STRINGSTRING
MEIOB MEIOB RFC3 RFC3 CCNA1 CCNA1 CHTF18 CHTF18 WRN WRN PPP6R2 PPP6R2 POLD4 POLD4 TERF2IP TERF2IP CDK3 CDK3 CTC1 CTC1 WRAP53 WRAP53 POLA2 POLA2 ACD ACD TERT TERT LIG1 LIG1 TERF1 TERF1 POLD1 POLD1 RPA2 RPA2 DSCC1 DSCC1 PIF1 PIF1 EXD2 EXD2 RFC4 RFC4 A0A4W2D801 A0A4W2D801 PCNA PCNA ANKRD44 ANKRD44 RFC2 RFC2 SHQ1 SHQ1 PRIM2 PRIM2 STN1 STN1 A0A4W2DY12 A0A4W2DY12 BLM BLM RFC5 RFC5 ANKRD66 ANKRD66 RCBTB2 RCBTB2 CHTF8 CHTF8 ANKRD52 ANKRD52 POLD3 POLD3 RBPMS2 RBPMS2 TINF2 TINF2 NHP2 NHP2 RPA3 RPA3 RFC1 RFC1 ANKRD28 ANKRD28 PPP6C PPP6C NOP10 NOP10 RTEL1 RTEL1 POLD2 POLD2 DNA2 DNA2 POT1 POT1 CCNA2 CCNA2 FEN1 FEN1 RPA1 RPA1 PRIM1 PRIM1 CDK2 CDK2 TRUB1 TRUB1 RCBTB1 RCBTB1 PPP6R3 PPP6R3 MCUB-2 MCUB-2 TERF2 TERF2 RUVBL2 RUVBL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEIOBMeiosis specific with OB-fold. (472 aa)
RFC3Replication factor C subunit 3. (356 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
CHTF18Chromosome transmission fidelity factor 18. (978 aa)
WRNWRN RecQ like helicase. (1409 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (939 aa)
POLD4Uncharacterized protein. (315 aa)
TERF2IPTERF2 interacting protein. (399 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
CTC1CST telomere replication complex component 1. (1210 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (523 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1125 aa)
LIG1DNA ligase. (1303 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
POLD1DNA polymerase. (1106 aa)
RPA2RPA_C domain-containing protein. (270 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (389 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (649 aa)
EXD2Exonuclease 3'-5' domain containing 2. (628 aa)
RFC4Replication factor C subunit 4. (364 aa)
A0A4W2D801Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (274 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
ANKRD44Ankyrin repeat domain 44. (1056 aa)
RFC2Replication factor C subunit 2. (352 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (638 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (391 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
BLMBLM RecQ like helicase. (1430 aa)
RFC5Replication factor C subunit 5. (527 aa)
ANKRD66Ankyrin repeat domain 66. (197 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
ANKRD52Ankyrin repeat domain 52. (1076 aa)
POLD3Uncharacterized protein. (425 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (211 aa)
TINF2TERF1 interacting nuclear factor 2. (463 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
RPA3Replication protein A3. (121 aa)
RFC1Replication factor C subunit 1. (1146 aa)
ANKRD28Ankyrin repeat domain 28. (1138 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
POT1Protection of telomeres 1. (785 aa)
CCNA2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (430 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
TRUB1TruB pseudouridine synthase family member 1. (352 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
MCUB-2H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.