(67 nodes) Longevity regulating pathway - multiple species network (Bos indicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (513 aa)
	A0A4W2BND6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
	FOXO1	Forkhead box O1. (604 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
	A0A4W2C164	Uncharacterized protein; Belongs to the heat shock protein 70 family. (715 aa)
	A0A4W2C5I5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (104 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	FOXO3	Forkhead box O3. (617 aa)
	AKT2	AKT serine/threonine kinase 2. (603 aa)
	FOXA2	Forkhead box A2. (467 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	IRS2	Insulin receptor substrate 2. (1325 aa)
	ADCY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	A0A4W2D126	Uncharacterized protein. (556 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
	CSDE1	Cold shock domain containing E1. (844 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (593 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (299 aa)
	A0A4W2DK00	Uncharacterized protein. (591 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ERAS	ES cell expressed Ras. (185 aa)
	SIRT1	Sirtuin 1. (734 aa)
	CRYAB	Crystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (223 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1335 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	KCNK1	Potassium channel subfamily K member. (336 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
	AKT3	AKT serine/threonine kinase 3. (564 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)
	A0A4W2EG78	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (535 aa)
	FOXA1	Forkhead box A1. (468 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (214 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	A0A4W2EZ36	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (330 aa)
	HSPA6	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (639 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (650 aa)
	AKT1	Non-specific serine/threonine protein kinase. (747 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (565 aa)
	EIF4EBP2	Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	IGF1	Insulin like growth factor 1. (188 aa)
	TIMM8B	Translocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (96 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)

Your Current Organism:

Bos indicus

NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4W2BND6	A0A4W2C164	A0A4W2BND6	A0A4W2C164	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.430
A0A4W2BND6	A0A4W2DK00	A0A4W2BND6	A0A4W2DK00	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.849
A0A4W2BND6	AKT1	A0A4W2BND6	A0A4W2FNQ0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase.	0.554
A0A4W2BND6	AKT2	A0A4W2BND6	A0A4W2CI15	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	AKT serine/threonine kinase 2.	0.560
A0A4W2BND6	AKT3	A0A4W2BND6	A0A4W2EBH0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	AKT serine/threonine kinase 3.	0.441
A0A4W2BND6	FOXA2	A0A4W2BND6	A0A4W2CQ25	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box A2.	0.418
A0A4W2BND6	FOXO1	A0A4W2BND6	A0A4W2BQW9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box O1.	0.541
A0A4W2BND6	FOXO3	A0A4W2BND6	A0A4W2CDX9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Forkhead box O3.	0.433
A0A4W2BND6	IGF1	A0A4W2BND6	A0A4W2I474	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin like growth factor 1.	0.913
A0A4W2BND6	IGF1R	A0A4W2BND6	A0A4W2IC47	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.967
A0A4W2BND6	INSR	A0A4W2BND6	A0A4W2IP97	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.982
A0A4W2BND6	IRS2	A0A4W2BND6	A0A4W2CV17	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor substrate 2.	0.895
A0A4W2BND6	KRAS	A0A4W2BND6	A0A4W2DXR9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	KRAS proto-oncogene, GTPase.	0.441
A0A4W2BND6	MTOR	A0A4W2BND6	A0A4W2CTG3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.499
A0A4W2BND6	PIK3CA	A0A4W2BND6	A0A4W2DQB3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.437
A0A4W2BND6	PRKACA	A0A4W2BND6	A0A4W2GDJ9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.465
A0A4W2BND6	PRKACB	A0A4W2BND6	A0A4W2H3R1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.465
A0A4W2BND6	RPS6KB1	A0A4W2BND6	A0A4W2BS57	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.436
A0A4W2BND6	SIRT1	A0A4W2BND6	A0A4W2DSK9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Sirtuin 1.	0.499
A0A4W2C164	A0A4W2BND6	A0A4W2C164	A0A4W2BND6	Uncharacterized protein; Belongs to the heat shock protein 70 family.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.430

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