STRINGSTRING
MEGF8 MEGF8 ARRB2 ARRB2 SMURF2 SMURF2 A0A4W2E1S4 A0A4W2E1S4 LRP2 LRP2 ATRNL1 ATRNL1 SMURF1 SMURF1 EVC2 EVC2 KIF3A KIF3A GLI2 GLI2 PTCH2 PTCH2 BOC BOC CSNK1A1 CSNK1A1 CSNK1G2 CSNK1G2 EVC EVC ATRN ATRN CSNK1G3 CSNK1G3 PTCH1 PTCH1 DHH DHH TSPAN33 TSPAN33 GSK3B GSK3B LMBR1L LMBR1L GLI3 GLI3 GLI1 GLI1 CUL3 CUL3 IHH IHH LRP4 LRP4 KIF7 KIF7 BTRC BTRC HHIP HHIP CSNK1E CSNK1E SUFU SUFU BCL2 BCL2 LOC113884940 LOC113884940 CDON CDON MGRN1 MGRN1 FBXW11 FBXW11 GRK2 GRK2 LOC113886677 LOC113886677 GRK3 GRK3 ARR3 ARR3 PRKACB PRKACB SMO SMO A0A4W2GSS9 A0A4W2GSS9 CCND2 CCND2 PRKACA PRKACA MOSMO MOSMO CSNK1D CSNK1D LMBR1 LMBR1 CUL1 CUL1 SPOP SPOP GPR161 GPR161 A0A4W2F2V9 A0A4W2F2V9 SPOPL SPOPL KIF27 KIF27 SHH SHH GAS1 GAS1 ARRB1 ARRB1 CSNK1G1 CSNK1G1 CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEGF8Multiple EGF like domains 8. (2789 aa)
ARRB2Arrestin beta 2. (409 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (1071 aa)
A0A4W2E1S4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
LRP2LDL receptor related protein 2. (4647 aa)
ATRNL1Attractin like 1. (1381 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
EVC2EvC ciliary complex subunit 2. (1300 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (892 aa)
GLI2GLI family zinc finger 2. (1573 aa)
PTCH2Patched 2. (1207 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (394 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (414 aa)
EVCEvC ciliary complex subunit 1. (1032 aa)
ATRNAttractin. (1570 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (455 aa)
PTCH1Patched 1. (1453 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (401 aa)
TSPAN33Tetraspanin. (283 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
GLI3GLI family zinc finger 3. (1587 aa)
GLI1GLI family zinc finger 1. (1109 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
LRP4LDL receptor related protein 4. (1905 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1368 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (616 aa)
HHIPHedgehog interacting protein. (701 aa)
CSNK1EProtein kinase domain-containing protein. (490 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
BCL2BCL2 apoptosis regulator. (229 aa)
LOC113884940Uncharacterized protein. (2120 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
MGRN1Mahogunin ring finger 1. (585 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
LOC113886677Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
ARR3Arrestin 3. (389 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (367 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
A0A4W2GSS9Uncharacterized protein. (47 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MOSMOModulator of smoothened. (167 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (447 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (576 aa)
A0A4W2F2V9Uncharacterized protein. (63 aa)
SPOPLSpeckle type BTB/POZ protein like. (413 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1405 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
GAS1Growth arrest specific 1. (578 aa)
ARRB1Arrestin beta 1. (513 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (474 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (428 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: medium (42%) [HD]