STRINGSTRING
POLE POLE RFC3 RFC3 PARP3 PARP3 GTF2H1 GTF2H1 DDB1 DDB1 POLD4 POLD4 GTF2H4 GTF2H4 A0A4W2C7C3 A0A4W2C7C3 GTF2H3 GTF2H3 RPS27A RPS27A ERCC1 ERCC1 POLD1 POLD1 CUL4A CUL4A XPA XPA RPA2 RPA2 UBC UBC PARP1 PARP1 PARP2 PARP2 A0A4W2D3W4 A0A4W2D3W4 RFC4 RFC4 PCNA PCNA POLK POLK POLE2 POLE2 ERCC3 ERCC3 A0A4W2DPH7 A0A4W2DPH7 RFC2 RFC2 A0A4W2DY12 A0A4W2DY12 RFC5 RFC5 A0A4W2E0Q1 A0A4W2E0Q1 RCBTB2 RCBTB2 POLD3 POLD3 POLE4 POLE4 A0A4W2EGX9 A0A4W2EGX9 ERCC5 ERCC5 A0A4W2EMF1 A0A4W2EMF1 CHD1L CHD1L RPA3 RPA3 RFC1 RFC1 KXD1 KXD1 CUL4B CUL4B POLE3 POLE3 A0A4W2FLF9 A0A4W2FLF9 ERCC4 ERCC4 POLD2 POLD2 ERCC2 ERCC2 RPA1 RPA1 DDB2 DDB2 LOC113878849 LOC113878849 RCBTB1 RCBTB1 RBX1 RBX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
RFC3Replication factor C subunit 3. (356 aa)
PARP3Poly [ADP-ribose] polymerase. (515 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
POLD4Uncharacterized protein. (315 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
A0A4W2C7C3KxDL domain-containing protein. (179 aa)
GTF2H3General transcription factor IIH subunit 3. (402 aa)
RPS27AUbiquitin-like domain-containing protein. (194 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
POLD1DNA polymerase. (1106 aa)
CUL4ACullin 4A; Belongs to the cullin family. (731 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
RPA2RPA_C domain-containing protein. (270 aa)
UBCUbiquitin C. (1146 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
PARP2Poly [ADP-ribose] polymerase. (577 aa)
A0A4W2D3W4Ubiquitin-like domain-containing protein. (160 aa)
RFC4Replication factor C subunit 4. (364 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
POLKDNA polymerase kappa. (911 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (780 aa)
A0A4W2DPH7Ubiquitin-like domain-containing protein. (120 aa)
RFC2Replication factor C subunit 2. (352 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
RFC5Replication factor C subunit 5. (527 aa)
A0A4W2E0Q1Ubiquitin-like domain-containing protein. (77 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
POLD3Uncharacterized protein. (425 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
A0A4W2EGX9Uncharacterized protein. (502 aa)
ERCC5ERCC excision repair 5, endonuclease. (1201 aa)
A0A4W2EMF1Uncharacterized protein. (286 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
RPA3Replication protein A3. (121 aa)
RFC1Replication factor C subunit 1. (1146 aa)
KXD1KxDL domain-containing protein. (212 aa)
CUL4BCullin 4B; Belongs to the cullin family. (734 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
A0A4W2FLF9RING-type domain-containing protein. (108 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
DDB2Damage specific DNA binding protein 2. (426 aa)
LOC113878849General transcription factor IIH subunit. (405 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RBX1RING-type domain-containing protein. (128 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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