STRINGSTRING
LOC113905107 LOC113905107 PROCA1 PROCA1 CACNA1F CACNA1F ITPR1 ITPR1 ADCY9 ADCY9 PLCB3 PLCB3 RAF1 RAF1 PLA2G10 PLA2G10 PLA2G12B PLA2G12B ITPR3 ITPR3 A0A4W2C113 A0A4W2C113 PLA2G6 PLA2G6 CACNA1C CACNA1C PLA2G3 PLA2G3 MYH10 MYH10 PLA2G1B PLA2G1B GNA12 GNA12 KCNU1 KCNU1 EFCAB3 EFCAB3 PLCB1 PLCB1 GUCY1A1 GUCY1A1 AVPR1B AVPR1B RAMP2 RAMP2 PRKCE PRKCE ARHGEF1 ARHGEF1 MRVI1 MRVI1 NPR2 NPR2 MAPK1 MAPK1 AVP AVP EDN3 EDN3 EFCAB13 EFCAB13 AVPR1A AVPR1A PLCB2 PLCB2 GNAS GNAS MYLK2 MYLK2 ADCY2 ADCY2 ROCK2 ROCK2 PLA2G4E PLA2G4E MYLK MYLK A0A4W2CZ07 A0A4W2CZ07 ERF ERF PTRHD1 PTRHD1 MYL9 MYL9 ADCY6 ADCY6 CALM1 CALM1 MAP2K1 MAP2K1 PRKCH PRKCH ADCY4 ADCY4 LOC113879934 LOC113879934 A0A4W2DAY2 A0A4W2DAY2 PLA2G5 PLA2G5 A0A4W2DAZ2 A0A4W2DAZ2 CYP4B1 CYP4B1 A0A4W2DC91 A0A4W2DC91 RAMP1 RAMP1 ITPR2 ITPR2 ARHGEF11 ARHGEF11 ETV3 ETV3 PLA2G2C PLA2G2C LOC113881362 LOC113881362 PLA2G2E PLA2G2E LOC113889930 LOC113889930 ADRA1B ADRA1B CACNA1D CACNA1D PRKCD PRKCD KCNMB3 KCNMB3 PPP1CA PPP1CA A0A4W2DSL7 A0A4W2DSL7 MYLK4 MYLK4 KCNMA1 KCNMA1 A0A4W2DVM0 A0A4W2DVM0 A0A4W2DVM5 A0A4W2DVM5 PPP1R12B PPP1R12B ROCK1 ROCK1 CACNA1S CACNA1S PRKG1 PRKG1 ADCY7 ADCY7 PPP1CC PPP1CC ADCY8 ADCY8 PRKCQ PRKCQ PLA2G4A PLA2G4A A0A4W2E6M6 A0A4W2E6M6 PLCB4 PLCB4 A0A4W2E8Q2 A0A4W2E8Q2 A0A4W2E8R7 A0A4W2E8R7 ADORA2A ADORA2A ARHGEF12 ARHGEF12 ADRA1D ADRA1D ADCY1 ADCY1 RAMP3 RAMP3 PRKCG PRKCG PLA2G4D PLA2G4D LYVE1 LYVE1 A0A4W2EIV4 A0A4W2EIV4 PLA2G4F PLA2G4F ADCY3 ADCY3 PPP1CB PPP1CB ADCY5 ADCY5 BRAF BRAF CALML4 CALML4 PPP1R12A PPP1R12A ESYT2 ESYT2 A0A4W2EXQ9 A0A4W2EXQ9 NPR1 NPR1 AGTR1 AGTR1 ESYT3 ESYT3 ETV3L ETV3L MYH9 MYH9 MYL6 MYL6 MYL6B MYL6B CALCRL CALCRL EDNRA EDNRA GNAQ GNAQ RHOA RHOA MYH14 MYH14 MAP2K2 MAP2K2 GUCY1B1 GUCY1B1 NPPC NPPC GNA11 GNA11 ESYT1 ESYT1 ERFL ERFL PRKACA PRKACA PRKCA PRKCA GNA13 GNA13 NPPA NPPA PPP1R12C PPP1R12C ADRA1A ADRA1A PTGIR PTGIR A0A4W2GYG4 A0A4W2GYG4 PRKACB PRKACB KCNMB4 KCNMB4 EDN2 EDN2 PPP1R14A PPP1R14A MYH11 MYH11 MYLK3 MYLK3 LOC113905106 LOC113905106 LOC113905044 LOC113905044 ADM ADM KCNMB1 KCNMB1 GUCY1A2 GUCY1A2 KCNMB2 KCNMB2 NPPB NPPB PRKCB PRKCB MAPK3 MAPK3 ACTA2 ACTA2 JMJD7 JMJD7 EDN1 EDN1 AGT AGT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC113905107CALCITONIN domain-containing protein. (143 aa)
PROCA1Protein interacting with cyclin A1. (376 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1929 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1117 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PLA2G10Phospholipase A(2). (159 aa)
PLA2G12BPhospholipase A2 group XIIB. (197 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
A0A4W2C113Uncharacterized protein. (173 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
PLA2G1BPhospholipase A(2). (146 aa)
GNA12G protein subunit alpha 12. (382 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1136 aa)
EFCAB3EF-hand calcium binding domain 3. (491 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
RAMP2Receptor activity modifying protein 2. (182 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (968 aa)
MRVI1Murine retrovirus integration site 1 homolog. (911 aa)
NPR2Guanylate cyclase. (1041 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
AVPArginine vasopressin. (199 aa)
EDN3Uncharacterized protein. (271 aa)
EFCAB13EF-hand calcium binding domain 13. (762 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1226 aa)
GNASGNAS complex locus. (1004 aa)
MYLK2Myosin light chain kinase 2. (739 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
PLA2G4EPhospholipase A2. (860 aa)
MYLKMyosin light chain kinase. (2163 aa)
A0A4W2CZ07Phospholipase A2. (821 aa)
ERFETS2 repressor factor. (552 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
MYL9Myosin light chain 9. (172 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (365 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
