STRINGSTRING
RFC3 RFC3 TOPBP1 TOPBP1 RPA3 RPA3 BARD1 BARD1 RAD17 RAD17 RAD9B RAD9B HUS1 HUS1 BRCA1 BRCA1 RCBTB2 RCBTB2 RFC5 RFC5 BLM BLM A0A4W2DY12 A0A4W2DY12 RAD9A RAD9A ATM ATM RFC2 RFC2 RMI1 RMI1 RBBP8 RBBP8 MEIOB MEIOB ATR ATR RFC4 RFC4 EXD2 EXD2 A0A4W2D2X3 A0A4W2D2X3 SLF1 SLF1 RAD51 RAD51 RPA2 RPA2 ABL1 ABL1 ERCC1 ERCC1 RAD1 RAD1 NBN NBN RAD52 RAD52 RHNO1 RHNO1 MRE11 MRE11 WRN WRN ATRIP ATRIP KAT5 KAT5 BRIP1 BRIP1 TDRD3 TDRD3 EXO1 EXO1 RCBTB1 RCBTB1 RMI2 RMI2 RPA1 RPA1 DNA2 DNA2 TOP3A TOP3A ERCC4 ERCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC3Replication factor C subunit 3. (356 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
RPA3Replication protein A3. (121 aa)
BARD1BRCA1 associated RING domain 1. (773 aa)
RAD17RAD17 checkpoint clamp loader component. (708 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
BRCA1BRCA1 DNA repair associated. (1941 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
RFC5Replication factor C subunit 5. (527 aa)
BLMBLM RecQ like helicase. (1430 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (422 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RFC2Replication factor C subunit 2. (352 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
RBBP8RB binding protein 8, endonuclease. (859 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RFC4Replication factor C subunit 4. (364 aa)
EXD2Exonuclease 3'-5' domain containing 2. (628 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1175 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RPA2RPA_C domain-containing protein. (270 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
RAD1RAD1 checkpoint DNA exonuclease. (279 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
WRNWRN RecQ like helicase. (1409 aa)
ATRIPATR interacting protein. (789 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
TDRD3Tudor domain containing 3. (744 aa)
EXO1Exonuclease 1. (835 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RMI2RecQ mediated genome instability 2. (157 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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