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RB1 RB1 CTNNB1 CTNNB1 SMAD2 SMAD2 A0A4W2C164 A0A4W2C164 KCNA1 KCNA1 HSP90AA1 HSP90AA1 NCOA3 NCOA3 HSPA2 HSPA2 SMTNL1 SMTNL1 EZR EZR A0A4W2CZ95 A0A4W2CZ95 GAPDH GAPDH RRM1 RRM1 TEAD2 TEAD2 LAP3 LAP3 TP53 TP53 NUMA1 NUMA1 DFFB DFFB FN1 FN1 KEAP1 KEAP1 AP2A2 AP2A2 CLTC CLTC A0A4W2DED5 A0A4W2DED5 FYN FYN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RB1RB transcriptional corepressor 1. (928 aa)
CTNNB1Catenin beta 1. (774 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
A0A4W2C164Uncharacterized protein; Belongs to the heat shock protein 70 family. (715 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (774 aa)
NCOA3Nuclear receptor coactivator. (1411 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
SMTNL1Smoothelin like 1. (471 aa)
EZREzrin. (638 aa)
A0A4W2CZ95Uncharacterized protein. (506 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
LAP3Leucine aminopeptidase 3. (519 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2123 aa)
DFFBDNA fragmentation factor subunit beta. (341 aa)
FN1Fibronectin 1. (2601 aa)
KEAP1Kelch like ECH associated protein 1. (623 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (935 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
A0A4W2DED5Uncharacterized protein; Belongs to the tropomyosin family. (320 aa)
FYNTyrosine-protein kinase. (537 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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