STRINGSTRING
A0A4W2C0Y8 A0A4W2C0Y8 NME1 NME1 NEIL3 NEIL3 DNASE1L3 DNASE1L3 NEIL1 NEIL1 CECR2 CECR2 PGBD5 PGBD5 MSH5 MSH5 A0A4W2C4K5 A0A4W2C4K5 DNTT DNTT ALKBH2 ALKBH2 RECQL5 RECQL5 A0A4W2C7A9 A0A4W2C7A9 A0A4W2C8Q6 A0A4W2C8Q6 POLG2 POLG2 FSBP FSBP DICER1 DICER1 ENDOV ENDOV CHD2 CHD2 A0A4W2CBX4 A0A4W2CBX4 FANCM FANCM POLN POLN IGHMBP2 IGHMBP2 SUB1 SUB1 TERT TERT POLE POLE XRCC1 XRCC1 ERCC1 ERCC1 A0A4W2CHD7 A0A4W2CHD7 CHD7 CHD7 LIG1 LIG1 RPS3 RPS3 A0A4W2CII0 A0A4W2CII0 TOP2B TOP2B MCM4 MCM4 TERF1 TERF1 POLD1 POLD1 TOP3B TOP3B XRCC5 XRCC5 SMARCAL1 SMARCAL1 ALKBH3 ALKBH3 ACACB ACACB POLG POLG A0A4W2CRB3 A0A4W2CRB3 BPTF BPTF DSCC1 DSCC1 INO80 INO80 RBBP4 RBBP4 REV1 REV1 SMC5 SMC5 PIF1 PIF1 SPO11 SPO11 SHPRH SHPRH A0A4W2CYF2 A0A4W2CYF2 CHD1 CHD1 DDX1 DDX1 RAD51 RAD51 ERCC6 ERCC6 DCLRE1C DCLRE1C A0A4W2D2X3 A0A4W2D2X3 DCLRE1B DCLRE1B MGME1 MGME1 ERCC6L2 ERCC6L2 SMUG1 SMUG1 DNASE1L2 DNASE1L2 RFC3 RFC3 DNASE1 DNASE1 OGG1 OGG1 CHTF18 CHTF18 NAV2 NAV2 WRNIP1 WRNIP1 MCM2 MCM2 BRIP1 BRIP1 MBD4 MBD4 RAD51C RAD51C MLH1 MLH1 KIAA1257 KIAA1257 A0A4W2BUF7 A0A4W2BUF7 C17orf64 C17orf64 MUS81 MUS81 WRN WRN C11orf80 C11orf80 MCM3 MCM3 APEX1 APEX1 DNA2 DNA2 ERCC2 ERCC2 MSH2 MSH2 GTF2F2 GTF2F2 MCM5 MCM5 DNMT3B DNMT3B SMARCA4 SMARCA4 TM4SF19 TM4SF19 RAD51B RAD51B HAUS3 HAUS3 HFM1 HFM1 FEN1 FEN1 HELB HELB RAD54L2 RAD54L2 MCM8 MCM8 CDK7 CDK7 SUPV3L1 SUPV3L1 ISG20 ISG20 CEP41 CEP41 DNMT1 DNMT1 EXO1 EXO1 TERF2 TERF2 CHD3 CHD3 A0A4W2E4N5 A0A4W2E4N5 A0A4W2E4U3 A0A4W2E4U3 MSH6 MSH6 SRCAP SRCAP A0A4W2E8J1 A0A4W2E8J1 MCM9 MCM9 DQX1 DQX1 MPHOSPH9 MPHOSPH9 DFFB DFFB EP400 EP400 A0A4W2EBN3 A0A4W2EBN3 ASCC3 ASCC3 GEN1 GEN1 A0A4W2EEB8 A0A4W2EEB8 TOP1MT TOP1MT FAN1 FAN1 A0A4W2EGX9 A0A4W2EGX9 CHD4 CHD4 HMGA2 HMGA2 PMS2 PMS2 CHD9 CHD9 FTO FTO RAD9B RAD9B RAD17 RAD17 REV3L REV3L CHD5 CHD5 ERCC5 ERCC5 TEP1 TEP1 POLQ POLQ CHD8 CHD8 A0A4W2EPQ5 A0A4W2EPQ5 ALKBH1 ALKBH1 MLH3 MLH3 TTF2 TTF2 XRCC2 XRCC2 CHD1L CHD1L HELQ HELQ A0A4W2EWF7 A0A4W2EWF7 RFC1 RFC1 HLTF HLTF ANKLE1 ANKLE1 MCM6 MCM6 A0A4W2F279 A0A4W2F279 TDG TDG PMS1 PMS1 DNASE2B DNASE2B A0A4W2F465 A0A4W2F465 APLF APLF TDP2 TDP2 UPF1 UPF1 TOP1 TOP1 ERCC4 ERCC4 CHD6 CHD6 TOP3A TOP3A ENDOG ENDOG PTGES3 PTGES3 METTL4 METTL4 PLD3 PLD3 SMC3 SMC3 RTEL1 RTEL1 SMARCA2 SMARCA2 POLM POLM RUVBL2 RUVBL2 DHX9 DHX9 DMC1 DMC1 FBH1 FBH1 TATDN1 TATDN1 POLL POLL MSH3 MSH3 XRCC6 XRCC6 A0A4W2E1T5 A0A4W2E1T5 SMARCA5 SMARCA5 A0A4W2DZE6 A0A4W2DZE6 REXO2 REXO2 BLM BLM TOP2A TOP2A DDX11 DDX11 MUTYH MUTYH RUVBL1 RUVBL1 EXO5 EXO5 APEX2 APEX2 RSF1 RSF1 DCLRE1A DCLRE1A RAD51D RAD51D LIG3 LIG3 A0A4W2DSD6 A0A4W2DSD6 POLH POLH RFC2 RFC2 POLI POLI A0A4W2DQT9 A0A4W2DQT9 NTHL1 NTHL1 RBBP8 RBBP8 EXOG EXOG ERCC3 ERCC3 MSH4 MSH4 SLX1A SLX1A DNASE2 DNASE2 ATAD5 ATAD5 G3BP1 G3BP1 DDX3X DDX3X MEIOB MEIOB ALKBH4 ALKBH4 MCM7 MCM7 TDP1 TDP1 RECQL RECQL RAD54L RAD54L A0A4W2DG76 A0A4W2DG76 DNMT3A DNMT3A DHX36 DHX36 ZRANB3 ZRANB3 SMARCAD1 SMARCAD1 N6AMT1 N6AMT1 A0A4W2DEF9 A0A4W2DEF9 A0A4W2DC90 A0A4W2DC90 APTX APTX POLK POLK PCNA PCNA A0A4W2D7Q2 A0A4W2D7Q2 RFC4 RFC4 MRE11 MRE11 PRIMPOL PRIMPOL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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A0A4W2C0Y8Reverse transcriptase domain-containing protein. (762 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
NEIL3Nei like DNA glycosylase 3. (620 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (309 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
CECR2CECR2 histone acetyl-lysine reader. (1375 aa)
PGBD5PiggyBac transposable element derived 5. (525 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (832 aa)
A0A4W2C4K5RECA_2 domain-containing protein. (525 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
ALKBH2AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (278 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa)
A0A4W2C7A9Reverse transcriptase domain-containing protein. (704 aa)
A0A4W2C8Q6Reverse transcriptase domain-containing protein. (338 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
FSBPUncharacterized protein. (966 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1998 aa)
ENDOVEndonuclease V. (399 aa)
CHD2Uncharacterized protein. (1827 aa)
A0A4W2CBX4Uncharacterized protein. (152 aa)
FANCMFA complementation group M. (2084 aa)
POLNDNA polymerase nu. (791 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (981 aa)
SUB1SUB1 regulator of transcription. (178 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
