STRINGSTRING
TPT1 TPT1 DLGAP5 DLGAP5 MAPRE1 MAPRE1 FBXO5 FBXO5 FAM110A FAM110A YPEL5 YPEL5 NUDC NUDC CNTRL CNTRL SPICE1 SPICE1 A0A4W2D1A4 A0A4W2D1A4 AGBL5 AGBL5 CIAO1 CIAO1 RACGAP1 RACGAP1 CCDC155 CCDC155 CALM1 CALM1 ESPL1 ESPL1 HSPA2 HSPA2 PSRC1 PSRC1 CHMP5 CHMP5 CEP44 CEP44 SPOUT1 SPOUT1 ECT2 ECT2 A0A4W2DBC1 A0A4W2DBC1 RAE1 RAE1 CDC42 CDC42 CSNK1A1 CSNK1A1 CCDC69 CCDC69 A0A4W2DG34 A0A4W2DG34 PKP4 PKP4 KATNAL1 KATNAL1 SEPTIN12 SEPTIN12 SPAST SPAST MAPK1 MAPK1 SPATA5L1 SPATA5L1 CSPP1 CSPP1 EML4 EML4 A0A4W2CLE3 A0A4W2CLE3 RMDN2 RMDN2 GPANK1 GPANK1 CCSAP CCSAP UBXN2B UBXN2B KIF18A KIF18A DCDC1 DCDC1 LSM14A LSM14A TUBG1 TUBG1 TPPP TPPP KIF18B KIF18B MISP MISP CDC27 CDC27 GEM GEM SPDL1 SPDL1 A0A4W2CBR1 A0A4W2CBR1 RMDN1 RMDN1 A0A4W2C9S7 A0A4W2C9S7 A0A4W2C9M0 A0A4W2C9M0 SHCBP1L SHCBP1L KATNB1 KATNB1 CEP95 CEP95 HASPIN HASPIN A0A4W2C8D7 A0A4W2C8D7 LIMK2 LIMK2 CENPV CENPV SPAG5 SPAG5 A0A4W2C4H3 A0A4W2C4H3 KBTBD8 KBTBD8 ASPM ASPM KIF14 KIF14 ARL3 ARL3 DCUN1D5 DCUN1D5 A0A4W2BYW7 A0A4W2BYW7 SKA1 SKA1 HAUS1 HAUS1 MTCL1 MTCL1 A0A4W2BUF7 A0A4W2BUF7 KATNAL2 KATNAL2 KAT5 KAT5 SAC3D1 SAC3D1 PLK1 PLK1 NEDD9 NEDD9 CDADC1 CDADC1 CEP295 CEP295 A0A4W2BL12 A0A4W2BL12 ANKRD53 ANKRD53 MAP10 MAP10 HSF1 HSF1 BCCIP BCCIP ANKFN1 ANKFN1 KIF11 KIF11 IDO1 IDO1 KIF20B KIF20B DDX11 DDX11 NCOR1 NCOR1 CENPF CENPF CYLD CYLD A0A4W2E0S0 A0A4W2E0S0 KIF2A KIF2A TBCK TBCK NUDCD2 NUDCD2 SGO1 SGO1 BIRC5 BIRC5 SIRT2 SIRT2 AURKB AURKB KLHL22 KLHL22 PLK2 PLK2 KNTC1 KNTC1 MAD2L2 MAD2L2 CDC25B CDC25B TDO2 TDO2 CKAP2L CKAP2L YPEL YPEL MAPKBP1 MAPKBP1 ANXA11 ANXA11 SKA3 SKA3 CEP19 CEP19 AUNIP AUNIP CEP85 CEP85 SLC25A6 SLC25A6 HAUS6 HAUS6 LOC113895027 LOC113895027 CDC6 CDC6 MMS19 MMS19 AFMID AFMID KLHL21 KLHL21 ECT2L ECT2L A0A4W2EIV4 A0A4W2EIV4 TTL TTL TPX2 TPX2 DHX35 DHX35 AAAS AAAS TMEM246 TMEM246 TBCCD1 TBCCD1 TBL1XR1 TBL1XR1 HEPACAM2 HEPACAM2 A0A4W2EVL2 A0A4W2EVL2 RCC2 RCC2 KIF20A KIF20A MAP1S MAP1S KYNU KYNU CENPE CENPE HMMR HMMR CCDC117 CCDC117 WDR62 WDR62 FLCN FLCN TNKS TNKS LOC113875854 LOC113875854 SHCBP1 SHCBP1 CBX3 CBX3 SMC3 SMC3 MZT2B MZT2B PRC1 PRC1 ERCC2 ERCC2 KATNA1 KATNA1 A0A4W2GK22 A0A4W2GK22 AURKC AURKC HAUS2 HAUS2 SBDS SBDS MAK MAK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPT1Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (224 aa)
DLGAP5DLG associated protein 5. (846 aa)
MAPRE1Microtubule associated protein RP/EB family member 1. (295 aa)
FBXO5F-box protein 5. (448 aa)
FAM110AFamily with sequence similarity 110 member A. (295 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
NUDCNuclear distribution C, dynein complex regulator. (332 aa)
CNTRLCentriolin. (2334 aa)
SPICE1Uncharacterized protein. (898 aa)
A0A4W2D1A4Dynein light chain. (89 aa)
AGBL5ATP/GTP binding protein like 5. (885 aa)
CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (339 aa)
RACGAP1Rac GTPase activating protein 1. (651 aa)
CCDC155Coiled-coil domain containing 155. (565 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
ESPL1Extra spindle pole bodies like 1, separase. (2100 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
PSRC1Proline and serine rich coiled-coil 1. (365 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
CEP44Centrosomal protein 44. (395 aa)
SPOUT1SPOUT domain containing methyltransferase 1. (376 aa)
