STRINGSTRING
EP300 EP300 CTNNB1 CTNNB1 SMAD2 SMAD2 PSMD3 PSMD3 YAP1 YAP1 PSMB8 PSMB8 NINJ2 NINJ2 PSMD11 PSMD11 TEAD4 TEAD4 CBFB CBFB PSMA6 PSMA6 PSMC4 PSMC4 RPS27A RPS27A TGFB1 TGFB1 TEAD1 TEAD1 HES4 HES4 PSMA1 PSMA1 A0A4W2CQU3 A0A4W2CQU3 PSMB6 PSMB6 A0A4W2CR66 A0A4W2CR66 MDM2 MDM2 PSMF1 PSMF1 UBC UBC PSMB7 PSMB7 PSMB1 PSMB1 PSME2 PSME2 A0A4W2D3W4 A0A4W2D3W4 PSMD4 PSMD4 RUNX3 RUNX3 PSMB2 PSMB2 PSMC6 PSMC6 FNDC3B FNDC3B PSMD5 PSMD5 CREBBP CREBBP HES1 HES1 A0A4W2DLR6 A0A4W2DLR6 A0A4W2DNY5 A0A4W2DNY5 A0A4W2DPH7 A0A4W2DPH7 SMURF1 SMURF1 SMAD4 SMAD4 MAML2 MAML2 TEAD3 TEAD3 A0A4W2DXS4 A0A4W2DXS4 MAML3 MAML3 A0A4W2E0Q1 A0A4W2E0Q1 LEF1 LEF1 PSMD8 PSMD8 KAT2A KAT2A SMURF2 SMURF2 FNDC3A FNDC3A ZFHX3 ZFHX3 CCND1 CCND1 PSMB9 PSMB9 A0A4W2EHH7 A0A4W2EHH7 CCN2 CCN2 ZFHX4 ZFHX4 A0A4W2EMD5 A0A4W2EMD5 PSMC1 PSMC1 SNW1 SNW1 PSMB5 PSMB5 A0A4W2ER70 A0A4W2ER70 A0A4W2ESI7 A0A4W2ESI7 SMAD3 SMAD3 PSMA3 PSMA3 A0A4W2EVH5 A0A4W2EVH5 MAML1 MAML1 PSMD14 PSMD14 PSMC2 PSMC2 KAT2B KAT2B PSMB3 PSMB3 TCF7 TCF7 SRC SRC PSMA4 PSMA4 RBPJ RBPJ RBPJL RBPJL BRD2 BRD2 PSMD1 PSMD1 TCF7L2 TCF7L2 PSMC5 PSMC5 PSMC3 PSMC3 PSMD9 PSMD9 PSMD2 PSMD2 PSMA7 PSMA7 PSMD7 PSMD7 PSMB4 PSMB4 PSME3 PSME3 TEAD2 TEAD2 PSMD13 PSMD13 TCF7L1 TCF7L1 PSMA5 PSMA5 PSMD12 PSMD12 TP53 TP53 PSMB10 PSMB10 PSME1 PSME1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EP300E1A binding protein p300. (2411 aa)
CTNNB1Catenin beta 1. (774 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
YAP1Yes associated protein 1. (507 aa)
PSMB8Proteasome subunit beta. (276 aa)
NINJ2Ninjurin 2. (178 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (437 aa)
TEAD4TEA domain transcription factor 4. (652 aa)
CBFBCore-binding factor subunit beta. (187 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
RPS27AUbiquitin-like domain-containing protein. (194 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
TEAD1TEA domain transcription factor 1. (648 aa)
HES4Hes family bHLH transcription factor 4. (258 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
A0A4W2CQU3Proteasome endopeptidase complex. (239 aa)
PSMB6Proteasome subunit beta. (239 aa)
A0A4W2CR66PROTEASOME_ALPHA_1 domain-containing protein. (200 aa)
MDM2MDM2 proto-oncogene. (689 aa)
PSMF1Proteasome inhibitor subunit 1. (270 aa)
UBCUbiquitin C. (1146 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSME2Proteasome activator subunit 2. (239 aa)
A0A4W2D3W4Ubiquitin-like domain-containing protein. (160 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (385 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (434 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
FNDC3BFibronectin type III domain containing 3B. (1245 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (554 aa)
CREBBPCREB binding protein. (2435 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
A0A4W2DLR6Uncharacterized protein. (1401 aa)
A0A4W2DNY5Uncharacterized protein. (286 aa)
A0A4W2DPH7Ubiquitin-like domain-containing protein. (120 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAML2Mastermind like transcriptional coactivator 2. (1127 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
MAML3Mastermind like transcriptional coactivator 3. (1113 aa)
A0A4W2E0Q1Ubiquitin-like domain-containing protein. (77 aa)
LEF1Lymphoid enhancer binding factor 1. (430 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (1071 aa)
FNDC3AFibronectin type III domain containing 3A. (1212 aa)
ZFHX3Zinc finger homeobox 3. (3706 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
PSMB9Proteasome subunit beta. (219 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
CCN2Cellular communication network factor 2. (464 aa)
ZFHX4Zinc finger homeobox 4. (3594 aa)
A0A4W2EMD5Proteasome endopeptidase complex. (296 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (462 aa)
SNW1SNW domain containing 1. (536 aa)
PSMB5Proteasome subunit beta. (263 aa)
A0A4W2ER70C2H2-type domain-containing protein. (399 aa)
A0A4W2ESI7Proteasome endopeptidase complex. (157 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PSMA3Proteasome subunit alpha type. (266 aa)
A0A4W2EVH5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1130 aa)
MAML1Mastermind like transcriptional coactivator 1. (1013 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (320 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
KAT2BLysine acetyltransferase 2B. (990 aa)
PSMB3Proteasome subunit beta. (236 aa)
TCF7Transcription factor 7. (473 aa)
SRCTyrosine-protein kinase. (559 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
BRD2Bromodomain containing 2. (803 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
TCF7L2Transcription factor 7 like 2. (652 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (440 aa)
PSMD9PDZ domain-containing protein. (221 aa)
PSMD2Proteasome 26S subunit, non-ATPase 2. (1688 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSME3Proteasome activator subunit 3. (231 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSME1Proteasome activator subunit 1. (249 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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