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RFC3 | Replication factor C subunit 3. (356 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1521 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
BARD1 | BRCA1 associated RING domain 1. (773 aa) | ||||
RAD17 | RAD17 checkpoint clamp loader component. (708 aa) | ||||
RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) | ||||
HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) | ||||
BRCA1 | BRCA1 DNA repair associated. (1941 aa) | ||||
RCBTB2 | RCC1 and BTB domain containing protein 2. (554 aa) | ||||
RFC5 | Replication factor C subunit 5. (527 aa) | ||||
BLM | BLM RecQ like helicase. (1430 aa) | ||||
A0A4W2DY12 | RPA_C domain-containing protein. (270 aa) | ||||
RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (422 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) | ||||
RFC2 | Replication factor C subunit 2. (352 aa) | ||||
RMI1 | RecQ mediated genome instability 1. (624 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (859 aa) | ||||
MEIOB | Meiosis specific with OB-fold. (472 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) | ||||
RFC4 | Replication factor C subunit 4. (364 aa) | ||||
EXD2 | Exonuclease 3'-5' domain containing 2. (628 aa) | ||||
A0A4W2D2X3 | Zinc-hook domain-containing protein. (1440 aa) | ||||
SLF1 | SMC5-SMC6 complex localization factor 1. (1175 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
RPA2 | RPA_C domain-containing protein. (270 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1151 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa) | ||||
RAD1 | RAD1 checkpoint DNA exonuclease. (279 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa) | ||||
RAD52 | RAD52 homolog, DNA repair protein. (416 aa) | ||||
RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) | ||||
MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) | ||||
WRN | WRN RecQ like helicase. (1409 aa) | ||||
ATRIP | ATR interacting protein. (789 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1172 aa) | ||||
TDRD3 | Tudor domain containing 3. (744 aa) | ||||
EXO1 | Exonuclease 1. (835 aa) | ||||
RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (157 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1061 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |