STRINGSTRING
BRCA1 BRCA1 BRCA2 BRCA2 BRIP1 BRIP1 RAD51C RAD51C KAT5 KAT5 MUS81 MUS81 WRN WRN MRE11 MRE11 A0A4W2C4K5 A0A4W2C4K5 NBN NBN SPIDR SPIDR RAD51 RAD51 A0A4W2D2X3 A0A4W2D2X3 SLX1A SLX1A RBBP8 RBBP8 RMI1 RMI1 ATM ATM RAD51D RAD51D PALB2 PALB2 BLM BLM EME1 EME1 RAD51AP1 RAD51AP1 SLX4 SLX4 GEN1 GEN1 BARD1 BARD1 XRCC2 XRCC2 TOP3A TOP3A DNA2 DNA2 RAD51B RAD51B RMI2 RMI2 EXO1 EXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA1BRCA1 DNA repair associated. (1941 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
RAD51CRAD51 paralog C. (442 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
WRNWRN RecQ like helicase. (1409 aa)
MRE11MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa)
A0A4W2C4K5RECA_2 domain-containing protein. (525 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa)
SPIDRScaffold protein involved in DNA repair. (831 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
A0A4W2D2X3Zinc-hook domain-containing protein. (1440 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa)
RBBP8RB binding protein 8, endonuclease. (859 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RAD51DRAD51 paralog D. (418 aa)
PALB2Partner and localizer of BRCA2. (1195 aa)
BLMBLM RecQ like helicase. (1430 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
RAD51AP1RAD51 associated protein 1. (366 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
BARD1BRCA1 associated RING domain 1. (773 aa)
XRCC2X-ray repair cross complementing 2. (319 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
RAD51BRAD51 paralog B. (350 aa)
RMI2RecQ mediated genome instability 2. (157 aa)
EXO1Exonuclease 1. (835 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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