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BRCA2 | BRCA2 DNA repair associated. (3420 aa) | ||||
TDRD3 | Tudor domain containing 3. (744 aa) | ||||
BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1172 aa) | ||||
RAD51C | RAD51 paralog C. (442 aa) | ||||
KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) | ||||
WRN | WRN RecQ like helicase. (1409 aa) | ||||
MRE11 | MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (943 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (809 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
A0A4W2D2X3 | Zinc-hook domain-containing protein. (1440 aa) | ||||
EXD2 | Exonuclease 3'-5' domain containing 2. (628 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (859 aa) | ||||
RMI1 | RecQ mediated genome instability 1. (624 aa) | ||||
CHEK1 | Checkpoint kinase 1. (677 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) | ||||
RAD51D | RAD51 paralog D. (418 aa) | ||||
BLM | BLM RecQ like helicase. (1430 aa) | ||||
BRCA1 | BRCA1 DNA repair associated. (1941 aa) | ||||
BARD1 | BRCA1 associated RING domain 1. (773 aa) | ||||
XRCC2 | X-ray repair cross complementing 2. (319 aa) | ||||
TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1061 aa) | ||||
RAD51B | RAD51 paralog B. (350 aa) | ||||
RMI2 | RecQ mediated genome instability 2. (157 aa) | ||||
EXO1 | Exonuclease 1. (835 aa) |