STRINGSTRING
A0A4W2DGD3 A0A4W2DGD3 NFKBIA NFKBIA LOC113896989 LOC113896989 MAPK3 MAPK3 NFKB1 NFKB1 JUN JUN LCK LCK MAP2K7 MAP2K7 TEC TEC TGFB2 TGFB2 IRF9 IRF9 A0A4W2GYG4 A0A4W2GYG4 LOC113897811 LOC113897811 JAK1 JAK1 A0A4W2GMY3 A0A4W2GMY3 TAB2 TAB2 GAB2 GAB2 SRMS SRMS MAPK10 MAPK10 RELA RELA PIK3R2 PIK3R2 FHL2 FHL2 AKT1 AKT1 CHUK CHUK TREM2 TREM2 PLCG2 PLCG2 CAMK4 CAMK4 MAPK9 MAPK9 ACP5 ACP5 PPP3CA PPP3CA CSF1R CSF1R FCGR2B FCGR2B IFNGR2 IFNGR2 PIK3R3 PIK3R3 CALCR CALCR CSF1 CSF1 A0A4W2EML2 A0A4W2EML2 LOC113897812 LOC113897812 PTK6 PTK6 SPI1 SPI1 A0A4W2EKH9 A0A4W2EKH9 RELB RELB IL1B IL1B FYN FYN IFNG IFNG TNF TNF IL1R1 IL1R1 TNFRSF11B TNFRSF11B FOSB FOSB AKT3 AKT3 A0A4W2EAR7 A0A4W2EAR7 TGFBR2 TGFBR2 SPIB SPIB A0A4W2E7C9 A0A4W2E7C9 CREB1 CREB1 A0A4W2E799 A0A4W2E799 A0A4W2E5P9 A0A4W2E5P9 MAP2K6 MAP2K6 A0A4W2E4P7 A0A4W2E4P7 MAP3K14 MAP3K14 STAT1 STAT1 TAB1 TAB1 NCF4 NCF4 CYLD CYLD TNFRSF1A TNFRSF1A PIK3CB PIK3CB MAPK13 MAPK13 PPP3CC PPP3CC NCF1 NCF1 A0A4W2DQB7 A0A4W2DQB7 PIK3CA PIK3CA A0A4W2DPM7 A0A4W2DPM7 SYK SYK JUNB JUNB A0A4W2DLK7 A0A4W2DLK7 FOS FOS LOC113875941 LOC113875941 IFNAR1 IFNAR1 IFNAR2 IFNAR2 TYK2 TYK2 A0A4W2DGC7 A0A4W2DGC7 SQSTM1 SQSTM1 CTSK CTSK FCGR1A FCGR1A MAPK8 MAPK8 MAP2K1 MAP2K1 FOSL2 FOSL2 IFNGR1 IFNGR1 TYROBP TYROBP SIRPA SIRPA A0A4W2CUH3 A0A4W2CUH3 PIK3CD PIK3CD A0A4W2CR26 A0A4W2CR26 MAPK1 MAPK1 NFATC2 NFATC2 STAT2 STAT2 A0A4W2CNA5 A0A4W2CNA5 TGFBR1 TGFBR1 OSCAR OSCAR A0A4W2CM07 A0A4W2CM07 A0A4W2CLY7 A0A4W2CLY7 A0A4W2CLT4 A0A4W2CLT4 BLNK BLNK GRB2 GRB2 A0A4W2CIY8 A0A4W2CIY8 A0A4W2CIV5 A0A4W2CIV5 TGFB1 TGFB1 AKT2 AKT2 A0A4W2CI05 A0A4W2CI05 A0A4W2CHU5 A0A4W2CHU5 IL1A IL1A MAP3K7 MAP3K7 MAPK12 MAPK12 A0A4W2CEF6 A0A4W2CEF6 LCP2 LCP2 FOSL1 FOSL1 NCF2 NCF2 PIK3R1 PIK3R1 CYBA CYBA MITF MITF A0A4W2C2R8 A0A4W2C2R8 NFKB2 NFKB2 MAPK11 MAPK11 A0A4W2BZP2 A0A4W2BZP2 SOCS1 SOCS1 IKBKB IKBKB TNFRSF11A TNFRSF11A RELCH RELCH PPP3CB PPP3CB A0A4W2BUA1 A0A4W2BUA1 A0A4W2BU92 A0A4W2BU92 A0A4W2BU59 A0A4W2BU59 TNFSF11 TNFSF11 TRAF2 TRAF2 A0A4W2BNJ3 A0A4W2BNJ3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A4W2DGD3Uncharacterized protein. (472 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LOC113896989Uncharacterized protein. (186 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (456 aa)
NFKB1Nuclear factor kappa B subunit 1. (974 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
LCKTyrosine-protein kinase. (509 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (658 aa)
TECTyrosine-protein kinase. (655 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IRF9Interferon regulatory factor 9. (439 aa)
A0A4W2GYG4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (379 aa)
LOC113897811Uncharacterized protein. (186 aa)
JAK1Tyrosine-protein kinase. (1110 aa)
A0A4W2GMY3Uncharacterized protein. (246 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
GAB2GRB2 associated binding protein 2. (666 aa)
SRMSTyrosine-protein kinase. (504 aa)
MAPK10Mitogen-activated protein kinase. (425 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PIK3R2Uncharacterized protein. (724 aa)
FHL2Four and a half LIM domains 2. (279 aa)
AKT1Non-specific serine/threonine protein kinase. (747 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
CAMK4Protein kinase domain-containing protein. (750 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (343 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1046 aa)
FCGR2BUncharacterized protein. (316 aa)
IFNGR2Interferon gamma receptor 2. (376 aa)
PIK3R3Uncharacterized protein. (461 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (548 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (575 aa)
A0A4W2EML2Uncharacterized protein. (186 aa)
LOC113897812Uncharacterized protein. (186 aa)
PTK6Tyrosine-protein kinase. (450 aa)
SPI1Spi-1 proto-oncogene. (384 aa)
A0A4W2EKH9Ig-like domain-containing protein. (447 aa)
RELBRELB proto-oncogene, NF-kB subunit. (647 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
