STRINGSTRING
EGR2 EGR2 JUNB JUNB LYL1 LYL1 EGR1 EGR1 ASCL1 ASCL1 A0A4W2DGD3 A0A4W2DGD3 ID2 ID2 SGK1 SGK1 RRAD RRAD EGR4 EGR4 FOSL1 FOSL1 ASCL2 ASCL2 ELK1 ELK1 ID4 ID4 CREB1 CREB1 FOSB FOSB TRIB1 TRIB1 CHD4 CHD4 NAB1 NAB1 ID3 ID3 NAB2 NAB2 TRIB2 TRIB2 ARC ARC EGR3 EGR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR2Early growth response 2. (485 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
LYL1LYL1 basic helix-loop-helix family member. (305 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
A0A4W2DGD3Uncharacterized protein. (472 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
EGR4Early growth response 4. (482 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
ELK1ETS transcription factor ELK1. (432 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (164 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
CHD4Uncharacterized protein. (1920 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
NAB2NGFI-A binding protein 2. (525 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
EGR3Early growth response 3. (387 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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