(19 nodes) Synthesis, secretion, and deacylation of Ghrelin network (Bos indicus)

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Your Input:
	SPCS3	Signal peptidase complex subunit 3. (180 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (444 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	SEC11A	Signal peptidase complex catalytic subunit SEC11. (179 aa)
	A0A4W2C9G4	Uncharacterized protein. (232 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (133 aa)
	A0A4W2CKN3	Uncharacterized protein. (191 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
	SEC11C	Signal peptidase complex catalytic subunit SEC11. (192 aa)
	A0A4W2E766	Uncharacterized protein. (73 aa)
	MBOAT4	Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (436 aa)
	SPCS2	Signal peptidase complex subunit 2. (256 aa)
	BCHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (698 aa)
	SPCS1	Signal peptidase complex subunit 1. (102 aa)
	GCG	Glucagon. (180 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
	IGF1	Insulin like growth factor 1. (188 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	A0A4W2C9G4	A0A4W2BND6	A0A4W2C9G4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.420
A0A4W2BND6	A0A4W2E766	A0A4W2BND6	A0A4W2E766	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.819
A0A4W2BND6	FAP	A0A4W2BND6	A0A4W2GPS3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.534
A0A4W2BND6	GCG	A0A4W2BND6	A0A4W2GLX0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon.	0.617
A0A4W2BND6	GHRL	A0A4W2BND6	A0A4W2CA24	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ghrelin and obestatin prepropeptide.	0.830
A0A4W2BND6	IGF1	A0A4W2BND6	A0A4W2I474	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.913
A0A4W2BND6	LEP	A0A4W2BND6	A0A4W2CXJ2	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.594
A0A4W2BND6	PCSK1	A0A4W2BND6	A0A4W2D2P3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.638
A0A4W2C5I5	A0A4W2C9G4	A0A4W2C5I5	A0A4W2C9G4	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.420
A0A4W2C5I5	A0A4W2E766	A0A4W2C5I5	A0A4W2E766	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.819
A0A4W2C5I5	FAP	A0A4W2C5I5	A0A4W2GPS3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.534
A0A4W2C5I5	GCG	A0A4W2C5I5	A0A4W2GLX0	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon.	0.617
A0A4W2C5I5	GHRL	A0A4W2C5I5	A0A4W2CA24	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ghrelin and obestatin prepropeptide.	0.830
A0A4W2C5I5	IGF1	A0A4W2C5I5	A0A4W2I474	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.951
A0A4W2C5I5	LEP	A0A4W2C5I5	A0A4W2CXJ2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.646
A0A4W2C5I5	PCSK1	A0A4W2C5I5	A0A4W2D2P3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.638
A0A4W2C9G4	A0A4W2BND6	A0A4W2C9G4	A0A4W2BND6	Uncharacterized protein.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A4W2C9G4	A0A4W2C5I5	A0A4W2C9G4	A0A4W2C5I5	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.420
A0A4W2C9G4	A0A4W2E766	A0A4W2C9G4	A0A4W2E766	Uncharacterized protein.	Uncharacterized protein.	0.958
A0A4W2C9G4	GHRL	A0A4W2C9G4	A0A4W2CA24	Uncharacterized protein.	Ghrelin and obestatin prepropeptide.	0.970

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