| | A0A4W2DHA5 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (159 aa) |
| | A0A4W2DJN4 | Uncharacterized protein; Belongs to the actin family. (356 aa) |
| | SIRT6 | Sirtuin 6. (391 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (567 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (501 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2171 aa) |
| | WAS | WASP actin nucleation promoting factor. (559 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (859 aa) |
| | POLH | DNA polymerase eta. (711 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) |
| | A0A4W2DY12 | RPA_C domain-containing protein. (270 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1966 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | C17orf53 | Chromosome 17 open reading frame 53. (654 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (513 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (816 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1098 aa) |
| | ARPC2 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | SIRT7 | Sirtuin 7. (420 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (190 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (550 aa) |
| | A0A4W2EMP6 | Uncharacterized protein. (232 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (610 aa) |
| | REC114 | REC114 meiotic recombination protein. (255 aa) |
| | HELQ | Helicase, POLQ like. (1092 aa) |
| | A0A4W2EVH0 | Uncharacterized protein. (420 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2465 aa) |
| | UBQLN4 | Ubiquilin 4. (734 aa) |
| | LMNA | Lamin A/C; Belongs to the intermediate filament family. (664 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (333 aa) |
| | A0A4W2F3C1 | RPA_C domain-containing protein. (250 aa) |
| | A0A4W2F400 | Uncharacterized protein. (410 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | APLF | Aprataxin and PNKP like factor. (509 aa) |
| | INTS3 | Integrator complex subunit 3. (1040 aa) |
| | OARD1 | O-acyl-ADP-ribose deacylase 1. (152 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | TIMELESS | Timeless circadian regulator. (1213 aa) |
| | CBX3 | Uncharacterized protein. (183 aa) |
| | ARPC5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (357 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | HELB | DNA helicase B. (1136 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (426 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa) |
