STRINGSTRING
LTBP1 LTBP1 THSD4 THSD4 BMPR1A BMPR1A RBX1 RBX1 ZFYVE16 ZFYVE16 NOG NOG MAPK3 MAPK3 A0A4W2I9K4 A0A4W2I9K4 A0A4W2I5C3 A0A4W2I5C3 FST FST PITX3 PITX3 PPP2CA PPP2CA INTS8 INTS8 PPP2CB PPP2CB GDF5 GDF5 TGFB2 TGFB2 LOC113890087 LOC113890087 MYC MYC ID1 ID1 SMAD7 SMAD7 HJV HJV PITX2 PITX2 CDKN2B CDKN2B A0A4W2GSS9 A0A4W2GSS9 GREM1 GREM1 MATN4 MATN4 FBN1 FBN1 BMP2 BMP2 TGIF1 TGIF1 RBL1 RBL1 SMAD5 SMAD5 RHOA RHOA A0A4W2FLF9 A0A4W2FLF9 CUL1 CUL1 SKP1 SKP1 SNAPIN SNAPIN HAMP HAMP ID3 ID3 A0A4W2F2V9 A0A4W2F2V9 ZFYVE9 ZFYVE9 NBL1 NBL1 ADAMTSL4 ADAMTSL4 FSTL3 FSTL3 SMAD3 SMAD3 AMH AMH TGFB3 TGFB3 SP1 SP1 RGMB RGMB ACVR1B ACVR1B FBN3 FBN3 MATN2 MATN2 LDAH LDAH THBS1 THBS1 INHBC INHBC IFNG IFNG BMP4 BMP4 TNF TNF BMPR2 BMPR2 BAMBI BAMBI LOC113906456 LOC113906456 TFDP1 TFDP1 LTBP4 LTBP4 TGFBR2 TGFBR2 SMURF2 SMURF2 FMOD FMOD RGMA RGMA ACVR1C ACVR1C ACVR1 ACVR1 ROCK1 ROCK1 PITX1 PITX1 ANKFN1 ANKFN1 SMAD1 SMAD1 ID4 ID4 SMAD4 SMAD4 SMURF1 SMURF1 INHBB INHBB PKNOX1 PKNOX1 PKNOX2 PKNOX2 BMPR1B BMPR1B CREBBP CREBBP CDKN2A CDKN2A GDF7 GDF7 A0A4W2DDK0 A0A4W2DDK0 BMP7 BMP7 SMAD6 SMAD6 INHBE INHBE DCN DCN CHRD CHRD FBN2 FBN2 NEO1 NEO1 LTBP2 LTBP2 TGIF2 TGIF2 PPP2R1A PPP2R1A ID2 ID2 A0A4W2CWK4 A0A4W2CWK4 GDF6 GDF6 A0A4W2CT92 A0A4W2CT92 INHBA INHBA MAPK1 MAPK1 TGFBR1 TGFBR1 TGFB1 TGFB1 A0A4W2CH33 A0A4W2CH33 A0A4W2CET6 A0A4W2CET6 PPP2R1B PPP2R1B E2F5 E2F5 E2F4 E2F4 A0A4W2C2N7 A0A4W2C2N7 EP300 EP300 BMP5 BMP5 A0A4W2BX47 A0A4W2BX47 NODAL NODAL RPS6KB2 RPS6KB2 A0A4W2BU60 A0A4W2BU60 SMAD2 SMAD2 LTBP3 LTBP3 BMP6 BMP6 RPS6KB1 RPS6KB1 ACVR2B ACVR2B SMAD9 SMAD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTBP1Latent transforming growth factor beta binding protein 1. (1708 aa)
THSD4Thrombospondin type 1 domain containing 4. (1017 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RBX1RING-type domain-containing protein. (128 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1546 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
A0A4W2I9K4Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (58 aa)
A0A4W2I5C3Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (70 aa)
FSTFollistatin. (344 aa)
PITX3Homeobox protein. (302 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
INTS8Integrator complex subunit 8. (995 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
GDF5Growth differentiation factor 5. (499 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC113890087TGF_BETA_2 domain-containing protein. (405 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
PITX2Homeobox protein. (325 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
A0A4W2GSS9Uncharacterized protein. (47 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
MATN4Matrilin 4. (757 aa)
FBN1Fibrillin 1. (2871 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
RHOARas homolog family member A. (193 aa)
A0A4W2FLF9RING-type domain-containing protein. (108 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
HAMPHepcidin antimicrobial peptide. (82 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
A0A4W2F2V9Uncharacterized protein. (63 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1421 aa)
NBL1NBL1, DAN family BMP antagonist. (177 aa)
ADAMTSL4ADAMTS like 4. (1070 aa)
FSTL3Follistatin like 3. (378 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AMHAnti-Mullerian hormone. (560 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
SP1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1209 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (489 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
FBN3Fibrillin 3. (2807 aa)
MATN2Matrilin 2. (1033 aa)
LDAHLipid droplet associated hydrolase. (325 aa)
THBS1Thrombospondin 1. (1170 aa)
INHBCInhibin subunit beta C. (352 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC113906456Left-right determination factor. (367 aa)
TFDP1Transcription factor. (410 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1620 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (1071 aa)
FMODFibromodulin. (376 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (455 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
PITX1Homeobox protein. (314 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (1164 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (164 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
INHBBInhibin subunit beta B. (398 aa)
PKNOX1PBX/knotted 1 homeobox 1. (436 aa)
PKNOX2PBX/knotted 1 homeobox 2. (472 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
CREBBPCREB binding protein. (2435 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
GDF7Growth differentiation factor 7. (411 aa)
A0A4W2DDK0TGF_BETA_2 domain-containing protein. (405 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD6Mothers against decapentaplegic homolog. (529 aa)
INHBEInhibin subunit beta E. (348 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (957 aa)
FBN2Fibrillin 2. (2912 aa)
NEO1Neogenin 1. (1460 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1893 aa)
TGIF2TGFB induced factor homeobox 2. (240 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
A0A4W2CWK4Skp1_POZ domain-containing protein. (65 aa)
GDF6Growth differentiation factor 6. (470 aa)
A0A4W2CT92Left-right determination factor. (367 aa)
INHBAInhibin subunit beta A. (425 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
A0A4W2CH33Metallophos domain-containing protein. (127 aa)
A0A4W2CET6Serine/threonine-protein phosphatase. (259 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (805 aa)
E2F5E2F_TDP domain-containing protein. (313 aa)
E2F4E2F transcription factor 4. (498 aa)
A0A4W2C2N7E2F_CC-MB domain-containing protein. (178 aa)
EP300E1A binding protein p300. (2411 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
A0A4W2BX47Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (79 aa)
NODALNodal growth differentiation factor. (346 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
A0A4W2BU60Uncharacterized protein. (82 aa)
SMAD2Mothers against decapentaplegic homolog. (626 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1341 aa)
BMP6Bone morphogenetic protein 6. (525 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (830 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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