XRCC1X-ray repair cross complementing 1. (692 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
A0A4W2CHD7Reverse transcriptase domain-containing protein. (689 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2990 aa)
LIG1DNA ligase. (1303 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
A0A4W2CII0Uncharacterized protein. (678 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1619 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
POLD1DNA polymerase. (1106 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa)
XRCC5X-ray repair cross complementing 5. (813 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (937 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa)
ACACBAcetyl-CoA carboxylase beta. (2455 aa)
POLGDNA polymerase gamma, catalytic subunit. (1217 aa)
A0A4W2CRB3BRCT domain-containing protein. (169 aa)
BPTFBromodomain PHD finger transcription factor. (3194 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (389 aa)
INO80INO80 complex ATPase subunit. (1584 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1253 aa)
SMC5SMC_N domain-containing protein. (1197 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1689 aa)
A0A4W2CYF2PWWP domain-containing protein. (159 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1710 aa)
DDX1DEAD-box helicase 1. (740 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1544 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
DCLRE1BDNA cross-link repair 1B. (542 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa)
ERCC6L2Uncharacterized protein. (1558 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (295 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
RFC3Replication factor C subunit 3. (356 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (282 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
CHTF18Chromosome transmission fidelity factor 18. (978 aa)
NAV2Neuron navigator 2. (2451 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (559 aa)
RAD51CRAD51 paralog C. (442 aa)
MLH1MutL homolog 1. (758 aa)
KIAA1257KIAA1257. (412 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
C17orf64Chromosome 17 open reading frame 64. (234 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
WRNWRN RecQ like helicase. (1409 aa)
C11orf80Chromosome 11 open reading frame 80. (566 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
DNMT3BDNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (862 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1639 aa)
TM4SF19Uncharacterized protein. (209 aa)
RAD51BRAD51 paralog B. (350 aa)
HAUS3HAUS augmin like complex subunit 3. (601 aa)
HFM1Helicase for meiosis 1. (1437 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
HELBDNA helicase B. (1136 aa)
RAD54L2RAD54 like 2. (1468 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
ISG20Interferon stimulated exonuclease gene 20. (171 aa)
CEP41Centrosomal protein 41. (373 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1708 aa)
EXO1Exonuclease 1. (835 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2059 aa)
A0A4W2E4N5Uncharacterized protein. (213 aa)
A0A4W2E4U3Reverse transcriptase domain-containing protein. (729 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
SRCAPUncharacterized protein. (3291 aa)
A0A4W2E8J1Uncharacterized protein. (700 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (719 aa)
MPHOSPH9M-phase phosphoprotein 9. (1182 aa)
DFFBDNA fragmentation factor subunit beta. (341 aa)
EP400E1A binding protein p400. (3096 aa)
A0A4W2EBN3Reverse transcriptase domain-containing protein. (340 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3. (2201 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
A0A4W2EEB8Reverse transcriptase domain-containing protein. (350 aa)
TOP1MTDNA topoisomerase I mitochondrial. (560 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1228 aa)
A0A4W2EGX9Uncharacterized protein. (502 aa)
CHD4Uncharacterized protein. (1920 aa)
HMGA2Uncharacterized protein. (109 aa)
PMS2MutL_C domain-containing protein. (461 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2900 aa)
FTOFTO alpha-ketoglutarate dependent dioxygenase. (521 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
RAD17RAD17 checkpoint clamp loader component. (708 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3133 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1953 aa)
