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MED1 MED1 MMP2 MMP2 MAPK12 MAPK12 A0A4W2CFU1 A0A4W2CFU1 DLL3 DLL3 SOS1 SOS1 IGF1R IGF1R MAPK3 MAPK3 JUN JUN IGF1 IGF1 TP53 TP53 RB1 RB1 HBEGF HBEGF CDKN2C CDKN2C CDKN1B CDKN1B ESR2 ESR2 HRAS HRAS E2F2 E2F2 E2F1 E2F1 CARM1 CARM1 AKT2 AKT2 GRB2 GRB2 PTK2 PTK2 SHC4 SHC4 MAPK1 MAPK1 PIK3CD PIK3CD MDM2 MDM2 MTOR MTOR DLL4 DLL4 GNAS GNAS ADCY2 ADCY2 DLL1 DLL1 CCDC170 CCDC170 PTRHD1 PTRHD1 ADCY6 ADCY6 CSDE1 CSDE1 MAP2K1 MAP2K1 MAPK8 MAPK8 ADCY4 ADCY4 NCOA3 NCOA3 ERAS ERAS A0A4W2D8G7 A0A4W2D8G7 MMP9 MMP9 A0A4W2D9N9 A0A4W2D9N9 PIK3CA PIK3CA E2F3 E2F3 ADCY9 ADCY9 A0A4W2BS34 A0A4W2BS34 RPS6KB1 RPS6KB1 RAF1 RAF1 RPS6KB2 RPS6KB2 BCL2 BCL2 MMP20 MMP20 MAPK11 MAPK11 JAG2 JAG2 PIK3R1 PIK3R1 BAD BAD EGFR EGFR BAX BAX PRKACB PRKACB A0A4W2GYG4 A0A4W2GYG4 ESR1 ESR1 PRKACA PRKACA MAPK10 MAPK10 A0A4W2DC91 A0A4W2DC91 NOTCH3 NOTCH3 FOS FOS SHC3 SHC3 NRAS NRAS A0A4W2G5Q0 A0A4W2G5Q0 A0A4W2G4L9 A0A4W2G4L9 MAP2K2 MAP2K2 PIK3R2 PIK3R2 AKT1 AKT1 SRC SRC JAG1 JAG1 SHC1 SHC1 MAPK9 MAPK9 PIK3R3 PIK3R3 ABCB11 ABCB11 A0A4W2EUW0 A0A4W2EUW0 NOTCH2 NOTCH2 SP1 SP1 BRAF BRAF ADCY5 ADCY5 ADCY3 ADCY3 CDK4 CDK4 A0A4W2EHH7 A0A4W2EHH7 CDKN1A CDKN1A SOS2 SOS2 AKT3 AKT3 CCND1 CCND1 ADCY1 ADCY1 ADCY8 ADCY8 NOTCH4 NOTCH4 ADCY7 ADCY7 ERBB2 ERBB2 GPER1 GPER1 PIK3CB PIK3CB A0A4W2DXS4 A0A4W2DXS4 KRAS KRAS NOTCH1 NOTCH1 NCOR1 NCOR1 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
A0A4W2CFU1Protein kinase domain-containing protein. (79 aa)
DLL3Delta like canonical Notch ligand 3. (645 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
IGF1Insulin like growth factor 1. (188 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa)
RB1RB transcriptional corepressor 1. (928 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ESR2Estrogen receptor 2. (527 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
E2F1E2F transcription factor 1. (437 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (608 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MDM2MDM2 proto-oncogene. (689 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
GNASGNAS complex locus. (1004 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (722 aa)
CCDC170Coiled-coil domain containing 170. (714 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
NCOA3Nuclear receptor coactivator. (1411 aa)
ERASES cell expressed Ras. (185 aa)
A0A4W2D8G7Uncharacterized protein. (65 aa)
MMP9Matrix metallopeptidase 9. (712 aa)
A0A4W2D9N9Uncharacterized protein. (590 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
E2F3E2F transcription factor 3. (465 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
A0A4W2BS34Uncharacterized protein. (147 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1239 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
BADBCL2 associated agonist of cell death. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
NOTCH3Notch receptor 3. (2313 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SHC3SHC adaptor protein 3. (587 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
A0A4W2G5Q0Protein kinase domain-containing protein. (79 aa)
A0A4W2G4L9Uncharacterized protein. (148 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIK3R2Uncharacterized protein. (724 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
SRCTyrosine-protein kinase. (559 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SHC1SHC adaptor protein 1. (584 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PIK3R3Uncharacterized protein. (461 aa)
ABCB11ATP binding cassette subfamily B member 11. (1323 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
NOTCH2Notch receptor 2. (2471 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
A0A4W2EHH7Uncharacterized protein. (91 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
NOTCH4Notch receptor 4. (1992 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1710 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
A0A4W2DXS4RING-type domain-containing protein. (131 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NOTCH1Notch receptor 1. (2533 aa)
NCOR1Nuclear receptor corepressor 1. (2435 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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