FYNTyrosine-protein kinase. (537 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (333 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
AKT3AKT serine/threonine kinase 3. (564 aa)
A0A4W2EAR7Uncharacterized protein. (495 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
SPIBETS domain-containing protein. (259 aa)
A0A4W2E7C9TNF receptor-associated factor. (411 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
A0A4W2E799Uncharacterized protein. (495 aa)
A0A4W2E5P9Uncharacterized protein. (288 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
A0A4W2E4P7Uncharacterized protein. (661 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (953 aa)
STAT1Signal transducer and activator of transcription. (821 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (505 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TNFRSF1ATNF receptor superfamily member 1A. (471 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK13Mitogen-activated protein kinase. (455 aa)
PPP3CCSerine/threonine-protein phosphatase. (531 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
A0A4W2DQB7Ig-like domain-containing protein. (204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
A0A4W2DPM7TPR_REGION domain-containing protein. (325 aa)
SYKTyrosine-protein kinase. (628 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
A0A4W2DLK7Uncharacterized protein. (250 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC113875941Uncharacterized protein. (597 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (561 aa)
IFNAR2Uncharacterized protein. (530 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
A0A4W2DGC7Uncharacterized protein. (186 aa)
SQSTM1Sequestosome 1. (529 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (334 aa)
FCGR1AUncharacterized protein. (349 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
IFNGR1Interferon gamma receptor 1. (500 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (159 aa)
SIRPAUncharacterized protein. (583 aa)
A0A4W2CUH3Uncharacterized protein. (524 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
A0A4W2CR26TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
MAPK1Mitogen-activated protein kinase. (634 aa)
NFATC2Nuclear factor of activated T cells 2. (914 aa)
STAT2Signal transducer and activator of transcription. (857 aa)
A0A4W2CNA5Uncharacterized protein. (589 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
OSCAROsteoclast associated Ig-like receptor. (283 aa)
A0A4W2CM07Ig-like domain-containing protein. (232 aa)
A0A4W2CLY7Uncharacterized protein. (511 aa)
A0A4W2CLT4Uncharacterized protein. (557 aa)
BLNKB cell linker. (480 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
A0A4W2CIY8Uncharacterized protein. (554 aa)
A0A4W2CIV5Ig-like domain-containing protein. (122 aa)
TGFB1Transforming growth factor beta 1. (443 aa)
AKT2AKT serine/threonine kinase 2. (603 aa)
A0A4W2CI05IG domain-containing protein. (220 aa)
A0A4W2CHU5Uncharacterized protein. (341 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
A0A4W2CEF6Integrin beta; Belongs to the integrin beta chain family. (784 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
NCF2Neutrophil cytosolic factor 2. (575 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
A0A4W2C2R8Ig-like domain-containing protein. (215 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
A0A4W2BZP2Uncharacterized protein. (115 aa)
SOCS1Suppressor of cytokine signaling 1. (224 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TNFRSF11ATNF receptor superfamily member 11a. (588 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1220 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
A0A4W2BUA1Uncharacterized protein. (653 aa)
A0A4W2BU92Ig-like domain-containing protein. (208 aa)
A0A4W2BU59Ig-like domain-containing protein. (208 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (316 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
A0A4W2BNJ3Uncharacterized protein. (166 aa)
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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