STRINGSTRING
PLEKHM1 PLEKHM1 ARF6 ARF6 ATG5 ATG5 ARAP1 ARAP1 DYNC2LI1 DYNC2LI1 ANLN ANLN ODF2L ODF2L A0A4W2ENV8 A0A4W2ENV8 NCKAP1 NCKAP1 FXR1 FXR1 CEP120 CEP120 PLD1 PLD1 RAB17 RAB17 CLRN1 CLRN1 RAP1GAP RAP1GAP RCC2 RCC2 EPS8 EPS8 CROCC CROCC EPHA2 EPHA2 TACSTD2 TACSTD2 RAC2 RAC2 CYFIP1 CYFIP1 RAB5A RAB5A CEP97 CEP97 CCDC151 CCDC151 MYO10 MYO10 KLF5 KLF5 TBC1D30 TBC1D30 WASF2 WASF2 MSTN MSTN ABITRAM ABITRAM NEURL1 NEURL1 EPS8L3 EPS8L3 ODF2 ODF2 SAXO2 SAXO2 SLIT2 SLIT2 FSCN1 FSCN1 ARHGAP24 ARHGAP24 RDX RDX CCL19 CCL19 SH3YL1 SH3YL1 ARHGAP35 ARHGAP35 BIN3 BIN3 CDC42EP3 CDC42EP3 AKIRIN1 AKIRIN1 BRK1 BRK1 MAK MAK HRAS HRAS FUZ FUZ PLEK2 PLEK2 ABI3 ABI3 PFN2 PFN2 EVI5L EVI5L CDK10 CDK10 TWF2 TWF2 ZMYND10 ZMYND10 FAM98C FAM98C CCL21 CCL21 WNT1 WNT1 FXR2 FXR2 EPS8L1 EPS8L1 KCTD17 KCTD17 CDC42EP5 CDC42EP5 RHOG RHOG A0A4W2ILH9 A0A4W2ILH9 PPP1R35 PPP1R35 IFT140 IFT140 AUTS2 AUTS2 IFT88 IFT88 CLN3 CLN3 RABEP2 RABEP2 VDAC3 VDAC3 ATMIN ATMIN A0A4W2BVZ1 A0A4W2BVZ1 CCP110 CCP110 MIEN1 MIEN1 YAP1 YAP1 TBC1D7 TBC1D7 CDC42EP1 CDC42EP1 LIMK2 LIMK2 DEF8 DEF8 SEPTIN9 SEPTIN9 NDEL1 NDEL1 PIK3R1 PIK3R1 APC APC ENTR1 ENTR1 ATP8B1 ATP8B1 A0A4W2CDP2 A0A4W2CDP2 CCDC88A CCDC88A MARK4 MARK4 PLCE1 PLCE1 CAV1 CAV1 SRF SRF MYO3A MYO3A GDI2 GDI2 TGFBR1 TGFBR1 RIPOR2 RIPOR2 CNTROB CNTROB EVL EVL SDCCAG8 SDCCAG8 DZIP1 DZIP1 MTOR MTOR KANK1 KANK1 SAXO1 SAXO1 TWF1 TWF1 C15orf62 C15orf62 FER FER ATG3 ATG3 HTT HTT BBS4 BBS4 FNBP1L FNBP1L SYNE2 SYNE2 KIF24 KIF24 CROCC2 CROCC2 TAPT1 TAPT1 DMTN DMTN MYO3B MYO3B A0A4W2DA03 A0A4W2DA03 DPYSL3 DPYSL3 CDC42 CDC42 ACTR3 ACTR3 CAPZB CAPZB GAP43 GAP43 TRPM2 TRPM2 A0A4W2DJN4 A0A4W2DJN4 EPS8L2 EPS8L2 FETUB FETUB WAS WAS PRKCD PRKCD PIK3CA PIK3CA STAP1 STAP1 PALM PALM CEP135 CEP135 MAPK15 MAPK15 DCDC2 DCDC2 A0A4W2DYK7 A0A4W2DYK7 CYLD CYLD GPM6A GPM6A P2RX7 P2RX7 DAAM2 DAAM2 WDPCP WDPCP CENPJ CENPJ NRP1 NRP1 RHOQ RHOQ IFT20 IFT20 CORO1C CORO1C CDC42EP4 CDC42EP4 FAM98A FAM98A MCIDAS MCIDAS MPHOSPH9 MPHOSPH9 TESK1 TESK1 RALA RALA HAP1 HAP1 A0A4W2EE88 A0A4W2EE88 RP1 RP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1062 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (214 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1740 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (352 aa)
ANLNAnillin actin binding protein. (1129 aa)
ODF2LOuter dense fiber of sperm tails 2 like. (603 aa)
A0A4W2ENV8Tcp10_C domain-containing protein. (234 aa)
NCKAP1NCK associated protein 1. (1139 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
CEP120Centrosomal protein 120. (993 aa)
PLD1Phospholipase. (1126 aa)
RAB17RAB17, member RAS oncogene family. (233 aa)
CLRN1Clarin 1. (232 aa)
RAP1GAPRAP1 GTPase activating protein. (1040 aa)
RCC2Regulator of chromosome condensation 2. (520 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (836 aa)
CROCCCiliary rootlet coiled-coil, rootletin. (2071 aa)
EPHA2EPH receptor A2. (1007 aa)
TACSTD2Tumor associated calcium signal transducer 2. (319 aa)
RAC2Rac family small GTPase 2. (209 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
RAB5AUncharacterized protein. (215 aa)
CEP97Centrosomal protein 97. (858 aa)
CCDC151Coiled-coil domain containing 151. (621 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
KLF5Kruppel like factor 5. (454 aa)
TBC1D30TBC1 domain family member 30. (915 aa)
WASF2WASP family member 2. (493 aa)
MSTNMyostatin. (375 aa)
ABITRAMActin binding transcription modulator. (187 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
EPS8L3EPS8 like 3. (592 aa)
ODF2Outer dense fiber of sperm tails 2. (847 aa)
SAXO2Stabilizer of axonemal microtubules 2. (454 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
FSCN1Fascin. (493 aa)
ARHGAP24Rho GTPase activating protein 24. (749 aa)
RDXRadixin. (624 aa)
CCL19C-C motif chemokine. (115 aa)
SH3YL1SH3 and SYLF domain containing 1. (374 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
BIN3Bridging integrator 3. (253 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
AKIRIN1Akirin 1. (192 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
MAKMale germ cell associated kinase. (648 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
PLEK2Pleckstrin 2. (353 aa)
ABI3ABI family member 3. (359 aa)
PFN2Profilin; Belongs to the profilin family. (142 aa)
EVI5LEcotropic viral integration site 5 like. (906 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (361 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
ZMYND10Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family. (439 aa)
FAM98CFamily with sequence similarity 98 member C. (353 aa)
CCL21C-C motif chemokine ligand 21. (133 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FXR2FMR1 autosomal homolog 2. (673 aa)
EPS8L1EPS8 like 1. (784 aa)
