(109 nodes) Myc-type, basic helix-loop-helix (bHLH) domain network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OLIG3	Oligodendrocyte transcription factor 3. (272 aa)
	MLXIPL	MLX interacting protein like. (856 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
	ATOH7	Atonal bHLH transcription factor 7. (152 aa)
	MYOG	Myogenin. (224 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1140 aa)
	MNT	MAX network transcriptional repressor. (585 aa)
	SCX	Scleraxis bHLH transcription factor. (202 aa)
	BHLHA9	Basic helix-loop-helix family member a9. (224 aa)
	MITF	Melanocyte inducing transcription factor. (526 aa)
	ASCL5	Achaete-scute family bHLH transcription factor 5. (189 aa)
	ASCL2	Achaete-scute family bHLH transcription factor 2. (193 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (256 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	ATOH8	Atonal bHLH transcription factor 8. (317 aa)
	SIM1	SIM bHLH transcription factor 1. (766 aa)
	MLX	MAX dimerization protein MLX. (298 aa)
	HIF3A	Hypoxia inducible factor 3 subunit alpha. (688 aa)
	NPAS1	Neuronal PAS domain protein 1. (587 aa)
	TCF24	Transcription factor 24. (167 aa)
	TFEC	Transcription factor EC. (379 aa)
	EPAS1	Endothelial PAS domain protein 1. (928 aa)
	BHLHE22	Basic helix-loop-helix family member e22. (361 aa)
	HES5	Hes family bHLH transcription factor 5. (227 aa)
	HES4	Hes family bHLH transcription factor 4. (258 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	BHLHE23	Basic helix-loop-helix family member e23. (222 aa)
	MGA	MAX dimerization protein MGA. (3065 aa)
	TCF12	Transcription factor 12. (706 aa)
	MYCN	MYCN proto-oncogene, bHLH transcription factor. (463 aa)
	TCFL5	Transcription factor like 5. (506 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	PTF1A	Pancreas associated transcription factor 1a. (326 aa)
	USF3	Upstream transcription factor family member 3. (2228 aa)
	NCOA2	Nuclear receptor coactivator. (1465 aa)
	MYF6	Myogenic factor 6. (422 aa)
	MXD3	MAX dimerization protein 3. (206 aa)
	NCOA3	Nuclear receptor coactivator. (1411 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (329 aa)
	CLOCK	Clock circadian regulator. (844 aa)
	TCF21	Transcription factor 21. (179 aa)
	HES6	Hes family bHLH transcription factor 6. (225 aa)
	BHLHE41	Basic helix-loop-helix family member e41. (485 aa)
	TCF3	Transcription factor 3. (640 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (219 aa)
	TWIST1	Twist family bHLH transcription factor 1. (201 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (394 aa)
	LYL1	LYL1 basic helix-loop-helix family member. (305 aa)
	NHLH2	Nescient helix-loop-helix 2. (133 aa)
	TCF4	Transcription factor 4. (775 aa)
	ID4	Inhibitor of DNA binding 4, HLH protein. (164 aa)
	HELT	Helt bHLH transcription factor. (241 aa)
	NPAS4	Neuronal PAS domain protein 4. (798 aa)
	MLXIP	MLX interacting protein. (940 aa)
	NEUROD2	Neurogenic differentiation factor. (382 aa)
	ASCL3	Achaete-scute family bHLH transcription factor 3. (181 aa)
	HES3	Hes family bHLH transcription factor 3. (186 aa)
	FIGLA	BHLH domain-containing protein. (207 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (583 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1146 aa)
	TCF15	Transcription factor 15. (197 aa)
	MSGN1	Mesogenin 1. (193 aa)
	NCOA1	Nuclear receptor coactivator. (1440 aa)
	TCF23	Transcription factor 23. (214 aa)
	TAL2	TAL bHLH transcription factor 2. (105 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	A0A4W2EX93	BHLH domain-containing protein. (119 aa)
	NEUROG1	Neurogenin 1. (247 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (327 aa)
	ARNTL2	Aryl hydrocarbon receptor nuclear translocator like 2. (633 aa)
	SIM2	SIM bHLH transcription factor 2. (670 aa)
	MYCL	MYCL proto-oncogene, bHLH transcription factor. (394 aa)
