STRINGSTRING
MCM2 MCM2 RNASEH2A RNASEH2A ATAD5 ATAD5 MEIOB MEIOB MCM7 MCM7 POLE2 POLE2 TOR1A TOR1A PCNA PCNA RNASEH1 RNASEH1 RFC4 RFC4 YJU2 YJU2 GDAP2 GDAP2 SSBP1 SSBP1 A0A4W2CWS1 A0A4W2CWS1 CPNE1 CPNE1 CPNE3 CPNE3 RPA2 RPA2 POLD1 POLD1 MCM4 MCM4 LIG1 LIG1 PPIL3 PPIL3 POLE POLE POLA2 POLA2 TOR3A TOR3A CPNE7 CPNE7 EXOC8 EXOC8 CPNE5 CPNE5 MCM3 MCM3 POLD4 POLD4 RNASEH2B RNASEH2B PRIM2 PRIM2 STN1 STN1 CHRAC1 CHRAC1 A0A4W2DY12 A0A4W2DY12 RFC5 RFC5 MACROD2 MACROD2 A0A4W2E776 A0A4W2E776 MCM9 MCM9 FAM162B FAM162B MACROD1 MACROD1 POLD3 POLD3 TOR1B TOR1B MCMDC2 MCMDC2 GEN1 GEN1 POLE4 POLE4 RAD17 RAD17 TOR2A TOR2A PARP14 PARP14 SASS6 SASS6 RPA3 RPA3 RFC1 RFC1 CPNE4 CPNE4 MCM6 MCM6 A0A4W2F272 A0A4W2F272 A0A4W2F3C1 A0A4W2F3C1 A0A4W2FF60 A0A4W2FF60 FAM162A FAM162A POLE3 POLE3 CPNE2 CPNE2 POLD2 POLD2 DNA2 DNA2 C16orf70 C16orf70 MCM5 MCM5 CPNE8 CPNE8 TM4SF19 TM4SF19 FEN1 FEN1 RFC2 RFC2 RPA1 RPA1 PRIM1 PRIM1 CPNE6 CPNE6 CABP5 CABP5 PRKRIP1 PRKRIP1 RFC3 RFC3 CPNE9 CPNE9 WRNIP1 WRNIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (299 aa)
ATAD5ATPase family AAA domain containing 5. (1893 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
TOR1ATorsin. (326 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (326 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (298 aa)
RFC4Replication factor C subunit 4. (364 aa)
YJU2YJU2 splicing factor homolog. (320 aa)
GDAP2Ganglioside induced differentiation associated protein 2. (497 aa)
SSBP1Single stranded DNA binding protein 1. (159 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
CPNE1Copine 1. (542 aa)
CPNE3Copine 3. (533 aa)
RPA2RPA_C domain-containing protein. (270 aa)
POLD1DNA polymerase. (1106 aa)
MCM4DNA helicase; Belongs to the MCM family. (836 aa)
LIG1DNA ligase. (1303 aa)
PPIL3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
TOR3ATorsin family 3 member A. (317 aa)
CPNE7Copine 7. (549 aa)
EXOC8Exocyst complex component 8. (710 aa)
CPNE5Copine 5. (614 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
POLD4Uncharacterized protein. (315 aa)
RNASEH2BUncharacterized protein. (309 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (510 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (391 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
RFC5Replication factor C subunit 5. (527 aa)
MACROD2Mono-ADP ribosylhydrolase 2. (452 aa)
A0A4W2E776Uncharacterized protein. (129 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1139 aa)
FAM162BFamily with sequence similarity 162 member B. (163 aa)
MACROD1Mono-ADP ribosylhydrolase 1. (465 aa)
POLD3Uncharacterized protein. (425 aa)
TOR1BTorsin. (336 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (906 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (120 aa)
RAD17RAD17 checkpoint clamp loader component. (708 aa)
TOR2ATorsin. (321 aa)
PARP14Poly(ADP-ribose) polymerase family member 14. (1671 aa)
SASS6SAS-6 centriolar assembly protein. (738 aa)
RPA3Replication protein A3. (121 aa)
RFC1Replication factor C subunit 1. (1146 aa)
CPNE4Copine 4. (592 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
A0A4W2F272Uncharacterized protein. (97 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
A0A4W2FF60Uncharacterized protein. (128 aa)
FAM162AFamily with sequence similarity 162 member A. (156 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
CPNE2Copine 2. (548 aa)
POLD2DNA polymerase delta 2, accessory subunit. (580 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
MCM5DNA helicase; Belongs to the MCM family. (892 aa)
CPNE8Copine 8. (576 aa)
TM4SF19Uncharacterized protein. (209 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
CPNE6Copine 6. (557 aa)
CABP5Calcium binding protein 5. (173 aa)
PRKRIP1Uncharacterized protein. (186 aa)
RFC3Replication factor C subunit 3. (356 aa)
CPNE9Copine family member 9. (604 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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