STRINGSTRING
ITGB1 ITGB1 NTN1 NTN1 PIK3R1 PIK3R1 RAC3 RAC3 LIMK2 LIMK2 SSH2 SSH2 WNT5B WNT5B NTN3 NTN3 TRPC6 TRPC6 TRPC3 TRPC3 NTNG2 NTNG2 ABLIM1 ABLIM1 DCC DCC PLXNB2 PLXNB2 SEMA3B SEMA3B UNC5D UNC5D PPP3CB PPP3CB RAF1 RAF1 EPHB4 EPHB4 EPHA7 EPHA7 SRGAP3 SRGAP3 RASA1 RASA1 EPHB3 EPHB3 MAPK3 MAPK3 UNC5A UNC5A PAK1 PAK1 CAMK2B CAMK2B UNC5B UNC5B CFL1 CFL1 SEMA4G SEMA4G SEMA5B SEMA5B SRGAP2 SRGAP2 SEMA7A SEMA7A SSH1 SSH1 HRAS HRAS EPHB2 EPHB2 RRAS RRAS NCK1 NCK1 EPHB1 EPHB1 PTPN11 PTPN11 SMO SMO NFATC3 NFATC3 SEMA3C SEMA3C PLXNA2 PLXNA2 EFNB3 EFNB3 RAC1 RAC1 EPHA3 EPHA3 CAMK2A CAMK2A PRKCA PRKCA ARSI ARSI RHOD RHOD SEMA4B SEMA4B SRMS SRMS NTN4 NTN4 SLIT2 SLIT2 LRRC4C LRRC4C PRKCZ PRKCZ SEMA4D SEMA4D NCK2 NCK2 PIK3R2 PIK3R2 SRC SRC NTNG1 NTNG1 RHOA RHOA EFNA3 EFNA3 EFNA4 EFNA4 EFNA1 EFNA1 GNAI2 GNAI2 PLCG2 PLCG2 WNT5A WNT5A CAMK2D CAMK2D SEMA3A SEMA3A SEMA3E SEMA3E PPP3CA PPP3CA CXCR4 CXCR4 RAC2 RAC2 TRPC1 TRPC1 SEMA4A SEMA4A EPHA2 EPHA2 PIK3R3 PIK3R3 TRPC7 TRPC7 NGEF NGEF A0A4W2EUV9 A0A4W2EUV9 DPYSL2 DPYSL2 SEMA6A SEMA6A SHH SHH EPHB6 EPHB6 EPHA1 EPHA1 GNAI3 GNAI3 CXCL12 CXCL12 EFNA5 EFNA5 FZD3 FZD3 PLCG1 PLCG1 ENAH ENAH PTK6 PTK6 SEMA5A SEMA5A LDAH LDAH FYN FYN PAK6 PAK6 BMPR2 BMPR2 MET MET SSH3 SSH3 EPHA4 EPHA4 SEMA6D SEMA6D ARHGEF12 ARHGEF12 CFL2 CFL2 NRP1 NRP1 SEMA3G SEMA3G PAK4 PAK4 SLIT1 SLIT1 EPHA6 EPHA6 SEMA3D SEMA3D RGMA RGMA UNC5C UNC5C FES FES PIK3CB PIK3CB KRAS KRAS SEMA3F SEMA3F ROCK1 ROCK1 PLXNB1 PLXNB1 PPP3CC PPP3CC SEMA6C SEMA6C CAMK2G CAMK2G LIMK1 LIMK1 ERAS ERAS PIK3CA PIK3CA NRAS NRAS NFATC4 NFATC4 GNAI1 GNAI1 ROBO2 ROBO2 TRPC4 TRPC4 ROBO3 ROBO3 SEMA6B SEMA6B PAK2 PAK2 BMPR1B BMPR1B ABLIM3 ABLIM3 RYK RYK SEMA4C SEMA4C ROBO1 ROBO1 BOC BOC GDF7 GDF7 CDC42 CDC42 PDK1 PDK1 ADAM15 ADAM15 BMP7 BMP7 EPHA5 EPHA5 EPHA10 EPHA10 EPHA8 EPHA8 WNT4 WNT4 CDK5 CDK5 PARD6B PARD6B ABLIM2 ABLIM2 PLXNC1 PLXNC1 PTCH1 PTCH1 A0A4W2D4V5 A0A4W2D4V5 RGS3 RGS3 CSDE1 CSDE1 NEO1 NEO1 DPYSL5 DPYSL5 MYL9 MYL9 PLXNA4 PLXNA4 ROCK2 ROCK2 GSK3B GSK3B RND1 RND1 PAK5 PAK5 ABL1 ABL1 LRRC4 LRRC4 PIK3CD PIK3CD SEMA4F SEMA4F SRGAP1 SRGAP1 EFNB2 EFNB2 MAPK1 MAPK1 NFATC2 NFATC2 PTK2 PTK2 ILK ILK PARD3 PARD3 EFNB1 EFNB1 CCDC125 CCDC125 SLIT3 SLIT3 PARD6A PARD6A MYL12B MYL12B MYL12A MYL12A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NTN1Netrin 1. (713 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAC3Rac family small GTPase 3. (258 aa)
LIMK2LIM domain kinase 2. (628 aa)
SSH2Slingshot protein phosphatase 2. (1429 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
NTN3Netrin 3. (600 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (873 aa)
NTNG2Netrin G2. (611 aa)
ABLIM1Actin binding LIM protein 1. (835 aa)
DCCDCC netrin 1 receptor. (1490 aa)
PLXNB2Plexin B2. (1985 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (753 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
EPHB4EPH receptor B4. (987 aa)
EPHA7EPH receptor A7. (998 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
RASA1RAS p21 protein activator 1. (1044 aa)
EPHB3EPH receptor B3. (997 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
UNC5AUnc-5 netrin receptor A. (902 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (830 aa)
UNC5BUnc-5 netrin receptor B. (934 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SEMA5BSemaphorin 5B. (1113 aa)
SRGAP2Uncharacterized protein. (1084 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
SSH1Slingshot protein phosphatase 1. (988 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EPHB2EPH receptor B2. (986 aa)
RRASRAS related. (218 aa)
NCK1Cytoplasmic protein. (377 aa)
EPHB1EPH receptor B1. (984 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
NFATC3Nuclear factor of activated T cells 3. (1073 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
PLXNA2Plexin A2. (1894 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
RAC1Rac family small GTPase 1. (257 aa)
EPHA3EPH receptor A3. (984 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ARSIArylsulfatase family member I. (574 aa)
RHODRas homolog family member D. (210 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (859 aa)
SRMSTyrosine-protein kinase. (504 aa)
NTN4Netrin 4. (627 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (863 aa)
NCK2Cytoplasmic protein. (376 aa)
PIK3R2Uncharacterized protein. (724 aa)
SRCTyrosine-protein kinase. (559 aa)