	ID3	Inhibitor of DNA binding 3, HLH protein. (119 aa)
	MXD1	MAX dimerization protein 1. (212 aa)
	MAX	MYC associated factor X. (160 aa)
	MXD4	MAX dimerization protein 4. (209 aa)
	TFAP4	Transcription factor AP-4. (335 aa)
	TFEB	Transcription factor EB. (713 aa)
	SOHLH1	BHLH domain-containing protein. (346 aa)
	NPAS2	Neuronal PAS domain protein 2. (849 aa)
	MXI1	MAX interactor 1, dimerization protein. (291 aa)
	NEUROD4	Neurogenic differentiation factor. (330 aa)
	HES2	Hes family bHLH transcription factor 2. (165 aa)
	NHLH1	Nescient helix-loop-helix 1. (133 aa)
	USF1	Upstream transcription factor 1. (310 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (366 aa)
	FERD3L	Fer3 like bHLH transcription factor. (164 aa)
	HES7	Hes family bHLH transcription factor 7. (224 aa)
	NEUROG2	Neurogenin 2. (270 aa)
	A0A4W2GYK2	BHLH domain-containing protein. (164 aa)
	NPAS3	Neuronal PAS domain protein 3. (935 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (154 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (940 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (842 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
	ARNT2	Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (187 aa)
	NEUROG3	Neurogenin 3. (215 aa)
	ATOH1	Atonal bHLH transcription factor 1. (352 aa)
	TWIST2	Twist family bHLH transcription factor 2. (160 aa)
	MSC	Musculin. (197 aa)
	ASCL4	Achaete-scute family bHLH transcription factor 4. (169 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	OLIG1	Oligodendrocyte transcription factor 1. (266 aa)
	BHLHE40	Basic helix-loop-helix family member e40. (412 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2EX93	ARNT	A0A4W2EX93	A0A4W2H228	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator.	0.997
A0A4W2EX93	ARNT2	A0A4W2EX93	A0A4W2HW36	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator 2.	0.929
A0A4W2EX93	ARNTL	A0A4W2EX93	A0A4W2E962	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator like.	0.555
A0A4W2EX93	ARNTL2	A0A4W2EX93	A0A4W2EZZ1	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator like 2.	0.555
A0A4W2EX93	CLOCK	A0A4W2EX93	A0A4W2D933	BHLH domain-containing protein.	Clock circadian regulator.	0.555
A0A4W2EX93	NCOA1	A0A4W2EX93	A0A4W2EM64	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2EX93	NCOA2	A0A4W2EX93	A0A4W2D3H3	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2EX93	NCOA3	A0A4W2EX93	A0A4W2D7I8	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2EX93	NPAS2	A0A4W2EX93	A0A4W2FRU2	BHLH domain-containing protein.	Neuronal PAS domain protein 2.	0.555
A0A4W2GYK2	ARNT	A0A4W2GYK2	A0A4W2H228	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator.	0.892
A0A4W2GYK2	ARNT2	A0A4W2GYK2	A0A4W2HW36	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator 2.	0.835
A0A4W2GYK2	ARNTL	A0A4W2GYK2	A0A4W2E962	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator like.	0.555
A0A4W2GYK2	ARNTL2	A0A4W2GYK2	A0A4W2EZZ1	BHLH domain-containing protein.	Aryl hydrocarbon receptor nuclear translocator like 2.	0.555
A0A4W2GYK2	CLOCK	A0A4W2GYK2	A0A4W2D933	BHLH domain-containing protein.	Clock circadian regulator.	0.555
A0A4W2GYK2	NCOA1	A0A4W2GYK2	A0A4W2EM64	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2GYK2	NCOA2	A0A4W2GYK2	A0A4W2D3H3	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2GYK2	NCOA3	A0A4W2GYK2	A0A4W2D7I8	BHLH domain-containing protein.	Nuclear receptor coactivator.	0.555
A0A4W2GYK2	NPAS2	A0A4W2GYK2	A0A4W2FRU2	BHLH domain-containing protein.	Neuronal PAS domain protein 2.	0.555
ARNT	A0A4W2EX93	A0A4W2H228	A0A4W2EX93	Aryl hydrocarbon receptor nuclear translocator.	BHLH domain-containing protein.	0.997
ARNT	A0A4W2GYK2	A0A4W2H228	A0A4W2GYK2	Aryl hydrocarbon receptor nuclear translocator.	BHLH domain-containing protein.	0.892

page 1 of 36

Server load: low (10%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About