(85 nodes) Regulation of DNA biosynthetic process network (Bos indicus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PKIB	Uncharacterized protein. (199 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
	XRCC5	X-ray repair cross complementing 5. (813 aa)
	ING4	Inhibitor of growth protein. (248 aa)
	MAPK1	Mitogen-activated protein kinase. (634 aa)
	EXOSC10	Exosome component 10. (887 aa)
	NVL	Nuclear VCP like. (855 aa)
	DSCC1	DNA replication and sister chromatid cohesion 1. (389 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (806 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (309 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
	GDF2	Growth differentiation factor 2. (431 aa)
	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1. (373 aa)
	TCP1	T-complex 1. (556 aa)
	SMOC2	SPARC related modular calcium binding 2. (655 aa)
	FGFR4	Fibroblast growth factor receptor. (800 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	GRHL2	Grainyhead like transcription factor 2. (609 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
	PARM1	Prostate androgen-regulated mucin-like protein 1. (309 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	A0A4W2DFX9	RRM domain-containing protein. (115 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1654 aa)
	A0A4W2DH79	Uncharacterized protein. (361 aa)
	A0A4W2DJW0	T-complex protein 1 subunit gamma. (536 aa)
	SH2B1	SH2B adaptor protein 1. (860 aa)
	PARN	Poly(A)-specific ribonuclease. (662 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (391 aa)
	GNL3L	G protein nucleolar 3 like. (582 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
	GINS3	GINS complex subunit 3. (216 aa)
	CHTF8	Chromosome transmission fidelity factor 8. (121 aa)
	TFDP1	Transcription factor. (410 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
	NIBAN2	Niban apoptosis regulator 2. (993 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (550 aa)
	TINF2	TERF1 interacting nuclear factor 2. (463 aa)
	DACH1	Dachshund family transcription factor 1. (755 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1339 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	PTGES3	CS domain-containing protein. (160 aa)
	MEN1	Menin 1. (610 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (240 aa)
	POT1	Protection of telomeres 1. (785 aa)
	NEK2	NIMA related kinase 2. (445 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	GINS2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (328 aa)
	TERF2	Telomeric repeat binding factor 2. (543 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (541 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1831 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	PARP3	Poly [ADP-ribose] polymerase. (515 aa)
	CHTF18	Chromosome transmission fidelity factor 18. (978 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	CCDC174	Coiled-coil domain containing 174. (467 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
	JADE1	Jade family PHD finger 1. (872 aa)
	NEK7	NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	CCT6A	Uncharacterized protein. (531 aa)
	DCP2	Decapping mRNA 2. (423 aa)
	CTC1	CST telomere replication complex component 1. (1210 aa)
	POLG2	DNA polymerase gamma 2, accessory subunit. (485 aa)
	WRAP53	WD repeat containing antisense to TP53. (540 aa)
	CCT4	T-complex protein 1 subunit delta. (545 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (470 aa)
	FBXO4	F-box protein 4. (387 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (523 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2DFX9	HNRNPU	A0A4W2DFX9	A0A4W2CVZ4	RRM domain-containing protein.	Heterogeneous nuclear ribonucleoprotein U.	0.740
A0A4W2DH79	A0A4W2DJW0	A0A4W2DH79	A0A4W2DJW0	Uncharacterized protein.	T-complex protein 1 subunit gamma.	0.983
A0A4W2DH79	CCT2	A0A4W2DH79	A0A4W2ECF5	Uncharacterized protein.	Chaperonin containing TCP1 subunit 2.	0.999
A0A4W2DH79	CCT3	A0A4W2DH79	A0A4W2DDK7	Uncharacterized protein.	T-complex protein 1 subunit gamma.	0.983
A0A4W2DH79	CCT4	A0A4W2DH79	A0A4W2CAI2	Uncharacterized protein.	T-complex protein 1 subunit delta.	0.990
A0A4W2DH79	CCT5	A0A4W2DH79	A0A4W2IMM7	Uncharacterized protein.	Chaperonin containing TCP1 subunit 5.	0.998
A0A4W2DH79	CCT7	A0A4W2DH79	A0A4W2FDX9	Uncharacterized protein.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.987
A0A4W2DH79	PTGES3	A0A4W2DH79	A0A4W2FUM1	Uncharacterized protein.	CS domain-containing protein.	0.446
A0A4W2DH79	TCP1	A0A4W2DH79	A0A4W2D1A5	Uncharacterized protein.	T-complex 1.	0.998
A0A4W2DJW0	A0A4W2DH79	A0A4W2DJW0	A0A4W2DH79	T-complex protein 1 subunit gamma.	Uncharacterized protein.	0.983
A0A4W2DJW0	CCT2	A0A4W2DJW0	A0A4W2ECF5	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 2.	0.999
A0A4W2DJW0	CCT4	A0A4W2DJW0	A0A4W2CAI2	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.997
A0A4W2DJW0	CCT5	A0A4W2DJW0	A0A4W2IMM7	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 5.	0.999
A0A4W2DJW0	CCT6A	A0A4W2DJW0	A0A4W2C529	T-complex protein 1 subunit gamma.	Uncharacterized protein.	0.998
A0A4W2DJW0	CCT7	A0A4W2DJW0	A0A4W2FDX9	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.997
A0A4W2DJW0	PTGES3	A0A4W2DJW0	A0A4W2FUM1	T-complex protein 1 subunit gamma.	CS domain-containing protein.	0.462
A0A4W2DJW0	TCP1	A0A4W2DJW0	A0A4W2D1A5	T-complex protein 1 subunit gamma.	T-complex 1.	0.999
ACD	CTC1	A0A4W2CEF1	A0A4W2C8N5	ACD shelterin complex subunit and telomerase recruitment factor.	CST telomere replication complex component 1.	0.682
ACD	POT1	A0A4W2CEF1	A0A4W2GM51	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.997
ACD	STN1	A0A4W2CEF1	A0A4W2DUQ1	ACD shelterin complex subunit and telomerase recruitment factor.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.776

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