ECT2Epithelial cell transforming 2. (944 aa)
A0A4W2DBC1Dynein light chain. (87 aa)
RAE1Ribonucleic acid export 1. (367 aa)
CDC42Cell division cycle 42. (191 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (394 aa)
CCDC69Coiled-coil domain containing 69. (310 aa)
A0A4W2DG34Dynein light chain. (69 aa)
PKP4Plakophilin 4. (1191 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (489 aa)
SEPTIN12Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (315 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (613 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
SPATA5L1Spermatogenesis associated 5 like 1. (767 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1270 aa)
EML4EMAP like 4. (992 aa)
A0A4W2CLE3Uncharacterized protein. (424 aa)
RMDN2Uncharacterized protein. (444 aa)
GPANK1G-patch domain and ankyrin repeats 1. (351 aa)
CCSAPCentriole, cilia and spindle associated protein. (288 aa)
UBXN2BUBX domain protein 2B. (349 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (893 aa)
DCDC1Uncharacterized protein. (1813 aa)
LSM14ALSM14A mRNA processing body assembly factor. (463 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
TPPPTubulin polymerization promoting protein. (330 aa)
KIF18BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (924 aa)
MISPMitotic spindle positioning. (678 aa)
CDC27Cell division cycle 27. (831 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (620 aa)
A0A4W2CBR1Dynein light chain. (63 aa)
RMDN1Regulator of microtubule dynamics 1. (341 aa)
A0A4W2C9S7Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (294 aa)
A0A4W2C9M0SKA2 domain-containing protein. (122 aa)
SHCBP1LSHC binding and spindle associated 1 like. (651 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (689 aa)
CEP95Centrosomal protein 95. (899 aa)
HASPINHistone H3 associated protein kinase. (781 aa)
A0A4W2C8D7TCTP domain-containing protein; Belongs to the TCTP family. (158 aa)
LIMK2LIM domain kinase 2. (628 aa)
CENPVGFA domain-containing protein. (253 aa)
SPAG5Sperm associated antigen 5. (1193 aa)
A0A4W2C4H3Uncharacterized protein. (368 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
ASPMAbnormal spindle microtubule assembly. (3461 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1624 aa)
ARL3ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (189 aa)
DCUN1D5DCN1-like protein. (236 aa)
A0A4W2BYW7Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (374 aa)
SKA1Spindle and kinetochore associated complex subunit 1. (303 aa)
HAUS1HAUS augmin like complex subunit 1. (278 aa)
MTCL1Microtubule crosslinking factor 1. (1914 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (628 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
SAC3D1SAC3 domain containing 1. (358 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (830 aa)
CDADC1Cytidine and dCMP deaminase domain containing 1. (515 aa)
CEP295Centrosomal protein 295. (2612 aa)
A0A4W2BL12Uncharacterized protein. (570 aa)
ANKRD53Ankyrin repeat domain 53. (482 aa)
MAP10Microtubule associated protein 10. (912 aa)
HSF1Heat shock transcription factor 1. (553 aa)
BCCIPBRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (326 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (1164 aa)
KIF11Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (454 aa)
