(63 nodes) DNA Damage Bypass network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAD18	RAD18 E3 ubiquitin protein ligase. (501 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	DDB1	Damage specific DNA binding protein 1. (1506 aa)
	POLD4	Uncharacterized protein. (315 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7. (1001 aa)
	A0A4W2C218	Uncharacterized protein. (627 aa)
	USP43	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1138 aa)
	A0A4W2C7C3	KxDL domain-containing protein. (179 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (194 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
	POLD1	DNA polymerase. (1106 aa)
	TRIM65	Tripartite motif containing 65. (548 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (767 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (731 aa)
	RPA2	RPA_C domain-containing protein. (270 aa)
	UBC	Ubiquitin C. (1146 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1253 aa)
	PCLAF	PAF domain-containing protein. (114 aa)
	A0A4W2D3W4	Ubiquitin-like domain-containing protein. (160 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
	POLK	DNA polymerase kappa. (911 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	MEIOB	Meiosis specific with OB-fold. (472 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
	ATAD5	ATPase family AAA domain containing 5. (1893 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1347 aa)
	A0A4W2DPH7	Ubiquitin-like domain-containing protein. (120 aa)
	POLI	DNA polymerase iota. (760 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	POLH	DNA polymerase eta. (711 aa)
	SPRTN	SprT-like N-terminal domain. (487 aa)
	TRIM25	Tripartite motif containing 25. (631 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	A0A4W2DY12	RPA_C domain-containing protein. (270 aa)
	RFC5	Replication factor C subunit 5. (527 aa)
	SPATA5	Spermatogenesis associated 5. (868 aa)
	A0A4W2E0Q1	Ubiquitin-like domain-containing protein. (77 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (554 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	POLD3	Uncharacterized protein. (425 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (816 aa)
	ISG15	ISG15 ubiquitin like modifier. (154 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (120 aa)
	TRIM47	Tripartite motif containing 47. (649 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3133 aa)
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	A0A4W2EP37	PAF domain-containing protein. (92 aa)
	RPA3	Replication protein A3. (121 aa)
	UBE2B	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (180 aa)
	RFC1	Replication factor C subunit 1. (1146 aa)
	KXD1	KxDL domain-containing protein. (212 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (734 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	A0A4W2FLF9	RING-type domain-containing protein. (108 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (580 aa)
	WDR48	WD repeat domain 48. (677 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (261 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RBX1	RING-type domain-containing protein. (128 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2C218	A0A4W2D3W4	A0A4W2C218	A0A4W2D3W4	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.468
A0A4W2C218	A0A4W2DPH7	A0A4W2C218	A0A4W2DPH7	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.468
A0A4W2C218	A0A4W2E0Q1	A0A4W2C218	A0A4W2E0Q1	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.551
A0A4W2C218	ISG15	A0A4W2C218	A0A4W2EEE2	Uncharacterized protein.	ISG15 ubiquitin like modifier.	0.699
A0A4W2C218	PCNA	A0A4W2C218	A0A4W2D824	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.425
A0A4W2C218	POLI	A0A4W2C218	A0A4W2DQY5	Uncharacterized protein.	DNA polymerase iota.	0.409
A0A4W2C218	RFC1	A0A4W2C218	A0A4W2EXE5	Uncharacterized protein.	Replication factor C subunit 1.	0.406
A0A4W2C218	RFC2	A0A4W2C218	A0A4W2DR52	Uncharacterized protein.	Replication factor C subunit 2.	0.406
A0A4W2C218	RFC3	A0A4W2C218	A0A4W2BMK1	Uncharacterized protein.	Replication factor C subunit 3.	0.406
A0A4W2C218	RFC4	A0A4W2C218	A0A4W2D7H2	Uncharacterized protein.	Replication factor C subunit 4.	0.406
A0A4W2C218	RFC5	A0A4W2C218	A0A4W2DZN7	Uncharacterized protein.	Replication factor C subunit 5.	0.417
A0A4W2C218	RPA1	A0A4W2C218	A0A4W2HLX4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.420
A0A4W2C218	RPS27A	A0A4W2C218	A0A4W2CFE2	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.468
A0A4W2C218	UBA7	A0A4W2C218	A0A4W2BYD2	Uncharacterized protein.	Ubiquitin like modifier activating enzyme 7.	0.487
A0A4W2C218	UBC	A0A4W2C218	A0A4W2CUP5	Uncharacterized protein.	Ubiquitin C.	0.551
A0A4W2C218	UBE2L6	A0A4W2C218	A0A4W2EKJ9	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family.	0.917
A0A4W2C7C3	A0A4W2D3W4	A0A4W2C7C3	A0A4W2D3W4	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.488
A0A4W2C7C3	A0A4W2DPH7	A0A4W2C7C3	A0A4W2DPH7	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.488
A0A4W2C7C3	A0A4W2E0Q1	A0A4W2C7C3	A0A4W2E0Q1	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.508
A0A4W2C7C3	RPS27A	A0A4W2C7C3	A0A4W2CFE2	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.488

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