STRINGSTRING
CNP CNP ERCC1 ERCC1 NUTF2 NUTF2 MICAL1 MICAL1 FANCM FANCM FAAP100 FAAP100 FANCA FANCA FANCI FANCI MICAL3 MICAL3 UBE2T UBE2T MUS81 MUS81 ATRIP ATRIP MLH1 MLH1 A0A4W2BMD6 A0A4W2BMD6 BRCA2 BRCA2 FANCF FANCF BRIP1 BRIP1 RAD51C RAD51C TELO2 TELO2 CENPS CENPS A0A4W2HXL3 A0A4W2HXL3 N4BP2L1 N4BP2L1 FANCC FANCC RMI2 RMI2 RPA1 RPA1 LOC113888691 LOC113888691 WDR48 WDR48 RTEL1 RTEL1 TOP3A TOP3A ERCC4 ERCC4 A0A4W2F3C1 A0A4W2F3C1 N4BP2 N4BP2 RPA3 RPA3 SASS6 SASS6 POLQ POLQ REV3L REV3L PMS2 PMS2 FAN1 FAN1 A0A4W2EEW9 A0A4W2EEW9 BRCA1 BRCA1 PTGDR2 PTGDR2 SLX4 SLX4 EME1 EME1 BLM BLM A0A4W2DY12 A0A4W2DY12 PALB2 PALB2 FANCE FANCE FANCD2 FANCD2 POLH POLH POLI POLI RMI1 RMI1 SLX1A SLX1A HES1 HES1 USP1 USP1 ATR ATR POLK POLK TENT2 TENT2 POLN POLN RAD51 RAD51 FAAP24 FAAP24 A0A4W2CWS1 A0A4W2CWS1 REV1 REV1 RPA2 RPA2 FANCG FANCG TOP3B TOP3B FANCL FANCL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (351 aa)
NUTF2Nuclear transport factor 2. (127 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1070 aa)
FANCMFA complementation group M. (2084 aa)
FAAP100FA core complex associated protein 100. (918 aa)
FANCAFA complementation group A. (1449 aa)
FANCIFA complementation group I. (1340 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (2087 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
ATRIPATR interacting protein. (789 aa)
MLH1MutL homolog 1. (758 aa)
A0A4W2BMD6Uncharacterized protein. (742 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
FANCFFA complementation group F. (359 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1172 aa)
RAD51CRAD51 paralog C. (442 aa)
TELO2Telomere maintenance 2. (825 aa)
CENPSCentromere protein S. (139 aa)
A0A4W2HXL3Uncharacterized protein. (76 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (243 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
RMI2RecQ mediated genome instability 2. (157 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
LOC113888691PITH domain containing 1. (211 aa)
WDR48WD repeat domain 48. (677 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1266 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
A0A4W2F3C1RPA_C domain-containing protein. (250 aa)
N4BP2NEDD4 binding protein 2. (1767 aa)
RPA3Replication protein A3. (121 aa)
SASS6SAS-6 centriolar assembly protein. (738 aa)
POLQDNA polymerase theta. (2585 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3133 aa)
PMS2MutL_C domain-containing protein. (461 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1228 aa)
A0A4W2EEW9Uncharacterized protein. (1936 aa)
BRCA1BRCA1 DNA repair associated. (1941 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (414 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1754 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
BLMBLM RecQ like helicase. (1430 aa)
A0A4W2DY12RPA_C domain-containing protein. (270 aa)
PALB2Partner and localizer of BRCA2. (1195 aa)
FANCEFA complementation group E. (541 aa)
FANCD2FA complementation group D2. (1446 aa)
POLHDNA polymerase eta. (711 aa)
POLIDNA polymerase iota. (760 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (366 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
POLKDNA polymerase kappa. (911 aa)
TENT2Terminal nucleotidyltransferase 2. (576 aa)
POLNDNA polymerase nu. (791 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
FAAP24FA core complex associated protein 24. (215 aa)
A0A4W2CWS1RPA_C domain-containing protein. (253 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1253 aa)
RPA2RPA_C domain-containing protein. (270 aa)
FANCGFA complementation group G. (622 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa)
FANCLFA complementation group L. (377 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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