STRINGSTRING
A0A4W2EMD5 A0A4W2EMD5 MDM2 MDM2 PSMF1 PSMF1 UBC UBC PSMB7 PSMB7 PSMB1 PSMB1 ZNF385A ZNF385A PSME2 PSME2 A0A4W2D3W4 A0A4W2D3W4 ZNF385C ZNF385C PSMD8 PSMD8 COP1 COP1 PSMA6 PSMA6 CDC25A CDC25A A0A4W2C7C3 A0A4W2C7C3 PSMD11 PSMD11 CDK3 CDK3 PSMB8 PSMB8 PSMD3 PSMD3 CCNA1 CCNA1 PSMB11 PSMB11 PSMD4 PSMD4 A0A4W2D801 A0A4W2D801 PSMB2 PSMB2 PSMC6 PSMC6 PSMA1 PSMA1 PSME4 PSME4 MDM4 MDM4 RPS27A RPS27A PSMC4 PSMC4 A0A4W2E0Q1 A0A4W2E0Q1 A0A4W2DXS4 A0A4W2DXS4 ATM ATM CHEK1 CHEK1 A0A4W2DPH7 A0A4W2DPH7 A0A4W2DNY5 A0A4W2DNY5 PSMD5 PSMD5 ZNF385B ZNF385B A0A4W2ESI7 A0A4W2ESI7 PSMB5 PSMB5 PSMC1 PSMC1 CCNE2 CCNE2 A0A4W2EHQ1 A0A4W2EHQ1 A0A4W2EHH7 A0A4W2EHH7 CDKN1A CDKN1A PSMB9 PSMB9 CCNE1 CCNE1 CHEK2 CHEK2 C17orf113 C17orf113 PSMA4 PSMA4 PSMB3 PSMB3 PSMC2 PSMC2 KXD1 KXD1 PSMD14 PSMD14 PSMA3 PSMA3 PSME1 PSME1 PSMB10 PSMB10 TP53 TP53 PSMD12 PSMD12 CDK2 CDK2 PSMA5 PSMA5 CDKN1B CDKN1B PSMD13 PSMD13 CCNA2 CCNA2 PSME3 PSME3 PSMB4 PSMB4 PSMD7 PSMD7 CDKN1C CDKN1C PSMA7 PSMA7 PSMD2 PSMD2 PSMD9 PSMD9 PSMC3 PSMC3 PSMC5 PSMC5 PSMA8 PSMA8 PSMD1 PSMD1 A0A4W2CQU3 A0A4W2CQU3 PSMB6 PSMB6 A0A4W2CR66 A0A4W2CR66
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A4W2EMD5Proteasome endopeptidase complex. (296 aa)
MDM2MDM2 proto-oncogene. (689 aa)
PSMF1Proteasome inhibitor subunit 1. (270 aa)
UBCUbiquitin C. (1146 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB1Proteasome subunit beta. (241 aa)
ZNF385AZinc finger protein 385A. (393 aa)
PSME2Proteasome activator subunit 2. (239 aa)
A0A4W2D3W4Ubiquitin-like domain-containing protein. (160 aa)
ZNF385CZinc finger protein 385C. (516 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
COP1COP1 E3 ubiquitin ligase. (735 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
CDC25ACell division cycle 25A. (525 aa)
A0A4W2C7C3KxDL domain-containing protein. (179 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (437 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PSMB11Proteasome subunit beta. (289 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (385 aa)
A0A4W2D801Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (274 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
RPS27AUbiquitin-like domain-containing protein. (194 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
A0A4W2E0Q1Ubiquitin-like domain-containing protein. (77 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
CHEK1Checkpoint kinase 1. (677 aa)
A0A4W2DPH7Ubiquitin-like domain-containing protein. (120 aa)
A0A4W2DNY5Uncharacterized protein. (286 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (554 aa)
ZNF385BZinc finger protein 385B. (486 aa)
A0A4W2ESI7Proteasome endopeptidase complex. (157 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (462 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
A0A4W2EHQ1Uncharacterized protein. (245 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
PSMB9Proteasome subunit beta. (219 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
CHEK2Checkpoint kinase 2. (534 aa)
C17orf113Chromosome 17 open reading frame 113. (675 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
PSMB3Proteasome subunit beta. (236 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
KXD1KxDL domain-containing protein. (212 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (320 aa)
PSMA3Proteasome subunit alpha type. (266 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMB10Proteasome subunit beta. (273 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
CCNA2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (430 aa)
PSME3Proteasome activator subunit 3. (231 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
CDKN1CUncharacterized protein. (438 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD2Proteasome 26S subunit, non-ATPase 2. (1688 aa)
PSMD9PDZ domain-containing protein. (221 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (440 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
A0A4W2CQU3Proteasome endopeptidase complex. (239 aa)
PSMB6Proteasome subunit beta. (239 aa)
A0A4W2CR66PROTEASOME_ALPHA_1 domain-containing protein. (200 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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