STRINGSTRING
POLD3 POLD3 POLD4 POLD4 RFC3 RFC3 DNA2 DNA2 POLD2 POLD2 RFC1 RFC1 RPA3 RPA3 GINS1 GINS1 RCBTB2 RCBTB2 GINS3 GINS3 RFC5 RFC5 A0A4W2DY12 A0A4W2DY12 PRIM2 PRIM2 RFC2 RFC2 ATAD5 ATAD5 MEIOB MEIOB PCNA PCNA RFC4 RFC4 RPA2 RPA2 POLD1 POLD1 LIG1 LIG1 POLA2 POLA2 GINS4 GINS4 RCBTB1 RCBTB1 PRIM1 PRIM1 RPA1 RPA1 FEN1 FEN1 GINS2 GINS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD3Uncharacterized protein. (425 aa)
POLD4Uncharacterized protein. (315 aa)
RFC3Replication factor C subunit 3. (356 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
RFC1Replication factor C subunit 1. (1146 aa)
RPA3Replication protein A3. (121 aa)
GINS1GINS complex subunit 1. (196 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
GINS3GINS complex subunit 3. (216 aa)
RFC5Replication factor C subunit 5. (527 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
RFC2Replication factor C subunit 2. (352 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
RFC4Replication factor C subunit 4. (364 aa)
RPA2RPA_C domain-containing protein. (270 aa)
POLD1DNA polymerase. (1106 aa)
LIG1DNA ligase. (1303 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (214 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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