STRINGSTRING
LOC113894712 LOC113894712 PARP3 PARP3 RFC3 RFC3 A0A4W2ILK0 A0A4W2ILK0 TERF2 TERF2 LOC113887118 LOC113887118 RCBTB1 RCBTB1 RPA1 RPA1 HIST1H2AC HIST1H2AC A0A4W2HJD3 A0A4W2HJD3 FEN1 FEN1 A0A4W2H524 A0A4W2H524 A0A4W2H495 A0A4W2H495 LOC113902148 LOC113902148 VWA5A VWA5A POT1 POT1 POLD2 POLD2 APEX1 APEX1 HIST1H2BA HIST1H2BA A0A4W2FLL3 A0A4W2FLL3 LOC113881709 LOC113881709 POLE3 POLE3 H2AFJ H2AFJ A0A4W2F4C0 A0A4W2F4C0 A0A4W2F316 A0A4W2F316 TDG TDG A0A4W2F1V1 A0A4W2F1V1 LOC113894093 LOC113894093 RFC1 RFC1 VWA5B1 VWA5B1 HIST3H2BB HIST3H2BB RPA3 RPA3 LOC113891914 LOC113891914 HIST2H2AC HIST2H2AC HIST2H2BE HIST2H2BE LOC113895600 LOC113895600 TINF2 TINF2 REC114 REC114 A0A4W2EPN0 A0A4W2EPN0 A0A4W2END9 A0A4W2END9 A0A4W2EN35 A0A4W2EN35 A0A4W2EKY1 A0A4W2EKY1 PNKP PNKP H2AFV H2AFV POLE4 POLE4 POLD3 POLD3 A0A4W2E9V8 A0A4W2E9V8 RCBTB2 RCBTB2 A0A4W2E576 A0A4W2E576 HIST1H2AK HIST1H2AK A0A4W2E2F4 A0A4W2E2F4 RFC5 RFC5 A0A4W2DZL0 A0A4W2DZL0 LOC113888629 LOC113888629 A0A4W2DY12 A0A4W2DY12 A0A4W2DXQ9 A0A4W2DXQ9 A0A4W2DVZ3 A0A4W2DVZ3 MUTYH MUTYH APEX2 APEX2 LIG3 LIG3 A0A4W2DT21 A0A4W2DT21 A0A4W2DSD6 A0A4W2DSD6 A0A4W2DS81 A0A4W2DS81 A0A4W2DRH1 A0A4W2DRH1 HIST2H2BF HIST2H2BF RFC2 RFC2 NTHL1 NTHL1 ATAD5 ATAD5 A0A4W2DLX6 A0A4W2DLX6 MEIOB MEIOB A0A4W2DGW5 A0A4W2DGW5 POLE2 POLE2 A0A4W2DBR6 A0A4W2DBR6 A0A4W2DBN9 A0A4W2DBN9 LOC113894257 LOC113894257 LOC113890991 LOC113890991 VWA5B2 VWA5B2 PCNA PCNA RFC4 RFC4 LOC113887714 LOC113887714 A0A4W2D6U7 A0A4W2D6U7 SMUG1 SMUG1 A0A4W2D280 A0A4W2D280 PARG PARG A0A4W2CXN3 A0A4W2CXN3 PARP2 PARP2 PARP1 PARP1 A0A4W2CUU2 A0A4W2CUU2 A0A4W2CUJ6 A0A4W2CUJ6 RPA2 RPA2 POLD1 POLD1 TERF1 TERF1 LIG1 LIG1 A0A4W2CHW6 A0A4W2CHW6 A0A4W2CGH5 A0A4W2CGH5 A0A4W2CG17 A0A4W2CG17 XRCC1 XRCC1 POLE POLE ACD ACD A0A4W2CDJ5 A0A4W2CDJ5 A0A4W2CAS1 A0A4W2CAS1 A0A4W2C7C4 A0A4W2C7C4 A0A4W2C6H8 A0A4W2C6H8 A0A4W2C6E9 A0A4W2C6E9 LOC113881235 LOC113881235 LOC113887723 LOC113887723 LOC113881683 LOC113881683 A0A4W2C3R7 A0A4W2C3R7 NEIL1 NEIL1 NEIL3 NEIL3 A0A4W2BZU2 A0A4W2BZU2 A0A4W2BY98 A0A4W2BY98 TERF2IP TERF2IP POLD4 POLD4 A0A4W2BUF7 A0A4W2BUF7 MBD4 MBD4 OGG1 OGG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC113894712Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
PARP3Poly [ADP-ribose] polymerase. (515 aa)
RFC3Replication factor C subunit 3. (356 aa)
A0A4W2ILK0Histone domain-containing protein; Belongs to the histone H2B family. (118 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
LOC113887118Histone H2A; Belongs to the histone H2A family. (109 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
HIST1H2ACHistone H2A; Belongs to the histone H2A family. (130 aa)
A0A4W2HJD3Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
A0A4W2H524Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
A0A4W2H495Histone H2A; Belongs to the histone H2A family. (93 aa)
LOC113902148Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
VWA5AVon Willebrand factor A domain containing 5A. (785 aa)
POT1Protection of telomeres 1. (785 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
HIST1H2BAHistone H2B; Belongs to the histone H2B family. (127 aa)
A0A4W2FLL3Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (99 aa)
LOC113881709Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
H2AFJHistone H2A; Belongs to the histone H2A family. (129 aa)
A0A4W2F4C0Histone H2A; Belongs to the histone H2A family. (130 aa)
A0A4W2F316Histone domain-containing protein; Belongs to the histone H2B family. (112 aa)
TDGThymine DNA glycosylase. (454 aa)
A0A4W2F1V1Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
LOC113894093Histone H2A; Belongs to the histone H2A family. (128 aa)
RFC1Replication factor C subunit 1. (1146 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1208 aa)
HIST3H2BBHistone H2B; Belongs to the histone H2B family. (126 aa)
RPA3Replication protein A3. (121 aa)
LOC113891914Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
HIST2H2ACHistone H2A; Belongs to the histone H2A family. (129 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
LOC113895600Histone H2B; Belongs to the histone H2B family. (126 aa)
TINF2TERF1 interacting nuclear factor 2. (463 aa)
REC114REC114 meiotic recombination protein. (255 aa)
A0A4W2EPN0Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
A0A4W2END9Histone H2B; Belongs to the histone H2B family. (67 aa)