KIF20BKinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1827 aa)
DDX11DEAD/H-box helicase 11. (1012 aa)
NCOR1Nuclear receptor corepressor 1. (2435 aa)
CENPFCentromere protein F. (3259 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
A0A4W2E0S0Dynein light chain. (89 aa)
KIF2AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (744 aa)
TBCKTBC1 domain containing kinase. (924 aa)
NUDCD2NudC domain containing 2. (157 aa)
SGO1Shugoshin 1. (525 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
SIRT2Sirtuin 2. (457 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
KLHL22Kelch like family member 22. (634 aa)
PLK2Serine/threonine-protein kinase PLK. (864 aa)
KNTC1Kinetochore associated 1. (2205 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
CDC25BCell division cycle 25B. (574 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (418 aa)
CKAP2LCytoskeleton associated protein 2 like. (744 aa)
YPELProtein yippee-like; Belongs to the yippee family. (115 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1509 aa)
ANXA11Annexin. (503 aa)
SKA3Spindle and kinetochore associated complex subunit 3. (403 aa)
CEP19Centrosomal protein 19. (163 aa)
AUNIPAurora kinase A and ninein interacting protein. (357 aa)
CEP85Centrosomal protein 85. (764 aa)
SLC25A6Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (410 aa)
HAUS6HAUS augmin like complex subunit 6. (956 aa)
LOC113895027Dynein light chain. (89 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (607 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (336 aa)
KLHL21Kelch like family member 21. (597 aa)
ECT2LEpithelial cell transforming 2 like. (959 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
TTLTubulin tyrosine ligase. (377 aa)
TPX2TPX2 microtubule nucleation factor. (747 aa)
DHX35DEAH-box helicase 35. (703 aa)
AAASAladin WD repeat nucleoporin. (547 aa)
TMEM246Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (762 aa)
TBCCD1TBCC domain containing 1. (580 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (516 aa)
HEPACAM2HEPACAM family member 2. (504 aa)
A0A4W2EVL2Serine/threonine-protein kinase PLK. (548 aa)
RCC2Regulator of chromosome condensation 2. (520 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (888 aa)
MAP1SMicrotubule associated protein 1S. (1066 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2586 aa)
HMMRHyaluronan mediated motility receptor. (854 aa)
CCDC117Coiled-coil domain containing 117. (278 aa)
WDR62WD repeat domain 62. (1516 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
TNKSPoly [ADP-ribose] polymerase. (1339 aa)
LOC113875854Protein kinase domain-containing protein. (258 aa)
SHCBP1SHC binding and spindle associated 1. (674 aa)
CBX3Uncharacterized protein. (183 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
MZT2BUncharacterized protein. (218 aa)
PRC1Protein regulator of cytokinesis 1. (619 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
A0A4W2GK22Dynein light chain. (84 aa)
AURKCProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa)
HAUS2HAUS augmin like complex subunit 2. (235 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
MAKMale germ cell associated kinase. (648 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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