ERCC5ERCC excision repair 5, endonuclease. (1201 aa)
TEP1Telomerase associated protein 1. (2656 aa)
POLQDNA polymerase theta. (2585 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
A0A4W2EPQ5Reverse transcriptase domain-containing protein. (253 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
MLH3MutL homolog 3. (1514 aa)
TTF2Transcription termination factor 2. (1215 aa)
XRCC2X-ray repair cross complementing 2. (319 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
HELQHelicase, POLQ like. (1092 aa)
A0A4W2EWF7Reverse transcriptase domain-containing protein. (683 aa)
RFC1Replication factor C subunit 1. (1146 aa)
HLTFHelicase like transcription factor. (1009 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (667 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
A0A4W2F279Uncharacterized protein. (242 aa)
TDGThymine DNA glycosylase. (454 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (915 aa)
DNASE2BDeoxyribonuclease 2 beta. (357 aa)
A0A4W2F465Uncharacterized protein. (157 aa)
APLFAprataxin and PNKP like factor. (509 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (364 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (769 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2721 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
ENDOGEndonuclease. (299 aa)
PTGES3CS domain-containing protein. (160 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (470 aa)
PLD3Phospholipase D family member 3. (490 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1572 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (488 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
DHX9DExH-box helicase 9. (1287 aa)
DMC1DNA meiotic recombinase 1; Belongs to the RecA family. (340 aa)
FBH1F-box DNA helicase 1. (1045 aa)
TATDN1TatD DNase domain containing 1. (331 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1118 aa)
XRCC6X-ray repair cross complementing 6. (657 aa)
A0A4W2E1T5Uncharacterized protein. (76 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1051 aa)
A0A4W2DZE6Reverse transcriptase domain-containing protein. (346 aa)
REXO2RNA exonuclease 2. (237 aa)
BLMBLM RecQ like helicase. (1430 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1532 aa)
DDX11DEAD/H-box helicase 11. (1012 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (526 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
EXO5Exonuclease 5. (370 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (513 aa)
RSF1Remodeling and spacing factor 1. (1451 aa)
DCLRE1ADNA cross-link repair 1A. (1045 aa)
RAD51DRAD51 paralog D. (418 aa)
LIG3DNA ligase. (943 aa)
A0A4W2DSD6Uncharacterized protein. (513 aa)
POLHDNA polymerase eta. (711 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLIDNA polymerase iota. (760 aa)
A0A4W2DQT9TFIIF_beta domain-containing protein. (115 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (313 aa)
RBBP8RB binding protein 8, endonuclease. (859 aa)
EXOGExo/endonuclease G. (368 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (780 aa)
MSH4MutS homolog 4. (934 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (365 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
G3BP1G3BP stress granule assembly factor 1. (465 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (645 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (303 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (690 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (780 aa)
RAD54LRAD54 like. (749 aa)
A0A4W2DG76Reverse transcriptase domain-containing protein. (247 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (957 aa)
DHX36DEAH-box helicase 36. (1010 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1096 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (260 aa)
A0A4W2DEF9General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (257 aa)
A0A4W2DC90Reverse transcriptase domain-containing protein. (732 aa)
APTXAprataxin. (347 aa)
POLKDNA polymerase kappa. (911 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
A0A4W2D7Q2Reverse transcriptase domain-containing protein. (383 aa)
RFC4Replication factor C subunit 4. (364 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
PRIMPOLPrimase and DNA directed polymerase. (555 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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