STRINGSTRING
A0A4W2DPH7 A0A4W2DPH7 ATM ATM A0A4W2DXS4 A0A4W2DXS4 A0A4W2E0Q1 A0A4W2E0Q1 PPP2R5C PPP2R5C RNF34 RNF34 PRR5 PRR5 A0A4W2EHH7 A0A4W2EHH7 A0A4W2EHQ1 A0A4W2EHQ1 KXD1 KXD1 CCNG1 CCNG1 TXNDC11 TXNDC11 MAPKAP1 MAPKAP1 CCNA2 CCNA2 PRDM1 PRDM1 PPP2CB PPP2CB PPP2CA PPP2CA CDK2 CDK2 TP53 TP53 CDK1 CDK1 USP7 USP7 CCNA1 CCNA1 RFFL RFFL A0A4W2BU60 A0A4W2BU60 DAXX DAXX A0A4W2C4Q6 A0A4W2C4Q6 CDK3 CDK3 A0A4W2C7C3 A0A4W2C7C3 PPP2R1B PPP2R1B RICTOR RICTOR A0A4W2CET6 A0A4W2CET6 RPS27A RPS27A MDM4 MDM4 A0A4W2CH33 A0A4W2CH33 MDM2 MDM2 UBC UBC SGK1 SGK1 PPP2R1A PPP2R1A A0A4W2D3W4 A0A4W2D3W4 A0A4W2D801 A0A4W2D801
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A4W2DPH7Ubiquitin-like domain-containing protein. (120 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
A0A4W2E0Q1Ubiquitin-like domain-containing protein. (77 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (578 aa)
RNF34Ring finger protein 34. (442 aa)
PRR5Proline rich 5. (409 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
A0A4W2EHQ1Uncharacterized protein. (245 aa)
KXD1KxDL domain-containing protein. (212 aa)
CCNG1CYCLIN domain-containing protein; Belongs to the cyclin family. (295 aa)
TXNDC11Thioredoxin domain containing 11. (956 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
CCNA2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (430 aa)
PRDM1PR/SET domain 1. (842 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (385 aa)
A0A4W2BU60Uncharacterized protein. (82 aa)
DAXXDeath domain associated protein. (735 aa)
A0A4W2C4Q6Uncharacterized protein. (167 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
A0A4W2C7C3KxDL domain-containing protein. (179 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (805 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1789 aa)
A0A4W2CET6Serine/threonine-protein phosphatase. (259 aa)
RPS27AUbiquitin-like domain-containing protein. (194 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
A0A4W2CH33Metallophos domain-containing protein. (127 aa)
MDM2MDM2 proto-oncogene. (689 aa)
UBCUbiquitin C. (1146 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
A0A4W2D3W4Ubiquitin-like domain-containing protein. (160 aa)
A0A4W2D801Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (274 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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