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| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | A0A4W2E8M1 | BH4_2 domain-containing protein. (173 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (485 aa) |
| | A0A4W2IDQ2 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | RPRM | Reprimo, TP53 dependent G2 arrest mediator homolog. (109 aa) |
| | IGF1 | Insulin like growth factor 1. (188 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (499 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (291 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (426 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | ADGRB2 | Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1558 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | SESN1 | Sestrin 1. (551 aa) |
| | A0A4W2H7Y7 | BH4_2 domain-containing protein. (195 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | CRYZ | Crystallin zeta. (330 aa) |
| | BBC3 | Uncharacterized protein. (193 aa) |
| | BCL2L1 | BH4_2 domain-containing protein. (233 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | CNTD2 | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (332 aa) |
| | LOC113891379 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa) |
| | AIFM2 | Apoptosis inducing factor mitochondria associated 2. (384 aa) |
| | A0A4W2G5Q0 | Protein kinase domain-containing protein. (79 aa) |
| | FAM76B | Family with sequence similarity 76 member B. (316 aa) |
| | ADGRB3 | Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1522 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | TSC2 | TSC complex subunit 2. (1887 aa) |
| | EI24 | EI24 autophagy associated transmembrane protein. (340 aa) |
| | PIDD1 | P53-induced death domain protein 1. (946 aa) |
| | BCL2 | BCL2 apoptosis regulator. (229 aa) |
| | SHISA5 | Shisa family member 5. (216 aa) |
| | SESN3 | Sestrin 3. (492 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | FAS | Fas cell surface death receptor. (323 aa) |
| | A0A4W2C4Q6 | Uncharacterized protein. (167 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | A0A4W2CFU1 | Protein kinase domain-containing protein. (79 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | A0A4W2CHX7 | BH4_2 domain-containing protein. (233 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa) |
| | C7orf31 | Chromosome 7 open reading frame 31. (584 aa) |
| | MDM2 | MDM2 proto-oncogene. (689 aa) |
| | SESN2 | Sestrin 2. (482 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | GORAB | Golgin, RAB6 interacting. (395 aa) |
| | SMIM41 | Small integral membrane protein 41. (91 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (452 aa) |
| | A0A4W2D608 | BH4_2 domain-containing protein. (238 aa) |
| | A0A4W2DAZ5 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (272 aa) |
| | PERP | Uncharacterized protein. (204 aa) |
| | FAM76A | Family with sequence similarity 76 member A. (307 aa) |
| | STEAP3 | STEAP3 metalloreductase. (521 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (160 aa) |
| | HPS5 | Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1132 aa) |
| | ZMAT3 | Zinc finger matrin-type 3. (288 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (641 aa) |
| | CHEK1 | Checkpoint kinase 1. (677 aa) |
| | A0A4W2DS38 | Uncharacterized protein. (409 aa) |
| | CCNG2 | Cyclin G2; Belongs to the cyclin family. (344 aa) |
| | A0A4W2DSK5 | TNFR-Cys domain-containing protein. (251 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) |
| | PPM1D | Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa) |
| | A0A4W2DXS4 | RING-type domain-containing protein. (131 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (176 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (398 aa) |
| | GTSE1 | Uncharacterized protein. (480 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (735 aa) |
| | ADGRB1 | Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1457 aa) |
| | CHEK2 | Checkpoint kinase 2. (534 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (427 aa) |
| | A0A4W2EAH1 | Uncharacterized protein. (200 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (428 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (411 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (429 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (161 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | CD82 | Tetraspanin. (272 aa) |
| | CCNB2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa) |
| | A0A4W2EHH7 | Uncharacterized protein. (91 aa) |
| | THBS1 | Thrombospondin 1. (1170 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | TP53I3 | Tumor protein p53 inducible protein 3. (332 aa) |
| | LOC113901903 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | A0A4W2EVF1 | Uncharacterized protein. (308 aa) |
| | A0A4W2F1Y8 | CYCLIN domain-containing protein; Belongs to the cyclin family. (250 aa) |
| | CCNG1 | CYCLIN domain-containing protein; Belongs to the cyclin family. (295 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