KCTD17Potassium channel tetramerization domain containing 17. (307 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
RHOGRas homolog family member G. (191 aa)
A0A4W2ILH9Uncharacterized protein. (72 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (266 aa)
IFT140Intraflagellar transport 140. (1457 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1263 aa)
IFT88Intraflagellar transport 88. (762 aa)
CLN3Battenin. (460 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (600 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
ATMINATM interactor. (899 aa)
A0A4W2BVZ1Uncharacterized protein. (101 aa)
CCP110Centriolar coiled-coil protein 110. (1006 aa)
MIEN1Migration and invasion enhancer 1. (116 aa)
YAP1Yes associated protein 1. (507 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
CDC42EP1CDC42 effector protein 1. (361 aa)
LIMK2LIM domain kinase 2. (628 aa)
DEF8Differentially expressed in FDCP 8 homolog. (447 aa)
SEPTIN9Septin 9; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (585 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (377 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
APCAPC regulator of WNT signaling pathway. (2912 aa)
ENTR1Endosome associated trafficking regulator 1. (432 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1251 aa)
A0A4W2CDP2Uncharacterized protein. (200 aa)
CCDC88ACoiled-coil domain containing 88A. (1842 aa)
MARK4Non-specific serine/threonine protein kinase. (752 aa)
PLCE1Phosphoinositide phospholipase C. (1572 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
SRFSerum response factor. (509 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1623 aa)
GDI2Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (445 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
RIPOR2PL48 domain-containing protein. (1065 aa)
CNTROBCentrobin, centriole duplication and spindle assembly protein. (908 aa)
EVLEnah/Vasp-like. (455 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (754 aa)
DZIP1DAZ interacting zinc finger protein 1. (911 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
KANK1KN motif and ankyrin repeat domains 1. (1384 aa)
SAXO1Stabilizer of axonemal microtubules 1. (477 aa)
TWF1Twinfilin actin binding protein 1. (368 aa)
C15orf62Chromosome 15 open reading frame 62. (176 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
ATG3Autophagy-related protein 3. (314 aa)
HTTHuntingtin. (3119 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
FNBP1LFormin binding protein 1 like. (609 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6919 aa)
KIF24Kinesin family member 24; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1366 aa)
CROCC2Ciliary rootlet coiled-coil, rootletin family member 2. (1712 aa)
TAPT1Transmembrane anterior posterior transformation 1. (761 aa)
DMTNDematin actin binding protein. (467 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1340 aa)
A0A4W2DA03Uncharacterized protein; Belongs to the actin family. (416 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
CDC42Cell division cycle 42. (191 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (306 aa)
GAP43Growth associated protein 43. (260 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1499 aa)
A0A4W2DJN4Uncharacterized protein; Belongs to the actin family. (356 aa)
EPS8L2EPS8 like 2. (713 aa)
FETUBUncharacterized protein. (705 aa)
WASWASP actin nucleation promoting factor. (559 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAP1Signal transducing adaptor family member 1. (288 aa)
PALMParalemmin. (219 aa)
CEP135Centrosomal protein 135. (1139 aa)
MAPK15Mitogen-activated protein kinase. (657 aa)
DCDC2Doublecortin domain containing 2. (475 aa)
A0A4W2DYK7Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (230 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
GPM6AGlycoprotein M6A. (317 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1074 aa)
WDPCPWD repeat containing planar cell polarity effector. (609 aa)
CENPJCentromere protein J. (1354 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RHOQRas homolog family member Q. (209 aa)
IFT20Intraflagellar transport 20. (156 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (493 aa)
CDC42EP4CDC42 effector protein 4. (351 aa)
FAM98AFamily with sequence similarity 98 member A. (517 aa)
MCIDASMulticiliate differentiation and DNA synthesis associated cell cycle protein. (374 aa)
MPHOSPH9M-phase phosphoprotein 9. (1182 aa)
TESK1Testis associated actin remodelling kinase 1. (630 aa)
RALARAS like proto-oncogene A. (206 aa)
HAP1Huntingtin associated protein 1. (574 aa)
A0A4W2EE88Uncharacterized protein. (509 aa)
RP1RP1 axonemal microtubule associated. (2105 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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