STRINGSTRING
RHOA RHOA RALB RALB AKT1 AKT1 PIK3R2 PIK3R2 MAP2K2 MAP2K2 PIP5K1B PIP5K1B AGPAT5 AGPAT5 SRMS SRMS LPAR5 LPAR5 GAB2 GAB2 PTGFR PTGFR GRM2 GRM2 TSC2 TSC2 GRM5 GRM5 A0A4W2BND6 A0A4W2BND6 ADCY9 ADCY9 DGKH DGKH PLCB3 PLCB3 RAF1 RAF1 GRM4 GRM4 A0A4W2BTN1 A0A4W2BTN1 A0A4W2BTN2 A0A4W2BTN2 A0A4W2BVW3 A0A4W2BVW3 A0A4W2BWE6 A0A4W2BWE6 A0A4W2BY61 A0A4W2BY61 PDGFB PDGFB PIK3R5 PIK3R5 A0A4W2C5I5 A0A4W2C5I5 PDGFA PDGFA PIK3R1 PIK3R1 GNA12 GNA12 EGFR EGFR A0A4W2CAP3 A0A4W2CAP3 A0A4W2CAP7 A0A4W2CAP7 A0A4W2CAS0 A0A4W2CAS0 CYTH3 CYTH3 PLD2 PLD2 AGPAT2 AGPAT2 PLPP1 PLPP1 PLCB1 PLCB1 AVPR1B AVPR1B AKT2 AKT2 GRB2 GRB2 ZNF408 ZNF408 RUFY4 RUFY4 CXCR2 CXCR2 RRAS2 RRAS2 SHC4 SHC4 MAPK1 MAPK1 AVP AVP PIK3CD PIK3CD MTOR MTOR DNM1 DNM1 AVPR1A AVPR1A PLCB2 PLCB2 DGKI DGKI GNAS GNAS AGPAT4 AGPAT4 ADCY2 ADCY2 PLA2G4E PLA2G4E A0A4W2CZ07 A0A4W2CZ07 RAPGEF3 RAPGEF3 PTRHD1 PTRHD1 ADCY6 ADCY6 RHEBL1 RHEBL1 SPHK2 SPHK2 A0A4W2D456 A0A4W2D456 A0A4W2DC91 A0A4W2DC91 A0A4W2EF50 A0A4W2EF50 F2 F2 PLA2G4D PLA2G4D SOS2 SOS2 PDGFC PDGFC AKT3 AKT3 RALA RALA A0A4W2EA01 A0A4W2EA01 ADCY1 ADCY1 PLCB4 PLCB4 PLA2G4A PLA2G4A CYTH1 CYTH1 PIK3R6 PIK3R6 ADCY8 ADCY8 PDGFD PDGFD ADCY7 ADCY7 RALGDS RALGDS PIK3CB PIK3CB KRAS KRAS A0A4W2DX14 A0A4W2DX14 SPHK1 SPHK1 A0A4W2DWN2 A0A4W2DWN2 TSC1 TSC1 ERAS ERAS PIK3CA PIK3CA DGKE DGKE NRAS NRAS DGKA DGKA PIK3CG PIK3CG DNM2 DNM2 SYK SYK SHC3 SHC3 LPAR6 LPAR6 GRM7 GRM7 PLPP3 PLPP3 MRAS MRAS PDGFRB PDGFRB FCER1A FCER1A KIT KIT PRKCA PRKCA GNA13 GNA13 AGPAT1 AGPAT1 F2R F2R AGPAT3 AGPAT3 DGKD DGKD PTPN11 PTPN11 A0A4W2GYG4 A0A4W2GYG4 RRAS RRAS HRAS HRAS GAB1 GAB1 LPAR2 LPAR2 PIP5K1C PIP5K1C DGKZ DGKZ GRM8 GRM8 ARL17A ARL17A GRM1 GRM1 MAPK3 MAPK3 SOS1 SOS1 CYTH2 CYTH2 JMJD7 JMJD7 INSR INSR AGT AGT ARF1 ARF1 DGKB DGKB CSDE1 CSDE1 MAP2K1 MAP2K1 A0A4W2D4V5 A0A4W2D4V5 ADCY4 ADCY4 RAPGEF4 RAPGEF4 DNM3 DNM3 MS4A2 MS4A2 A0A4W2EHI1 A0A4W2EHI1 ARF6 ARF6 FYN FYN PTK6 PTK6 PLA2G4F PLA2G4F ADCY3 ADCY3 PLCG1 PLCG1 ADCY5 ADCY5 A0A4W2EQN1 A0A4W2EQN1 LPAR1 LPAR1 DGKG DGKG RHEB RHEB PLD1 PLD1 PTK2B PTK2B A0A4W2EUW0 A0A4W2EUW0 PIP5K1A PIP5K1A A0A4W2EV68 A0A4W2EV68 GRM6 GRM6 CXCL8 CXCL8 PIK3R3 PIK3R3 AGTR1 AGTR1 CYTH4 CYTH4 GRM3 GRM3 LPAR3 LPAR3 PLCG2 PLCG2 PDGFRA PDGFRA KITLG KITLG SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOARas homolog family member A. (193 aa)
RALBRAS like proto-oncogene B. (206 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
PIK3R2Uncharacterized protein. (724 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (519 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (397 aa)
SRMSTyrosine-protein kinase. (504 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (367 aa)
GAB2GRB2 associated binding protein 2. (666 aa)
PTGFRG_PROTEIN_RECEP_F1_2 domain-containing protein. (362 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
TSC2TSC complex subunit 2. (1887 aa)
GRM5Glutamate metabotropic receptor 5. (1185 aa)
A0A4W2BND6IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
DGKHDiacylglycerol kinase. (1214 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GRM4Glutamate metabotropic receptor 4. (770 aa)
A0A4W2BTN1Uncharacterized protein. (508 aa)
A0A4W2BTN2Ig-like domain-containing protein. (130 aa)
A0A4W2BVW3Ig-like domain-containing protein. (218 aa)
A0A4W2BWE6Ig-like domain-containing protein. (204 aa)
A0A4W2BY61G_PROTEIN_RECEP_F1_2 domain-containing protein. (346 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (893 aa)
A0A4W2C5I5Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (401 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GNA12G protein subunit alpha 12. (382 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
A0A4W2CAP3Ig-like domain-containing protein. (182 aa)
A0A4W2CAP7Ig-like domain-containing protein. (213 aa)
A0A4W2CAS0Ig-like domain-containing protein. (223 aa)
CYTH3Cytohesin 3. (418 aa)
PLD2Phospholipase. (1088 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (395 aa)
PLPP1Phospholipid phosphatase 1. (286 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ZNF408Zinc finger protein 408. (731 aa)
RUFY4RUN and FYVE domain containing 4. (571 aa)
CXCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
RRAS2RAS related 2. (204 aa)
SHC4SHC adaptor protein 4. (630 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
AVPArginine vasopressin. (199 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
DGKIDiacylglycerol kinase. (1065 aa)
GNASGNAS complex locus. (1004 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (425 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PLA2G4EPhospholipase A2. (860 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
RHEBL1RHEB like 1. (195 aa)
SPHK2Sphingosine kinase 2. (661 aa)
A0A4W2D456acidPPc domain-containing protein. (368 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
A0A4W2EF50G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (372 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (631 aa)
PLA2G4DPhospholipase A2. (808 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
RALARAS like proto-oncogene A. (206 aa)
A0A4W2EA01Uncharacterized protein. (48 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
PLA2G4APhospholipase A2. (749 aa)
CYTH1Cytohesin 1. (455 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (756 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (558 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
RALGDSUncharacterized protein. (1077 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
A0A4W2DX14Ig-like domain-containing protein. (160 aa)
SPHK1Sphingosine kinase 1. (489 aa)
A0A4W2DWN2Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
TSC1TSC complex subunit 1. (1165 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DGKEDiacylglycerol kinase. (564 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DGKADiacylglycerol kinase. (734 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1171 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
SYKTyrosine-protein kinase. (628 aa)
SHC3SHC adaptor protein 3. (587 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
GRM7Glutamate metabotropic receptor 7. (926 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
MRASMuscle RAS oncogene homolog. (259 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
FCER1AFc fragment of IgE receptor Ia. (260 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNA13G protein subunit alpha 13. (377 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
DGKDDiacylglycerol kinase. (1215 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
RRASRAS related. (218 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (695 aa)
DGKZDiacylglycerol kinase. (1193 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
ARL17AUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
GRM1Glutamate metabotropic receptor 1. (1192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1598 aa)
CYTH2Uncharacterized protein. (400 aa)
JMJD7Jumonji domain containing 7. (316 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
DGKBDiacylglycerol kinase. (803 aa)
CSDE1Cold shock domain containing E1. (844 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
A0A4W2EHI1Uncharacterized protein. (170 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (148 aa)
FYNTyrosine-protein kinase. (537 aa)
PTK6Tyrosine-protein kinase. (450 aa)
PLA2G4FPhospholipase A2. (845 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
A0A4W2EQN1Phorbol-ester/DAG-type domain-containing protein. (322 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
DGKGDiacylglycerol kinase. (791 aa)
RHEBUncharacterized protein. (214 aa)
PLD1Phospholipase. (1126 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1008 aa)
A0A4W2EUW0Uncharacterized protein. (559 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
A0A4W2EV68acidPPc domain-containing protein. (458 aa)
GRM6Glutamate metabotropic receptor 6. (871 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PIK3R3Uncharacterized protein. (461 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CYTH4Cytohesin 4. (394 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (249 aa)
SHC1SHC adaptor protein 1. (584 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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