STRINGSTRING
PIK3R1 PIK3R1 BAD BAD EGFR EGFR FOXO3 FOXO3 A0A4W2CHX7 A0A4W2CHX7 AKT2 AKT2 GRB2 GRB2 FGFR2 FGFR2 SHC4 SHC4 MAPK1 MAPK1 PIK3CD PIK3CD MTOR MTOR GAS6 GAS6 GSK3B GSK3B AXL AXL FGFR3 FGFR3 BCL2L11 BCL2L11 CSDE1 CSDE1 MAP2K1 MAP2K1 A0A4W2D608 A0A4W2D608 A0A4W2D7S8 A0A4W2D7S8 KDR KDR PDGFRB PDGFRB EIF4E EIF4E HGF HGF IL6R IL6R NRG2 NRG2 SHC3 SHC3 NRAS NRAS PIK3CA PIK3CA EIF4E1B EIF4E1B ERAS ERAS A0A4W2DS38 A0A4W2DS38 KRAS KRAS PIK3CB PIK3CB ERBB2 ERBB2 VEGFA VEGFA PDGFD PDGFD NF1 NF1 A0A4W2E8M1 A0A4W2E8M1 STAT3 STAT3 EIF4EBP1 EIF4EBP1 AKT3 AKT3 PDGFC PDGFC PRKCG PRKCG FGF2 FGF2 SOS2 SOS2 MET MET RPS6 RPS6 PLCG1 PLCG1 BRAF BRAF A0A4W2ETA9 A0A4W2ETA9 A0A4W2EUW0 A0A4W2EUW0 A0A4W2EVV5 A0A4W2EVV5 PIK3R3 PIK3R3 JAK2 JAK2 PRKCB PRKCB MAPK3 MAPK3 IGF1R IGF1R SOS1 SOS1 TGFA TGFA PRKCA PRKCA A0A4W2G4L9 A0A4W2G4L9 PTEN PTEN JAK1 JAK1 BCL2L1 BCL2L1 A0A4W2GYG4 A0A4W2GYG4 BAX BAX A0A4W2H7Y7 A0A4W2H7Y7 HRAS HRAS GAB1 GAB1 A0A4W2HDU0 A0A4W2HDU0 TBCA TBCA A0A4W2HP99 A0A4W2HP99 EIF4E2 EIF4E2 IGF1 IGF1 IL6 IL6 ERBB3 ERBB3 PLCG2 PLCG2 PDGFRA PDGFRA SHC1 SHC1 SRC SRC AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 A0A4W2BS34 A0A4W2BS34 RPS6KB1 RPS6KB1 RAF1 RAF1 RPS6KB2 RPS6KB2 NRG1 NRG1 BCL2 BCL2 PDGFB PDGFB PDGFA PDGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
FOXO3Forkhead box O3. (617 aa)
A0A4W2CHX7BH4_2 domain-containing protein. (233 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
GAS6Growth arrest specific 6. (671 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
AXLAXL receptor tyrosine kinase. (878 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
A0A4W2D608BH4_2 domain-containing protein. (238 aa)
A0A4W2D7S8Uncharacterized protein. (191 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
IL6RInterleukin 6 receptor. (464 aa)
NRG2Neuregulin 2. (853 aa)
SHC3SHC adaptor protein 3. (587 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (132 aa)
ERASES cell expressed Ras. (185 aa)
A0A4W2DS38Uncharacterized protein. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (394 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (558 aa)
NF1Neurofibromin 1. (3024 aa)
A0A4W2E8M1BH4_2 domain-containing protein. (173 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (178 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
A0A4W2ETA9Uncharacterized protein. (132 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
A0A4W2EVV5Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
PIK3R3Uncharacterized protein. (461 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
TGFATransforming growth factor alpha. (228 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
A0A4W2H7Y7BH4_2 domain-containing protein. (195 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
A0A4W2HDU0Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (229 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
A0A4W2HP99Tubulin-specific chaperone A; Belongs to the TBCA family. (83 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
IGF1Insulin like growth factor 1. (188 aa)
IL6Interleukin 6. (208 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
SHC1SHC adaptor protein 1. (584 aa)
SRCTyrosine-protein kinase. (559 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
NRG1Neuregulin 1. (713 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (24%) [HD]