(38 nodes) RHOH GTPase cycle network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

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gene fusions

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protein homology

Your Input:
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1416 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
	STOM	PHB domain-containing protein. (501 aa)
	TMEM59	Uncharacterized protein. (334 aa)
	PAK2	Non-specific serine/threonine protein kinase. (600 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (225 aa)
	WDR11	WD repeat domain 11. (1253 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
	SPATA5	Spermatogenesis associated 5. (868 aa)
	PAK4	Non-specific serine/threonine protein kinase. (593 aa)
	A0A4W2E4J7	NIPSNAP domain-containing protein. (262 aa)
	RALGAPA2	Ral GTPase activating protein catalytic alpha subunit 2. (1886 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (816 aa)
	SLC1A5	Amino acid transporter. (539 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	DBN1	Drebrin 1. (726 aa)
	NSFL1C	NSFL1 cofactor. (372 aa)
	TFRC	Transferrin receptor. (842 aa)
	JUP	Junction plakoglobin. (745 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (204 aa)
	VANGL1	Vang-like protein. (537 aa)
	ZAP70	Tyrosine-protein kinase. (617 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	NIPSNAP2	NIPSNAP domain-containing protein. (286 aa)
	SLC4A7	Anion exchange protein. (1241 aa)
	RALGAPA1	Ral GTPase activating protein catalytic alpha subunit 1. (2494 aa)
	FAM91A1	Family with sequence similarity 91 member A1. (838 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
	UBXN2B	UBX domain protein 2B. (349 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (767 aa)
	A0A4W2CP57	Uncharacterized protein. (285 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
	OSBPL11	Oxysterol-binding protein; Belongs to the OSBP family. (758 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2CP57	LAMTOR1	A0A4W2CP57	A0A4W2GVK3	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.417
A0A4W2CP57	MTR	A0A4W2CP57	A0A4W2CH68	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.404
A0A4W2CP57	PAK1	A0A4W2CP57	A0A4W2I0B8	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.428
A0A4W2CP57	PAK2	A0A4W2CP57	A0A4W2DKA0	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.430
A0A4W2CP57	RAB7A	A0A4W2CP57	A0A4W2BR87	Uncharacterized protein.	RAB7A, member RAS oncogene family.	0.446
A0A4W2CP57	UACA	A0A4W2CP57	A0A4W2D3H1	Uncharacterized protein.	Uveal autoantigen with coiled-coil domains and ankyrin repeats.	0.437
A0A4W2CP57	VCP	A0A4W2CP57	A0A4W2EB72	Uncharacterized protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.536
A0A4W2E4J7	DBT	A0A4W2E4J7	A0A4W2D542	NIPSNAP domain-containing protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.461
A0A4W2E4J7	LAMTOR1	A0A4W2E4J7	A0A4W2GVK3	NIPSNAP domain-containing protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.452
A0A4W2E4J7	MTR	A0A4W2E4J7	A0A4W2CH68	NIPSNAP domain-containing protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.427
A0A4W2E4J7	PAK4	A0A4W2E4J7	A0A4W2E386	NIPSNAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.436
A0A4W2E4J7	PAK5	A0A4W2E4J7	A0A4W2CVT1	NIPSNAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.432
A0A4W2E4J7	PAK6	A0A4W2E4J7	A0A4W2EIH7	NIPSNAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.432
A0A4W2E4J7	SPATA5	A0A4W2E4J7	A0A4W2DZS4	NIPSNAP domain-containing protein.	Spermatogenesis associated 5.	0.433
A0A4W2E4J7	SPATA5L1	A0A4W2E4J7	A0A4W2CNJ0	NIPSNAP domain-containing protein.	Spermatogenesis associated 5 like 1.	0.433
A0A4W2E4J7	VCP	A0A4W2E4J7	A0A4W2EB72	NIPSNAP domain-containing protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.450
A0A4W2E4J7	ZAP70	A0A4W2E4J7	A0A4W2EMH8	NIPSNAP domain-containing protein.	Tyrosine-protein kinase.	0.402
ARHGDIA	ARHGDIG	A0A4W2EHS7	A0A4W2DLB5	Rho GDP dissociation inhibitor alpha.	Rho GDP dissociation inhibitor gamma.	0.893
ARHGDIG	ARHGDIA	A0A4W2DLB5	A0A4W2EHS7	Rho GDP dissociation inhibitor gamma.	Rho GDP dissociation inhibitor alpha.	0.893
CAV1	JUP	A0A4W2CJB9	A0A4W2IRN6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin.	0.443

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