LOC113879934Phospholipase A(2). (144 aa)
A0A4W2DAY2Phospholipase A(2). (222 aa)
PLA2G5Phospholipase A(2). (160 aa)
A0A4W2DAZ2Phospholipase A(2). (67 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
A0A4W2DC91Uncharacterized protein. (241 aa)
RAMP1Receptor activity modifying protein 1. (148 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1590 aa)
ETV3ETS variant 3. (509 aa)
PLA2G2CPhospholipase A(2). (222 aa)
LOC113881362Phospholipase A(2). (144 aa)
PLA2G2EPhospholipase A(2). (142 aa)
LOC113889930Uncharacterized protein. (906 aa)
ADRA1BAdrenoceptor alpha 1B. (515 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (277 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
A0A4W2DSL7Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (627 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (401 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1276 aa)
A0A4W2DVM0Phospholipase A(2). (144 aa)
A0A4W2DVM5Phospholipase A(2). (144 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (987 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (764 aa)
PLA2G4APhospholipase A2. (749 aa)
A0A4W2E6M6Uncharacterized protein. (73 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1218 aa)
A0A4W2E8Q2Uncharacterized protein. (354 aa)
A0A4W2E8R7CALCITONIN domain-containing protein. (168 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (401 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ADRA1DAdrenoceptor alpha 1D. (567 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
RAMP3Receptor activity modifying protein 3. (150 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (771 aa)
PLA2G4DPhospholipase A2. (808 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (322 aa)
A0A4W2EIV4EF-hand domain-containing protein; Belongs to the calmodulin family. (87 aa)
PLA2G4FPhospholipase A2. (845 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (445 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (805 aa)
CALML4Calmodulin like 4. (153 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1083 aa)
ESYT2Extended synaptotagmin 2. (898 aa)
A0A4W2EXQ9Phospholipase A(2). (139 aa)
NPR1Guanylate cyclase. (1064 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ESYT3Extended synaptotagmin 3. (870 aa)
ETV3LETS variant 3 like. (397 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
MYL6Myosin light chain 6. (151 aa)
MYL6BMyosin light chain 6B. (208 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
GNAQG protein subunit alpha q. (359 aa)
RHOARas homolog family member A. (193 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2040 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
NPPCNatriuretic peptide C. (193 aa)
GNA11G protein subunit alpha 11. (359 aa)
ESYT1Extended synaptotagmin 1. (1116 aa)
ERFLETS repressor factor like. (354 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNA13G protein subunit alpha 13. (377 aa)
NPPANatriuretic peptide A. (188 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (782 aa)
ADRA1AAdrenoceptor alpha 1A. (524 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
EDN2Endothelin 2. (186 aa)
PPP1R14AProtein phosphatase 1 regulatory inhibitor subunit 14A. (147 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
MYLK3Myosin light chain kinase 3. (786 aa)
LOC113905106CALCITONIN domain-containing protein. (123 aa)
LOC113905044Uncharacterized protein. (125 aa)
ADMUncharacterized protein. (456 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (206 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (730 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (268 aa)
NPPBUncharacterized protein. (217 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
JMJD7Jumonji domain containing 7. (316 aa)
EDN1Endothelin 1. (202 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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