STRINGSTRING
PPIE PPIE POLK POLK POLE2 POLE2 TCEANC2 TCEANC2 CCNH CCNH NRDE2 NRDE2 A0A4W2DJ46 A0A4W2DJ46 POLR2J POLR2J MEIOB MEIOB ATAD5 ATAD5 PRPF19 PRPF19 ERCC3 ERCC3 A0A4W2DPH7 A0A4W2DPH7 RFC2 RFC2 LIG3 LIG3 ISY1 ISY1 A0A4W2DUD8 A0A4W2DUD8 A0A4W2DY12 A0A4W2DY12 A0A4W2DYM9 A0A4W2DYM9 RFC5 RFC5 A0A4W2E0Q1 A0A4W2E0Q1 RCBTB2 RCBTB2 A0A4W2E7G3 A0A4W2E7G3 POLD3 POLD3 POLE4 POLE4 A0A4W2EHM9 A0A4W2EHM9 A0A4W2EIH1 A0A4W2EIH1 POLR2I POLR2I AQR AQR A0A4W2EMF1 A0A4W2EMF1 RPA3 RPA3 RFC1 RFC1 KXD1 KXD1 CUL4B CUL4B POLR2D POLR2D POLR2B POLR2B MNAT1 MNAT1 POLE3 POLE3 A0A4W2FLF9 A0A4W2FLF9 POLR2C POLR2C TCEA2 TCEA2 POLD2 POLD2 ERCC2 ERCC2 POLR2H POLR2H USP40 USP40 TCEA3 TCEA3 LOC113887708 LOC113887708 XAB2 XAB2 RPA1 RPA1 POLR2G POLR2G ERCC8 ERCC8 CDK7 CDK7 LOC113878849 LOC113878849 RCBTB1 RCBTB1 A0A4W2IDW0 A0A4W2IDW0 TCEA1 TCEA1 RBX1 RBX1 USP7 USP7 UPK3BL2 UPK3BL2 RFC3 RFC3 GTF2H1 GTF2H1 DDB1 DDB1 POLR2L POLR2L ZNF830 ZNF830 POLD4 POLD4 POLR2E POLR2E EP300 EP300 GTF2H4 GTF2H4 POLR2F POLR2F POLR2A POLR2A PHF3 PHF3 LOC113881217 LOC113881217 A0A4W2C7C3 A0A4W2C7C3 GTF2H3 GTF2H3 RPS27A RPS27A POLE POLE XRCC1 XRCC1 LIG1 LIG1 POLD1 POLD1 CUL4A CUL4A RPA2 RPA2 UBC UBC SPOCD1 SPOCD1 HMGN2 HMGN2 ERCC6 ERCC6 UVSSA UVSSA A0A4W2D3W4 A0A4W2D3W4 RFC4 RFC4 PCNA PCNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
POLKDNA polymerase kappa. (911 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
TCEANC2Transcription elongation factor A N-terminal and central domain containing 2. (223 aa)
CCNHCyclin H; Belongs to the cyclin family. (329 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1155 aa)
A0A4W2DJ46Uncharacterized protein. (380 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (248 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (780 aa)
A0A4W2DPH7Ubiquitin-like domain-containing protein. (120 aa)
RFC2Replication factor C subunit 2. (352 aa)
LIG3DNA ligase. (943 aa)
ISY1Uncharacterized protein. (284 aa)
A0A4W2DUD8Uncharacterized protein. (312 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
A0A4W2DYM9Uncharacterized protein. (98 aa)
RFC5Replication factor C subunit 5. (527 aa)
A0A4W2E0Q1Ubiquitin-like domain-containing protein. (77 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
A0A4W2E7G3RNA_pol_L_2 domain-containing protein. (119 aa)
POLD3Uncharacterized protein. (425 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
A0A4W2EHM9Uncharacterized protein. (194 aa)
A0A4W2EIH1Uncharacterized protein. (95 aa)
POLR2IRNA polymerase II subunit I. (156 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1484 aa)
A0A4W2EMF1Uncharacterized protein. (286 aa)
RPA3Replication protein A3. (121 aa)
RFC1Replication factor C subunit 1. (1146 aa)
KXD1KxDL domain-containing protein. (212 aa)
CUL4BCullin 4B; Belongs to the cullin family. (734 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
A0A4W2FLF9RING-type domain-containing protein. (108 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
TCEA2Transcription elongation factor A2. (356 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (800 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
USP40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1338 aa)
TCEA3Transcription elongation factor A3. (349 aa)
LOC113887708Uncharacterized protein. (377 aa)
XAB2XPA binding protein 2. (855 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
LOC113878849General transcription factor IIH subunit. (405 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
A0A4W2IDW0Uncharacterized protein. (90 aa)
TCEA1Transcription elongation factor A1. (301 aa)
RBX1RING-type domain-containing protein. (128 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
UPK3BL2Uncharacterized protein. (329 aa)
RFC3Replication factor C subunit 3. (356 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
DDB1Damage specific DNA binding protein 1. (1506 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
ZNF830Zinc finger protein 830. (373 aa)
POLD4Uncharacterized protein. (315 aa)
POLR2ERNA polymerase II subunit E. (288 aa)
EP300E1A binding protein p300. (2411 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
POLR2FUncharacterized protein. (127 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2019 aa)
PHF3PHD finger protein 3. (2051 aa)
LOC113881217Uncharacterized protein. (103 aa)
A0A4W2C7C3KxDL domain-containing protein. (179 aa)
GTF2H3General transcription factor IIH subunit 3. (402 aa)
RPS27AUbiquitin-like domain-containing protein. (194 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
XRCC1X-ray repair cross complementing 1. (692 aa)
LIG1DNA ligase. (1303 aa)
POLD1DNA polymerase. (1106 aa)
CUL4ACullin 4A; Belongs to the cullin family. (731 aa)
RPA2RPA_C domain-containing protein. (270 aa)
UBCUbiquitin C. (1146 aa)
SPOCD1SPOC domain containing 1. (1104 aa)
HMGN2Uncharacterized protein. (90 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1544 aa)
UVSSAUV stimulated scaffold protein A. (691 aa)
A0A4W2D3W4Ubiquitin-like domain-containing protein. (160 aa)
RFC4Replication factor C subunit 4. (364 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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