NTNG1Netrin G1. (582 aa)
RHOARas homolog family member A. (193 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (325 aa)
GNAI2G protein subunit alpha i2. (436 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (763 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
RAC2Rac family small GTPase 2. (209 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (851 aa)
EPHA2EPH receptor A2. (1007 aa)
PIK3R3Uncharacterized protein. (461 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
NGEFNeuronal guanine nucleotide exchange factor. (667 aa)
A0A4W2EUV9Ephrin RBD domain-containing protein; Belongs to the ephrin family. (449 aa)
DPYSL2Dihydropyrimidinase like 2. (617 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1046 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (464 aa)
EPHB6EPH receptor B6. (1007 aa)
EPHA1EPH receptor A1. (1076 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (204 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (254 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ENAHENAH actin regulator. (823 aa)
PTK6Tyrosine-protein kinase. (450 aa)
SEMA5ASemaphorin 5A. (1084 aa)
LDAHLipid droplet associated hydrolase. (325 aa)
FYNTyrosine-protein kinase. (537 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1384 aa)
SSH3Slingshot protein phosphatase 3. (649 aa)
EPHA4EPH receptor A4. (949 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
EPHA6EPH receptor A6. (1126 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (776 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (455 aa)
UNC5CUnc-5 netrin receptor C. (930 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (793 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1356 aa)
PLXNB1Plexin B1. (2155 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (956 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (596 aa)
LIMK1LIM domain kinase 1. (778 aa)
ERASES cell expressed Ras. (185 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NFATC4Nuclear factor of activated T cells 4. (979 aa)
GNAI1G protein subunit alpha i1. (417 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (984 aa)
ROBO3Roundabout guidance receptor 3. (1385 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (1019 aa)
PAK2Non-specific serine/threonine protein kinase. (600 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (526 aa)
ABLIM3Actin binding LIM protein family member 3. (683 aa)
RYKReceptor like tyrosine kinase. (626 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1119 aa)
ROBO1Roundabout guidance receptor 1. (1650 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1116 aa)
GDF7Growth differentiation factor 7. (411 aa)
CDC42Cell division cycle 42. (191 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
ADAM15ADAM metallopeptidase domain 15. (908 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EPHA5EPH receptor A5. (1031 aa)
EPHA10EPH receptor A10. (1083 aa)
EPHA8EPH receptor A8. (1005 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (585 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PARD6BPar-6 family cell polarity regulator beta. (430 aa)
ABLIM2Actin binding LIM protein family member 2. (701 aa)
PLXNC1Plexin C1. (1597 aa)
PTCH1Patched 1. (1453 aa)
A0A4W2D4V5Uncharacterized protein. (607 aa)
RGS3Regulator of G protein signaling 3. (920 aa)
CSDE1Cold shock domain containing E1. (844 aa)
NEO1Neogenin 1. (1460 aa)
DPYSL5Dihydropyrimidinase like 5. (564 aa)
MYL9Myosin light chain 9. (172 aa)
PLXNA4Plexin A4. (1893 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1469 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (432 aa)
RND1Rho family GTPase 1. (232 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (771 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (342 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1139 aa)
ILKIntegrin linked kinase. (452 aa)
PARD3Par-3 family cell polarity regulator. (1355 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (377 aa)
CCDC125Coiled-coil domain containing 125. (513 aa)
SLIT3Slit guidance ligand 3. (1522 aa)
PARD6APar-6 family cell polarity regulator alpha. (344 aa)
MYL12BMyosin light chain 12B. (171 aa)
MYL12AMyosin light chain 12A. (178 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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