A0A4W2EN35Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A4W2EKY1Histone H2B; Belongs to the histone H2B family. (67 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (550 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (128 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
POLD3Uncharacterized protein. (425 aa)
A0A4W2E9V8Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (554 aa)
A0A4W2E576Histone H2B; Belongs to the histone H2B family. (67 aa)
HIST1H2AKHistone H2A; Belongs to the histone H2A family. (130 aa)
A0A4W2E2F4Histone H2B; Belongs to the histone H2B family. (67 aa)
RFC5Replication factor C subunit 5. (527 aa)
A0A4W2DZL0Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC113888629Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
A0A4W2DXQ9Histone domain-containing protein; Belongs to the histone H2B family. (153 aa)
A0A4W2DVZ3Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (526 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (513 aa)
LIG3DNA ligase. (943 aa)
A0A4W2DT21Histone domain-containing protein; Belongs to the histone H2B family. (69 aa)
A0A4W2DSD6Uncharacterized protein. (513 aa)
A0A4W2DS81Histone domain-containing protein; Belongs to the histone H2B family. (112 aa)
A0A4W2DRH1Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BFHistone H2B; Belongs to the histone H2B family. (140 aa)
RFC2Replication factor C subunit 2. (352 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (313 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
A0A4W2DLX6Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
A0A4W2DGW5Histone domain-containing protein; Belongs to the histone H2B family. (118 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
A0A4W2DBR6Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
A0A4W2DBN9Histone H2B; Belongs to the histone H2B family. (149 aa)
LOC113894257Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC113890991Histone H2B; Belongs to the histone H2B family. (122 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1247 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
RFC4Replication factor C subunit 4. (364 aa)
LOC113887714Histone H2A; Belongs to the histone H2A family. (130 aa)
A0A4W2D6U7Histone H2B; Belongs to the histone H2B family. (67 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (295 aa)
A0A4W2D280Histone H2B; Belongs to the histone H2B family. (67 aa)
PARGPoly(ADP-ribose) glycohydrolase. (946 aa)
A0A4W2CXN3Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
PARP2Poly [ADP-ribose] polymerase. (577 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
A0A4W2CUU2Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A4W2CUJ6Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RPA2RPA_C domain-containing protein. (270 aa)
POLD1DNA polymerase. (1106 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (436 aa)
LIG1DNA ligase. (1303 aa)
A0A4W2CHW6Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A4W2CGH5Histone H2B; Belongs to the histone H2B family. (125 aa)
A0A4W2CG17Histone domain-containing protein; Belongs to the histone H2B family. (124 aa)
XRCC1X-ray repair cross complementing 1. (692 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (523 aa)
A0A4W2CDJ5Histone H2B; Belongs to the histone H2B family. (122 aa)
A0A4W2CAS1Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
A0A4W2C7C4Histone H2B; Belongs to the histone H2B family. (126 aa)
A0A4W2C6H8Histone H2B; Belongs to the histone H2B family. (147 aa)
A0A4W2C6E9Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
LOC113881235Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC113887723Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC113881683Histone H2A; Belongs to the histone H2A family. (130 aa)
A0A4W2C3R7Histone H2B; Belongs to the histone H2B family. (126 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
NEIL3Nei like DNA glycosylase 3. (620 aa)
A0A4W2BZU2Histone domain-containing protein; Belongs to the histone H2B family. (165 aa)
A0A4W2BY98Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TERF2IPTERF2 interacting protein. (399 aa)
POLD4Uncharacterized protein. (315 aa)
A0A4W2BUF7DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (531 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (559 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (16%) [HD]